The aim of this study was to investigate the link between changes in a subject’s serum uric acid levels and the estimated glomerular filtration rate (eGFR) in Japanese women. We used data for 161 Japanese women (49.8 ± 11.7 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. eGFR was negatively correlated with serum uric acid levels (r = -0.402, p < 0.0001) at baseline. Subjects were given advice for dietary and life improvement. At the 1-year follow up, abdominal circumference and systolic blood pressure (SBP) were significantly improved. However, uric acid and eGFR did not change. The changes in eGFR were negatively correlated with uric acid (r = -0.475, p < 0.0001). A decrease in serum uric acid levels was associated with improving eGFR in Japanese women.
 National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Kidney disease outcome quality initiative. American Journal of Kidney Diseases, 39, S1-S266. doi:10.1016/S0272-6386(02)70054-1
 Imai, E., Horio, M., Iseki, K., Yamagata, K., Watanabe, T., Hara, S., Ura, N., Kiyohara, Y., Hirakata, H., Moriyama, T., Ando, Y., Nitta, K., Inaguma, D., Narita, I., Iso, H., Wakai, K., Yasuda, Y., Tsukamoto, Y., Ito, S., Makino, H., Hishida, A. and Matsuo, S. (2007) Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. Clinical and Experimental Nephrology, 11, 156-163. doi:10.1007/s10157-007-0463-x
 Matsuo, S., Imai, E., Horio, M., Yasuda, Y., Tomita, K., Nitta, K., Yamagata, K., Tomino, Y., Yokoyama, H. and Hishida, A., on Behalf of the Collaborators Developing the Japanese Equation for Estimated GFR (2009) Revised equations for estimated GFR from serum creatinine in Japan. American Journal of Kidney Diseases, 53, 982-992. doi:10.1053/j.ajkd.2008.12.034
 Miyatake, N., Shikata, K., Makino, H. and Numata, T. (2010) Relationship between estimated glomerular filtration rate (eGFR) and metabolic syndrome in the Japanese population. Acta Medica Okayama, 64, 203-208.
 Miyatake, N., Shikata, K., Makino, H. and Numata, T. (2010) Decreasing serum uric acid levels might be associated with improving estimated glomerular filtration rate (eGFR) in Japanese men. Health, 3, 498-503.
 Yen, C.J., Chiang, C.K., Ho, L.C., Hsu, S.H., Hung, K.Y., Wu, K.D. and Tsai, T.J. (2009) Hyperuricemia associated with rapid renal function decline in elderly Taiwanese subjects. Journal of the Formosan Medical Association, 108, 921-928. doi:10.1016/S0929-6646(10)60004-6
 Satirapoj, B., Supasyndh, O., Chaiprasert, A., Ruangkanchanasetr, P., Kanjanakul, I., Phulsuksombuti, D., Utainam, D. and Choovihian, P. (2010) Relationship between serum uric acid levels with chronic kidney disease in a Southeaset Asian population. Nephrology (Carlton), 15, 253-258. doi:10.1111/j.1440-1797.2009.01179.x
 See, L.C., Kuo, C.F., Chang, F.H., Shen, Y.M., Ko, Y.S., Chen, Y.M. and Yu, K.H. (2011) Hyperuricemia and metabolic syndrome: Associations with chronic kidney disease. Clinical Rheumatology, 30, 323-330. doi:10.1007/s10067-010-1461-z
 Cain, L., Shankar, A., Ducatman, A.M. and Steenland, K. (2010) The relationship between serum uric acid and chronic kidney disease among Appalachian adults. Nephrology Dialysis Transplantation, 25, 3593-3599. doi:10.1093/ndt/gfq262
 Madero, M., Sarnak, M.J., Wang, X., Greene, T., Beck, G.J., Kusek, J.W., Collins, A.J., Levey, A.S. and Menon, V. (2009) Uric acid and long-term outcomes in CKD. American Journal of Kidney Diseases, 53, 796-803. doi:10.1053/j.ajkd.2008.12.021
 Sturm, G., Kollerits, B., Neyer, U., Ritz, E. and Kronenberg, F. (2008) MMKD Study Group: Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study. Experimental Gerontology, 43, 347-352. doi:10.1016/j.exger.2008.01.006
 Ninomiya, T., Kiyohara, Y., Kubo, M., Yonemoto, K., Tanizaki, Y., Doi, Y., Hirakata, H. and Iida, M. (2006) Metabolic syndrome and CKD in a general Japanese population: The Hisayama Study. American Journal of Kidney Diseases, 48, 383-391. doi:10.1053/j.ajkd.2006.06.003
 Iseki, K., Kohagura, K., Sakime, A., Iseki, C., Kinjo, K., Ikeyama, Y. and Takishita, S. (2007) Changes in the demographics and prevalence of chronic kidney disease in Okinawa, Japan (1993 to 2003). Hypertension Research, 30, 55-62. doi:10.1291/hypres.30.55
 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel Ⅲ). JAMA, 285, 2486-2497.
 Miyatake, N., Kawasaki, Y., Nishikawa, H., Takenami, S. and Numata, T. (2006) Prevalence of metabolic syndrome in Okayama prefecture, Japan. Internal Medicine, 45, 107-108. doi:10.2169/internalmedicine.45.1509
 Endo, M., Kumakura, H., Kanai, H., Araki, Y., Kasama, S., Sumino, H., Ichikawa, S. and Kurabayashi, M. (2010) Prevalence and risk factors for renal artery stenosis and chronic kidney disease in Japanese patients with peripheral arterial disease. Hypertension Research, 33, 911-915. doi:10.1038/hr.2010.93
 Iso, S., Naritomi, H., Ogihara, T., Shimada, K., Shimamoto, K., Tanaka, H. and Yoshiike, N. (2012) Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan. Hypertension Research, 35, 867-873. doi:10.1038/hr.2012.59