Back
 NJGC  Vol.3 No.2 , April 2013
Chronology of Bioactive Glass Development and Clinical Applications
Abstract: The key research and development steps for bioactive glass (45S5 Bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with living bone was a vital part of the early development of this class of biomaterials. A key later discovery was enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the bioactive glass particulates that leads to up-regulation and activation of seven families of genes, a process called osteostimulation.
Cite this paper: L. Hench, "Chronology of Bioactive Glass Development and Clinical Applications," New Journal of Glass and Ceramics, Vol. 3 No. 2, 2013, pp. 67-73. doi: 10.4236/njgc.2013.32011.
References

[1]   L. L. Hench, R. J. Splinter, W. C. Allen and T. K. Greenlee Jr., “Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials,” Journal of Biomedical Materials Research, Vol. 2, No. 1, 1971, pp. 117-141. doi:10.1002/jbm.820050611

[2]   C. A. Beckham, T. K. Greenlee Jr. and A. R. Crebo Jr., “Bone Formation at a Ceramic Implant Interface,” Calcified Tissue Research, Vol. 8, No. 1, 1971, pp. 165-171. doi:10.1007/BF02010133

[3]   T. K. Greenlee Jr., C. A. Beckham, A. R. Crebo and J. C. Malmborg, “Glass Ceramic Bone Implants,” Journal of Biomedical Materials Research, Vol. 6, No. 3, 1972, pp. 235-244. doi:10.1002/jbm.820060312

[4]   U. Gross and V. Strunz, “The Interface of Various Glasses and Glass-Ceramics with a Bony Implantation Bed,” Journal of Biomedical Materials Research, Vol. 19, No. 3, 1985, pp. 251-271. doi:10.1002/jbm.820190308

[5]   T. Kokubo, S. Ito, S. Sakka and T. Yamamuro, “Formation of a High-Strength Bioactive Glass-Ceramic in the System MgO-CaO-SiO2-P2O5,” Journal of Materials Science, Vol. 21, No. 2, 1986, pp. 536-540. doi:10.1007/BF01145520

[6]   T. Yamamuro, L. L. Hench and J. Wilson, “Handbook on Bioactive Ceramics: Bioactive Glasses and Glass-Ceramics,” Vol. 1. CRC Press, Boca Raton, 1990.

[7]   L. L. Hench and H. A. Paschall, “Direct Chemical Bonding of Bioactive Glass-Ceramic Materials and Bone,” Journal of Biomedical Materials Researc, Vol. 7, No. 4, 1973, pp. 25-42. doi:10.1002/jbm.820070304

[8]   L. L. Hench and H. A. Paschall, “Histo-Chemical Responses at a Biomaterials Interface,” Journal of Biomedical Materials Researc, No. 5, 1974, pp. 49-64.

[9]   G. Piotrowski, L. L. Hench, W. C. Allen and G. J. Miller, “Mechanical Studies of the Bone-Bioglass Interfacial Bond,” Journal of Biomedical Materials Researc, Vol. 9, No. 4, 1975, pp. 47-61. doi:10.1002/jbm.820090408

[10]   L. L. Hench, H. A. Paschall, W. C. Allen and G. Piotrowski, “Interfacial Behavior of Ceramics Implants,” National Bureau of Standards Special Publication, Vol. 415, 1975, pp. 19-35.

[11]   P. Griss, D. C. Greenspan, G. Heimke, B. Krempien, R. Buchinger, L. L. Hench and G. Jentschura, “Evaluation of a Bioglass Coated Al2O3 Total Hip Prosthesis in Sheep,” Journal of Biomedical Materials Research, Vol. 10, No. 4, 1976, pp. 511-518. doi:10.1002/jbm.820100406

[12]   A. E. Clark, L. L. Hench and H. A. Paschall “The Influence of Surface Chemistry on Implant Interface Histology: A Theoretical Basis for Implant Materials Selection,” Journal of Biomedical Materials Research, Vol. 10, No. 2, 1976, pp. 161-174. doi:10.1002/jbm.820100202

[13]   J. J. Hren, P. F. Johnson, S. R. Bates and L. L. Hench, “STEM/EDX Analysis of Bone-Bioglass Interface,” Electron Microscopy Society of America, 1976, pp. 290-291.

[14]   H. Oonishi, L. L. Hench, J. Wilson, F. Sugihara, E. Tsuji, M. Matsuwura, S. Kin, T. Yamamoto and S. Mizokawa, “Quantitative Comparison of Bone Growth Behaviour in Granules in Bioglass®, A-W GlassCeramic, and Hydroxyapatite,” Journal of Biomedical Materials Research, Vol. 51, No. 1, 2000, pp. 37-46. doi:10.1002/(SICI)1097-4636(200007)51:1<37::AID-JBM6>3.0.CO;2-T

[15]   L. L. Hench and A. E. Clark, “Adhesion to Bone,” In: D. F. Williams and G. D. Winter, Eds., Biocompatibility of Orthopaedic Implants, Vol. 2, Chapter 6, CRC Press, Boca Raton, 1982, pp. 85-105.

[16]   J. Wilson, G. H. Pigott, F. J. Schoen and L. L. Hench, “Toxicology and Biocompatibility of Bioglass,” Journal of Biomedical Materials Research, Vol. 15, No. 6, 1981, p. 805. doi:10.1002/jbm.820150605

[17]   L. L. Hench, June W. Hench and D. C. Greenspan, “Bioglass: A Short History and Bibliography,” Journal of the Australian Ceramic Society, Vol. 40, No. 1, 2004, pp. 1-42.

[18]   L. L. Hench, “Bioceramics: From Concept to Clinic,” Journal of the American Ceramic Society, Vol. 74, No. 7, 1991, pp. 1487-1510. doi:10.1111/j.1151-2916.1991.tb07132.x

[19]   L. L. Hench, “Bioceramics,” Journal of the American Ceramic Society, Vol. 81, No. 7, 1998, pp. 1705-1728. doi:10.1111/j.1151-2916.1998.tb02540.x

[20]   L. L. Hench, “Characterization of Glass Corrosion and Durability,” Journal of Non-Crystalline Solids, Vol. 19, 1975, pp. 27-39. doi:10.1016/0022-3093(75)90067-8

[21]   A. E. Clark Jr., C. G. Pantano Jr. and L. L. Hench, “Auger Spectroscopic Analysis of Bioglass Corrosion Films,” Journal of the American Ceramic Society, Vol. 59, No. 1-2, 1976, pp. 37-39. doi:10.1111/j.1151-2916.1976.tb09382.x

[22]   C. Y. Kim, A. E. Clark and L. L. Hench, “Early Stages of Calcium-Phosphate Layer Formation in Bioglass,” Journal of Non-Crystalline Solids, Vol. 113, No. 2-3, 1989, pp. 195-202. doi:10.1016/0022-3093(89)90011-2

[23]   L. L. Hench and D. E. Clark, “Physical Chemistry of Glass Surfaces,” Journal of Non-Crystalline Solids, Vol. 28, No. 1, 1978, pp. 83-105. doi:10.1016/0022-3093(78)90077-7

[24]   I. D. Xynos, M. V. J. Hukkanen, J. J. Batten, I. D. Buttery, L. L. Hench and J. M. Polak, “Bioglass® 45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation in Vitro: Implications and Applications for Bone Tissue Engineering,” Calcified Tissue International, Vol. 67, No. 4, 2000, pp. 321-329. doi:10.1007/s002230001134

[25]   L. L. Hench, J. M. Polak, I. D. Xynos and L. D. K. Buttery, “Bioactive Materials to Control Cell Cycle,” Material Research Innovations, Vol. 3, No. 6, 2000, pp. 313-323. doi:10.1007/s100190000055

[26]   I. D. Xynos, A. J. Edgar, L. D. Buttery, L. L. Hench and J. M. Polak. “Ionic Dissolution Products of Bioactive Glass Increase Proliferation of Human Osteoblasts and Induce Insulin-Like Growth Factor II mRNA Expression and Protein Synthesis,” Biochemical and Biophysical Research Communications, Vol. 276, No. 2, 2000, pp. 461-465. doi:10.1006/bbrc.2000.3503

[27]   I. D. Xynos, A. J. Edgar, L. D. K. Buttery, L. L. Hench and J. M. Polak, “Gene Expression Profiling of Human Osteoblasts Following Treatment with the Ionic Dissolution Products of Bioglass® 45S5 Dissolution,” Journal of Biomedical Materials Research, Vol. 55, No. 2, 2001, pp. 151-157. doi:10.1002/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D

[28]   L. L. Hench, I. D. Xynos, A. J. Edgar, L. D. K. Buttery, J. M. Polak, J. P. Zhong, X. Y. Liu and J. Chang, “Gene Activating Glasses,” Journal of Inorganic Materials, Vol. 17, 2002, pp. 897-909.

[29]   L. L. Hench, “Glass and Genes: The 2001 W. E. S. Turner Memorial Lecture,” Glass Technology, Vol. 44, 2003, pp. 1-10.

[30]   L. L. Hench, “Bioactive Glasses: Gene Activation, Chapter 4,” In: L. L. Hench, Ed., An Introduction to Bioceramcs, 2nd Edition, Imperial College Press, London, 2013, pp. 63-68.

[31]   H. R. Stanley, L. L. Hench, R. Going, C. Bennett, S. J. Chellemi, C. King, N. Ingersoll, E. Ethridge and K. Kreutziger, “The Implantation of Natural Tooth Form Bioglasses in Baboons,” Oral Surgery, Oral Medicine, Oral Pathology, Vol. 45, No. 5, 1976, pp. 339-356. doi:10.1016/0030-4220(76)90168-7

[32]   H. R. Stanley, et al., “Implantation of Natural Tooth Form Bioglasses in Baboon,” The International Journal of Oral Implantology, Vol. 1, 1976, p. 2.

[33]   M. S. Karlan, L. L. Hench, M. Madden and M. Ogino, “A Bone-Bonding Bioactive Material Implant in the Head and Neck: Bioglass,” Surgical Forum, Vol. 39, 1979, pp. 575-577.

[34]   H. R. Stanley, L. L. Hench, C. G. Bennett Jr., S. J. Chellemi, C. J. King III, R. E. Going, N. J. Ingersoll, E. C. Ethridge, K. L. Kreutziger, L. Loeb and A. E. Clark, “The Implantation of Natural Tooth Form Bioglass® in Baboons—Long Term Results,” The International Journal of Oral Implantology, Vol. 2, No. 2, 1981, pp. 26-36.

[35]   G. E. Merwin, J. S. Atkins, J. Wilson and L. L. Hench, “Comparison of Ossicular Replacement Materials in a Mouse Ear Model,” Otolaryngology. Head and Neck Surgery, Vol. 90, No. 4, 1982, pp. 461-469.

[36]   J. Wilson, J. S. Atkins, G. E. Merwin and L. L. Hench. “Histopathological Evaluation of Interaction between Tympanic Membrane and Implant Materials,” Transactions of the Society for Biomaterials, Vol. 8, 1985, p. 195.

[37]   G. Merwin, L. Rogers, J. Wilson and R. Martin, “Facial Bone Augmentation Using Bioglass® in Dogs,” Archives of Otolaryngology-Head and Neck Surgery, Vol. 112, No. 3, 1986, pp. 280-284.

[38]   G. E. Merwin, “Bioglass® Middle Ear Prosthesis: Preliminary Report,” The Annals of Otology, Rhinology, and Laryngology, Vol. 5, No. 1, Part 1, 1986, pp. 78-82.

[39]   J. Wilson, S. Low, A. Fetner and L. L. Hench, “Bioactive Materials for Periodontal Treatment: A Comparative Study,” In: A. Pizzoferrato, P. G. Marchetti, A. Ravaglioli and A. J. C. Lee, Eds., Biomaterials and Clinical Applications, Elsevier Science Publishers, Amsterdam, 1987, pp. 223-228.

[40]   M. B. Hall, H. R. Stanley, C. King, F. Colaizzi, D. Spilman and L. L. Hench, “Early Clinical Trials of 45S5 Bioglass® for Endosseous Ridge Maintenance with a New Endosseous Implant Material,” The Journal of Prosthetic Dentistry, Vol. 58, No. 5, 1987, pp. 607-613. doi:10.1016/0022-3913(87)90393-3

[41]   H. R. Stanley, M. B. Hall, F. Colaizzi and A. E. Clark, “Residual Alveolar Ridge Maintenance with a New Endosseous Implant Material,” Journal of Prosthetic Dentistry, Vol. 58, No. 5, 1987, pp. 607-613.

[42]   J. Wilson and G. E. Merwin, “Biomaterials for Facial Bone Augmentation: Comparative Studies,” Journal of Biomedical Materials Research, Vol. 22, Suppl. A2, 1988, pp. 159-177. doi:10.1002/jbm.820221308

[43]   J. Wilson and S. B. Low, “Bioactive Ceramics for Periodontal Treatment: Comparative Studies in the Patus Monkey,” Journal of Applied Biomaterials, Vol. 3, No. 2, 1992, pp. 123-169. doi:10.1002/jab.770030208

[44]   L. L. Hench, Ed., “An Introduction to Bioceramics,” Chapters 6-12 & 31, 2nd Edition, Imperial College Press, London, 2013.

[45]   L. L. Hench and J. K. West, “The Sol-Gel Process,” Chemical Reviews, Vol. 90, No. 1, 1990, pp. 33-72. doi:10.1021/cr00099a003

[46]   R. Li, A. E. Clark, and L. L. Hench, “An Investigation of Bioactive Glass Powders by Sol-Gel Processing,” Journal of Applied Biomaterials, Vol. 2, No. 4, 1991, pp. 231-239. doi:10.1002/jab.770020403

[47]   P. Sepulveda, J. R. Jones, L. L. Hench, “Synthesis of Sol-Gel Derived Bioactive Foams,” Key Engineering Materials, Vol. 218-220, 2002, pp. 287-290.

[48]   P. Sepulveda, J. R. Jones and L. L. Hench, “Bioactive Sol-Gel Foams for Tissue Repair,” Journal of Biomedical Materials Research, Vol. 59, No. 2, 2002, pp. 340-348. doi:10.1002/jbm.1250

[49]   P. Sepulveda, J. R. Jones, L. L. Hench, “The Effect of Temperature on the Processing and Properties of Macroporous Bioactive Glass Foams,” Key Engineering Materials, Vol. 218-220, 2002, pp. 299-302.

[50]   P. Sepulveda, J. R. Jones, L. L. Hench, “In Vitro Dissolution of Melt-Derived 45S5 and Sol-Gel Derived 58S Bioactive Glasses,” Journal of Biomedical Materials Research, Vol. 61, No. 2, 2002, pp. 301-311. doi:10.1002/jbm.10207

[51]   P. Sepulveda, J. R. Jones and L. L. Hench, “Bioactive Materials for Tissue Engineering Scaffolds,” In: J. M. Polak, L. L. Hench and P. Kemp, Eds., Future Strategies for Tissue and Organ Replacement, Imperial College Press, London, 2002, pp. 3-24.

[52]   R. F. S. Lenza, J. R. Jones, W. L. Vasconcelos and L. L. Hench, “Surface Modified 3D Scaffolds for Tissue Engineering,” Journal Materials Science, Materials in Medicine, Vol. 13, No. 9, 2002, pp. 837-842. doi:10.1023/A:1016592127407

[53]   J. R. Jones, “Review of Bioactive Glass: From Hench to Hybrids,” Acta Biomateriala, Vol. 9, No. 1, 2012, pp. 4457-4486.

[54]   A. G. Stamboulis, A. R. Boccaccini and L. L. Hench, “Novel Biodegradable Polymer/Bioactive Glass Composites for Tissue Engineering Applications,” Advanced Engineering Materials, Vol. 4, No. 3, 2002, pp. 105-109. doi:10.1002/1527-2648(200203)4:3<105::AID-ADEM105>3.0.CO;2-L

[55]   A. R. Boccaccini, J. A. Roether, L. L. Hench, V. Maquet and R. Jérôme, “A Composites Approach to Tissue Engineering,” Ceramic Engineering and Science Proceedings, Vol. 23, No. 4, 2002, pp. 805-816. doi:10.1002/9780470294758.ch90

[56]   J. A. Roether, J. Gough, A. R. Boccaccini, V. Maquet and L. L. Hench, “Novel Bioresorbable and Bioactive Composites Based on Bioactive Glass and Polyactide Foams for Bone Tissue Engineering,” Journal of Materials Science: Materials in Medicine, Vol. 13, No. 12, 2002, pp. 1207-1214. doi:10.1023/A:1021166726914

[57]   P. Sepulveda, J. R. Jones and L. L. Hench, “Bioactive Sol-Gel Foams for Tissue Repair,” Journal of Biomedical Materials Research, Vol. 59, No. 2, 2002, pp. 340-348. doi:10.1002/jbm.1250

[58]   Julian R. Jones, “Review of Bioactive Glass: From Hench to Hybrids,” Acta Biomaterialia, Vol. 9, No. 1, 2013, pp. 4457-4486.

 
 
Top