IJCM  Vol.4 No.4 , April 2013
Melanoma of the Oral Cavity: About Two Cases and Review of Literature
ABSTRACT

Mucosal malignant melanoma of the oral cavity is an extremely rare condition. It has a poor prognosis. Here we report two typical cases of malignant melanoma. In the first case, 64 years old man developed an exophytic tumor in the hard palate. Head and neck and chest computerized tomography scan showed a large aggressive tumor of the hard palate. The patient also had multiple lung metastases and a cervical lymph node. The second case is a 73 years old woman presenting a burgeoning mass on the right palate. Facial CT reveals a malignant tumor lateralized in the right palate with ipsilateral metastatic lymph nodes. Histological with immunohistochemical studies assigned both cases to a malignant melanoma. Due to the rarity of oral malignant melanomas, case reports are a necessary source of information.


Cite this paper
F. Elomrani, H. Mouzount, I. Ouziane, R. Khmamouch, S. lkhoyali, A. Boukir, M. ElKabous, S. Boutayeb, H. Mrabti, B. Elkhannoussi and H. Errihani, "Melanoma of the Oral Cavity: About Two Cases and Review of Literature," International Journal of Clinical Medicine, Vol. 4 No. 4, 2013, pp. 191-194. doi: 10.4236/ijcm.2013.44033.
References
[1]   D. Jackson and H. E. Simpson, “Primary Malignant Melanoma of the Oral Cavity,” Oral Surgery, Oral Medicine, Oral Pathology, Vol. 39, No. 6, 1975, pp. 553-559. doi:10.1016/0030-4220(75)90194-2

[2]   N. J. D’Silva, Z. Kurago, P. J. Polverini, C. T. Hanks and A. F. Paulino, “Malignant Melanoma of the Oral Mucosa in a 17-Year-Old Adolescent Girl,” Archives of Pathology & Laboratory Medicine, Vol. 126, No. 9, 2002, pp. 1110-1113.

[3]   R. I. van der Waal, G. B. Snow, A. B. Karim and I. Van der Waal, “Primary Malignant Melanoma of the Oral Cavity: A Review of Eight Cases,” British Dental Journal, Vol. 176, No. 5, 1994, pp. 185-188. doi:10.1038/sj.bdj.4808406

[4]   M. Hashemipour, “Malignant Melanoma of the Oral Cavity,” Journal of Dentistry, Vol. 4, No. 1, 2007, pp. 44-51.

[5]   B. Colllins, E. Leon Barnes Jr. and J. Abernethy, “Oral Malignant Melanoma,” Journal of Clinical Oncology, Vol. 55, 2005, pp. 74-108.

[6]   Bork, Hoede, Korting, Burgdorf and Young, “Diseases of the Oral Mucosa and the Lips,” W. B. Saunders, Philadelphia, 1996, pp. 336-340.

[7]   R. Rajendran and B. Sivapada Sundaram, “Benign and Malignant Tumors of the Oral Cavity,” In: Shafer, Hine and Lavy, Eds., Shafer’s Text Book of Oral Pathology, Elsevier India, 2009, pp. 120-127.

[8]   M. Singh, J. Lin, T. L. Hocker and H. Tsao, “Genetics of Melanoma Tumerogenesis,” British Journal of Dermatology, Vol. 158, No. 1, 2008, pp. 15-21. doi:10.1111/j.1365-2133.2007.08316.x

[9]   A. D. Rapidis, C. Apostolidis, G. Vilos and S. Valsamis, “Primary Malignant Melanoma of the Oral Mucosa,” Journal of Oral and Maxillofacial Surgery, Vol. 61, No. 10, 2003, pp. 1132-1139. doi:10.1016/S0278-2391(03)00670-0

[10]   N. E. Steidler, P. C. Reade and B. G. Radden, “Malignant Melanoma of the Oral Mucosa,” Journal of Oral and Maxillofacial Surgery, Vol. 42, No. 5, 1984, pp. 333-336. doi:10.1016/0278-2391(84)90116-2

[11]   S. R. Prabhu, D. F. Wilson and D. K. Daftary, “Oral Diseases in the Tropics,” Oxford University Press, New York, 1992, pp. 460-461.

[12]   D. Jackson and H. E. Simpson, “Primary Malignant Melanoma of the Oral Cavity,” Oral Surgery, Oral Medicine, Oral Pathology, Vol. 39, 1975, pp. 553-559. doi:10.1016/0030-4220(75)90194-2

[13]   N. K. Wood and P. W. Goaz, “Differential Diagnosis of Oral and Maxillofacial Lesions,” 5th Edition, Maryland Heights, 1997, pp. 67-68, 190.

[14]   B. F. Barker, W. M. Carpenter, T. E. Daniels, M. A. Kahn, A. S. Leider, F. Lozada-Nur, et al., “Oral Mucasal Melanomas: The WESTOP Banff Workshop Preceedings: Western Society of Teachers of Oral Pathology,” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, Vol. 83, No. 6, 1977, pp. 672-679. doi:10.1016/S1079-2104(97)90318-8

[15]   M. S. Hashemi Pour, “Malignant Melanoma of the Oral Cavity: A Review of Literature,” Indian Journal of Dental Research, Vol. 19, No. 1, 2008, pp. 47-51. doi:10.4103/0970-9290.38932

[16]   S. J. Ohsie and G. Peter, “Immunohistochemical Characteristics of Melanoma,” Journal of Cutaneous Pathology, Vol. 35, No. 5, 2008, pp. 433-444. doi:10.1111/j.1600-0560.2007.00891.x

[17]   B. Collins II, “Oral Malignant Melanoma,” Emedecine Medscape, 2011.

[18]   P. B. Chapman, A. Hauschild, C. Robert, et al., “Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation,” The New England Journal of Medicine, Vol. 364, No. 26, 2011, pp. 2507-2516. doi:10.1056/NEJMoa1103782

[19]   E. Vairaktaris, I. Iatrou, V. Ragos, K. Petraki and C. Martis, “Primary Melanoma of the Oral Cavity,” Helleniko Periodiko gia Stomatike & Gnathoprosopike Cheirourgike, Vol. 4, 1989, pp. 31-36.

 
 
Top