A new production method of no-carrier-added 64Cu was tested using a new target prepared by electroplating of Ni on a silver layer (thickness 35 μm) previously electroplated on a pure copper target support. This method meets cost effective production and quality of the produced 64Cu criteria.The quality of the electroplated layers has been tested under the bombardment by more than 200 μA of proton beam using water cooled target system. A separation and purification setup was elaborated to produce high quantity and high specific activity of 64CuCl2 suitable for labeling different ligands in order to be used in therapy and diagnosis. A semi-automated target dissolution and separation system has been developed and achieved for 64Cu production. The separation chemistry is based on a chromatographic column system.
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