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 IJOC  Vol.3 No.1 A , April 2013
Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives
Abstract: A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.
Cite this paper: D. Shao, Y. Yang, F. Xue, X. Luo, R. Wubulikasimu, Y. Li, R. Gao and W. Ye, "Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives," International Journal of Organic Chemistry, Vol. 3 No. 1, 2013, pp. 41-46. doi: 10.4236/ijoc.2013.31A005.
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