IJOC  Vol.3 No.1 A , April 2013
Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives
ABSTRACT

A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.


Cite this paper
D. Shao, Y. Yang, F. Xue, X. Luo, R. Wubulikasimu, Y. Li, R. Gao and W. Ye, "Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives," International Journal of Organic Chemistry, Vol. 3 No. 1, 2013, pp. 41-46. doi: 10.4236/ijoc.2013.31A005.
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