epidemiological studies have shown an inverse association between the
consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular
diseases. The purpose of the study was to emphasize the effects of the
association between the renin inhibitor and the polyphenolic extract on biochemical
parameters and systolic and diastolic blood pressure. The polyphenols are
extracted from isolated and purified vegetable material represented by the
mature fruit of the Aronia melanocarpa.
The experiment was performed on the arterial hypertension model. In the
arterial hypertensive model the cardioprotective effects of the polyphenolic
extract from Aronia melanocarpa are represented by the antioxidant,
hypocolesterolemiant intervention. Polyphenolic extract from Aronia melanocarpa reduce systolic and
diastolic arterial tension values in rats with drug-induced hypertension, a phenomenon more pronounced when
polyphenols are associated with Aliskiren (renin inhibitor). The combination
between the Aliskiren and polyphenolic extract produce superior hypolipidemic
and antioxidant effects than in the case of separate administration within
experimental arterial hypertension induced in the murine model.
Cite this paper
Ciocoiu, M. , Badescu, M. , Badulescu, O. , Tutunaru, D. and Badescu, L. (2013) Polyphenolic extract association with renin inhibitors in experimental arterial hypertension. Journal of Biomedical Science and Engineering, 6, 493-497. doi: 10.4236/jbise.2013.64062.
 Oszmianski, J. and Wojdylo, A. (2005) Aronia melanocarpa phenolics and their antioxidant activity. European Food Research and Technology, 1, 1-5.
 Pascual-Teresa, S. and Sanchez-Ballesta, M.T. (2008) Anthocyanins: From plant to health. Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe, 7, 281-299.
 Mennen, L.I., Sapinho, D. and De Bree, A. (2004) Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women. The Journal of Nutrition, 134, 923-926.
 Bell, D.R. and Gochenaur, K. (2006) Direct vasoactive and vasoprotective properties of anthocyanin—Rich extracts. Journal of Applied Physiology, 100, 1164-1170.
 Yao, L.H., Jiang, Y.M., Shi, J., Tomas-Barberan, F.A., Datta, N. and Singanusong, R. (2004) Flavonoids in food and their health benefits. Plant Foods for Human Nutrition, 59, 113-122.
 Lee-Hilz, Y.Y., Boerboom, A.M., Westphal, A.H., Berkel, W.J., Aarts, J.M. and Rietjens I.M. (2006) Pro-oxidant activity of flavonoids induces EpRE mediated gene expression. Chemical Research in Toxicology, 19, 1499-1505.
 Rahman, I., Biswas, S.K. and Kirkham, P.A. (2006) Regulation of inflammation and redox signaling by dietary polyphenols. Biochemical Pharmacology, 72, 1439-1452.
 Hernandez-Montes, E., Pollard, S.E., Vauzour, D., Jofre- Montseny, L., Rota, C. and Rimbach, G. (2006) Activation of glutathione peroxidase via Nrf1 mediates genistein’s protection against oxidative endothelial cell injury. Biochemical and Biophysical Research Communications, 346, 851-859. doi:10.1016/j.bbrc.2006.05.197
 Masella, R., Di Benedetto, R., Vari, R., Filesi, C. and Giovannini, C. (2005) Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes. The Journal of Nutritional Biochemistry, 16, 577-586.
 Kokotkiewicz, A., Jaremicz, Z. and Luczkiewicz, M. (2010) Aronia plants: A review of traditional use, biological activities, and perspectives for modern medicine. Journal of Medicinal Food, 13, 255-269. doi:10.1089/jmf.2009.0062
 Naruszewicz, M., Laniewska, I., Millo, B. and Dluzniewski, M. (2007) Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction. Atherosclerosis, 194, e179-e184.