purpose of this study was to evaluate the association
among serum organochlorine pesticide residues, glutathione S-transferase M1
genetic polymorphism and female breast cancer. Methods: A 1:1 matched
case-control study of 140 newly diagnosed breast cancer patients and 140
non-cancer female patients who consulted the five largest hospitals in the Tangshan
city from September 2006 to October
2007. Results:The result showed higher risk of breast cancer among
subjects with higher levels of serum DDT and HCH residue, the OR was 3.18(95%CI, 1.11 - 9.07)
and 5.02(95%CI, 1.64 - 16.56).The value of ORe associated with single environmental factor DDT high
residues,and ORgassociated with single GSTM1 deletion genotype were respectively 3.86 (1.20 - 12.47)
and 1.34 (0.36 - 5.08). The OReg associated with combined action of two factors was 5.59(1.63 - 18.90),
and the value of interaction parameters(γ) equaled 1.24. The value of OReassociated with single
environmental factor HCH higher residue and ORgassociated with single GSTM1 deletion genotype were respectively 2.73(0.84 - 8.87)
and 1.48(0.49 - 4.60). The value of OReg associated with combined action of two factors was 3.87(1.18 - 12.68),
and γ equaled 1.38. Conclusion:The
results indicated that breast cancer occurrence was the combined result of
environmental and genetic factors. The concurrent action of GSTM1 deletion
genotype and DDT/HCH enhanced the risk of breast cancer.
Cite this paper
Li, J. , Jiang, S. , Chang, Y. , Guo, Z. , Yao, S. , Yuan, J. and Li, G. (2013) Association among Serum Organochlorine Pesticide Residues, Glutathione S-Transferase M1 Genetic Polymorphism and Female Breast Cancer. Advances in Breast Cancer Research, 2, 19-23. doi: 10.4236/abcr.2013.22005.
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