OJBIPHY  Vol.3 No.2 , April 2013
Poly(N-Vinyl Pyrrolidone-b-Dimethylsiloxane) Electrospun Nanofibers: Preparation, Characterization and Biological Response
ABSTRACT
Here we report electrospinning of Poly(dimethylsiloxane-b-vinyl pyrrolidone) (PDMS-b-PVP) based fibrous scaffold materials. The morphology, thermal properties, surface composition, hydrophilicity and fibers formation with different PDMS and PVP chain lengths were determined by using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray photoelectron microscopy (XPS) and X-ray diffraction (RXD) water vapor uptake and water contact angle (WCA). The electrospinning parameters were controlled as well as fiber deposition area. The influence of polymer solution concentration on the morphology of electrospun fibers was also investigated. We checked out the applicability of the electrospun fibers for tissue engineering by the investigation of their capability to support fibroblast cell adhesion, cell growth and proliferation.



Cite this paper
I. Keranov, M. Michel, A. Kostadinova, V. Toniazzo, D. Ruch and T. Vladkova, "Poly(N-Vinyl Pyrrolidone-b-Dimethylsiloxane) Electrospun Nanofibers: Preparation, Characterization and Biological Response," Open Journal of Biophysics, Vol. 3 No. 2, 2013, pp. 148-157. doi: 10.4236/ojbiphy.2013.32018.
References
[1]   [1] S. Agarwal, J. H. Wendorff and A. Greiner, “Use of Electrospinning Technique for Biomedical Applications,” Polymer, Vol. 49, No. 26, 2008, pp. 5603-5621. doi:10.1016/j.polymer.2008.09.014

[2]   T. J. Sill and H. A. von Recum, “Electrospinning: Applications in Drug Delivery and Tissue Engineering,” Biomaterials, Vol. 29, No. 13, 2008, pp. 1989-2006. doi:10.1016/j.biomaterials.2008.01.011

[3]   D. H. Liang, B. S. Hsiao and B. Chu, “Functional Electrospun Nanofibrous Scaffolds for Biomedical Applications,” Advanced Drug Delivery Reviews, Vol. 59, No. 14, 2007, pp. 1392-1412. doi:10.1016/j.addr.2007.04.021

[4]   N. Ashammakhi, A. Ndreu, Y. Yang, H. Ylikauppila and L. Nikkola, “Applications in Drug Delivery and Tissue Engineering,” European Journal of Plastic Surgery, Vol. 29, No. 13, 2008, pp. 238-333.

[5]   H. S. Yoo, T. G. Kim and T. G. Park, “Surface-Functionalized Electrospun Nanofibers for Tissue Engineering and Drug Delivery,” Advanced Drug Delivery Reviews, Vol. 61, No. 12, 2009, pp. 1033-1042. doi:10.1016/j.addr.2009.07.007

[6]   M. Ma, R. M. Hill, J. L. Lowery, S. V. Fridrikh and Gregory C. Rutledge, “Electrospun Poly(Styrene-Block- Dimethylsiloxane) Block Copolymer Fibers Exhibiting Superhydrophobicity,” Langmuir, Vol. 21, No. 12, 2005, pp. 5549-5554. doi:10.1021/la047064y

[7]   S. Tungprapa, I. Jangchud, P. Ngamdee, M. Rutnakornpituk and P. Supaphol, “Surface-Functionalized Electrospun Nanofibers for Tissue Engineering and Drug Delivery,” Materials Letters, Vol. 60, No. 12, 2006, pp. 2920- 2924.

[8]   A. Alli, B. Hazer, Y. Menceloglu and S. Süzer, “Synthesis, Characterization and Surface Properties of Amphiphilic Polystyrene-b-Polypropylene Glycol Block Copolymers,” European Polymer Journal, Vol. 42, No. 4, 2006, pp. 740-750. doi:10.1016/j.eurpolymj.2005.09.032

[9]   I. L. Keranov, F. di Lena, M. Michel, A. Kostadinova, V. Toniazzo, D. Ruch and T. Vladkova, “Synthesis, Characterization and Self-Assembling Properties of Amphiphilic Block Copolymers of Poly(n-Vinyl Pyrrolidone) and Poly(dimethylsiloxane),” Journal of Applied Polymer Sci- ence, Submitted for Revision.

[10]   G. Altankov, “Interaction of Cells with Biomaterial Sur- faces,” D.Sc. Thesis, Institute of Biophysics, BAS, Sofia, 2003.

[11]   N. Nyanik, B. K?ker and Y. Yildiz, “Synthesis and Characterization of Poly(Dimethyl Siloxane) Containing Poly(Vinyl Pyrrolidinone) Block Copolymers,” Journal of Applied Polymer Science, Vol. 71, No. 11, 1999, pp. 1915-1922. doi:10.1002/(SICI)1097-4628(19990314)71:11<1915::AID-APP22>3.0.CO;2-D

 
 
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