Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications

Kathryn  Grandfield; Shiuli  Pujari; Marjam  Ott; Håkan  Engqvist; Wei  Xia

doi:10.4236/jbnb.2013.42014

Kathryn Grandfield, Shiuli Pujari, Marjam Ott, Håkan Engqvist, Wei Xia

Abstract: Increasing interest in the role of ions such as calcium and strontium in bone formation has called for the investigation of multifunctional ion-doped implant coatings. Mesoporous titania coatings incorporating calcium or strontium enabled a unique pore morphology and potential for drug delivery. Coatings were produced on titanium by an evaporation induced self-assembly method with the addition of calcium or strontium to the sol causing a shift in morphology from a hexagonally-packed to a worm-like porous network. Pore sizes ranged from 3.8 - 5 nm and coatings exhibited high surface areas between 181 - 215.5 m2/g, as measured by N2 adsorption-desorption. Coatings were loaded with 1 mg/ml Cephalothin, and showed sustained release of the antibiotic over one week in vitro. Cell studies confirmed that the ion addition had no toxic effect on human-like osteoblastic SaOS-2 cells. The results of this study suggest the potential for mesoporous coatings with calcium or strontium incorporation for direct bone-interfacing and combined drug delivery implant applications.

Keywords: Mesoporous; Titania; Calcium; Strontium; Drug Delivery; Bone; EISA

Cite this paper: K. Grandfield, S. Pujari, M. Ott, H. Engqvist and W. Xia, "Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications," Journal of Biomaterials and Nanobiotechnology, Vol. 4 No. 2, 2013, pp. 107-113. doi: 10.4236/jbnb.2013.42014.

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