IJOC  Vol.3 No.1 , March 2013
A Total and Convenient Synthesis of Orixiarine
Abstract: A simple total synthesis of the quinoline alkaloid, orixiarine was achieved from N-methylaniline and 1-bromo-3-methyl-2-butanone.
Cite this paper: T. Suresh, K. Velmurugan, P. Mohan and R. Nandhakumar, "A Total and Convenient Synthesis of Orixiarine," International Journal of Organic Chemistry, Vol. 3 No. 1, 2013, pp. 48-50. doi: 10.4236/ijoc.2013.31005.

[1]   Attaur-Rahman, M. N. Sultana, I. Choudhary, M. D. Shah and M. R. Khan, Journal of Natural Products, Vol. 61, 1998, p. 713.

[2]   J. P. Michael, “Quinoline, Quinazoline and Acridone Alkaloids,” Natural Product Reports, Vol. 20, No. 5, 2003, pp. 476-493. doi:10.1039/b208140g

[3]   K. M. Nadkarni, “Indian Materia Medica,” Popular Prakashan, Bombay, Vol. 1, 1976, p. 1142.

[4]   T. Noshita, M. Tando, K. Suzuki, K. Murata and S. Funayama, Bioscience, Biotechnology, and Biochemistry, Vol. 65, 2001, p. 710.

[5]   T. Namba, “Coloured Ilustrations of Wakanyaku (The crude Drugs in Japan, China and the Neighbouring countries),” Vol. 1 (in Japanese), Hoikusha Publishing Co. Ltd., Osaka, 1980, p. 148.

[6]   R. Nandhakumar, S. Thamarai Selvi, T. Suresh and P. S. Mohan, “A Synthesis of Orixiarine,” Heterocycles, Vol. 57, No. 2, 2002, pp. 357-360. doi:10.3987/COM-01-9413

[7]   M. F. Grundon, “The Alkaloids,” Vol. 32, Academic press, London, 1988, p. 341

[8]   L. A. Mitscher, G. W. Clark, T. Suzuki and M. S. Bathala, “A New Synthesis of Quinol-2,4-diones,” Heterocycles, Vol. 3, No. 11, 1975, pp. 913-919. doi:10.3987/R-1975-11-0913

[9]   P. Roschger and W. Stadlbaner, “Organic Azides in Heterocyclic Synthesis, 11. Ring Closure of 3-Acetyl-4-azido-2-quinolones to Isoxazolo[4,3-c]quinolones,” Liebigs Annalen der Chemie, Vol. 8, 1990, pp. 821-823. doi:10.1002/jlac.1990199001153

[10]   R. A. Corral, O. O. Orazi and J. C. Autino, “Total Synthesis of Phenolic Balfourodendron Alkaloids,” Tetrahedron Letters, Vol. 24, No. 23, 1983, pp. 2359-2360. doi:10.1016/S0040-4039(00)81924-3