IJOC  Vol.3 No.1 , March 2013
Synthesis and in Vitro Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates

N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.

Cite this paper
H. Sekkak, E. Rakib, M. Abdelouahid, A. Hafid and A. Malki, "Synthesis and in Vitro Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates," International Journal of Organic Chemistry, Vol. 3 No. 1, 2013, pp. 37-41. doi: 10.4236/ijoc.2013.31003.
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