Background: Accurate diagnosis of orofacial tumours is important as this determines the treatment options as well as the eventual treatment outcome. Agreement between clinical and histopathological diagnosis becomes important in this regard. Aims: The aim was to determine the level of agreement between clinical and histopathology diagnosis of orofacial lesions. Method: This is a retrospective study of all histopathology reports seen at KATH maxillofacial unit. Thedata collected included, clinical diagnosis and histological diagnosis. Results: A total of 567 histopathology reports were evaluated. The percentage of agreement between clinical and histopathological diagnosis was 62.8%. Conclusion: The agreement between clinical and histopathological diagnosis was high. However clinicians cannot rely on only the clinical diagnosis in managing patients.
 B. F. Adeyemi, L. V. Adekunle, B. M. Kolude, E. E. U. Akang and J. O. Lawoyin, “Head and Neck Cancer—A Clinicopathological Study in a Tertiary Care Center,” Journal of the National Medical Association, Vol. 100, No. 6, 2008, pp. 690-697.
 K. J. Patel, H. L. De Silva, D. C. Tong and R. M. Love, “Concordance between Clinical and Histopathologic Di- agnoses of Oral Mucosal Lesions,” Journal of Oral and Maxillofacial Surgery, Vol. 69, No. 1, 2011, pp. 125-133. doi:10.1016/j.joms.2010.07.075
 H. K. Williams, A. A. Hey and R. M. Browne, “The Use by General Dental Practitioners of an Oral Pathology Di- agnostic Service over a 20-Year Period: The Birmingham Dental Hospital Experience,” British Dental Journal, Vol. 182, 1997, pp. 424-429. doi:10.1038/sj.bdj.4809403
 J. Seoane, S. Warnakulasuriya, P. Varela-Centelles, G. Esparza and P. D. Dios, “Oral Cancer: Experiences and Diagnostic Abilities Elicited by Dentists in North-West- ern Spain,” Oral Diseases, Vol. 12, No. 5, 2006, pp. 487-492. doi:10.1111/j.1601-0825.2005.01225.x
 C. H. Siar, M. C. Mah and P. P. Gill, “Risk of the Contralateral Mucosa in Patients with Oral Potentially Malignant Disorders,” Asian Pacific Journal of Cancer Prevention, Vol. 12, No. 3, 2011, pp. 631-635.
 A. Jovanovic, P. J. Kostense, E. A. Schulten, G. B. Snow and I. van der Waal, “Delay in Diagnosis of Oral Squamous Cell Carcinoma: A Report from the Netherlands,” European Journal of Cancer Part B: Oral Oncology, Vol. 28B, No. 1, 1992, pp. 37-38. doi:10.1016/0964-1955(92)90009-P
 A. C. Begg, et al., “The Value of Pretreatment Cell Kinetic Parameters as Predictors for Radiotherapy Outcome in Head and Neck Cancer: A Multicenter Analysis,” Radiotherapy and Oncology, Vol. 50, No. 1, 1999, pp. 13-23.