Interim Positron-Emission Tomography (int-PET) and the peripheral blood absolute lymphocyte/monocyte ratio at di- agnosis (ALC/AMC-DX) have been shown to be predictors for progression-free survival (PFS) and time to progression (TTP) in classical Hodgkin lymphoma (cHL). Therefore, we studied if the combination of ALC/AMC-DX and the (int-PET) can further stratified PFS and TTP in cHL patients. Patients were required to be diagnosed, treated, and followed with int-PET at Mayo Clinic, Rochester, Minnesota. From 2000 until 2008, 111 cHL patients qualified for the study. The median follow-up was 2.8 years (range: 0.3 - 10.4 years). Patients with a negative int-PET (N = 98) pre- sented with a higher ALC/AMC-DX (median of 2.32, range: 0.26 - 37.5) compared with patients with a positive int-PET (N = 13) (median of 0.9, range: 0.29 - 3.10), p < 0.004. By multivariate analysis, ALC/AMC-DX and the int-PET were independent predictors for PFS and TTP, when compared with the International prognostic Score. Patients were stratified into four groups: group 1 included patients with a negative int-PET and ALC/AMC-DX ≥ 1.1; group 2 included positive int-PET and ALC/AMC-DX ≥ 1.1; group 3 included negative int-PET and ALC/AMC-DX < 1.1; and group 4 included positive int-PET and ALC/AMC-DX < 1.1. Group 1 experienced superior PFS and TTP in comparison with the other groups. In conclusion, the combination of ALC/AMC-DX and the int-PET provides a simple model to assess clinical outcomes in cHL.
 L. F. Porrata, K. Ristow, J. P. Colgan, T. M. Habermann, T. E. Witzig, D. J. Inwards, et al., “Peripheral Blood Lymphocyte/Monocyte Ratio at Diagnosis and Survival in Classical Hodgkin’s Lymphoma,” Hematologica, Vol. 97, No 2, 2012, pp. 262-269. doi:10.3324/haematol.2011.050138
 Y. W. Koh, H. J. Kang, C. Park, D. H. Yoon, S. Kim, et al., “The Ratio of the Absolute Lymphocyte Count to the Absolute Monocyte Count Is Associated with Prognosis in Hodgkin’s Lymphoma: Correlation with Tumor Associated Macrophages,” Oncologist, Vol. 17, No. 6, 2012, pp. 871-880.
 T. Terasawa, J. Lau, S. Bardet, O. Couturier, T. Hotta, M. Hutchings, et al., “Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography for Interim Response Assessment of Advanced-Stage Hodgkin’s Lymphoma and Diffuse Large B-Cell Lymphoma: A Systemic Review,” Journal of Clinical Oncology Vol. 27, No. 11, 2009, pp. 19061914. doi:10.1200/JCO.2008.16.0861
 A. Romano, C. Vetro, D. Donnarumma, S. Forte, M. Ippolito and F. Di Raimondo, “Early Interim 2-(1)Fluoro-2deoxy-D-glucose Positron Emission Tomography Is Prognostically Superior to Peripheral Blood Lymphocyte/Monocyte Ratio at Diagnosis in Classical Hodgkin’s Lymphoma,” Haematologica, Vol. 97, No. 6, 2012, pp. e22-e23. doi:10.3324/haematol.2012.064576
 C. J. Cox, T. M. Habermann, B. A. Payne, G. G. Klee, and R. V. Pierre. “Evaluation of the Coulter Counter Model S-Puls IV,” American Journal of Clinical Pathology, Vol. 84, No. 3, 1985, pp. 297-306.
 D. Hasenclever, V. Diehl, J. O. Armitage, D. Assouline, M. Bjorkholm, E. Brusamolino, et al., “A Prognostic Score for Advanced Hodgkin’s Disease,” New England Journal of Medicine, Vol. 339, No. 21, 1998, pp. 1506-1514. doi:10.1056/NEJM199811193392104
 B. D. Chelson, B. Pfistner, M. E. Juweid, R. D. Gascoyne, L. Specht, S. J. Horning, et al., “Revised Response Criteria for Malignant Lymphoma,” Journal of Clinical Oncology, Vol. 25, No. 5, 2007, pp. 579-586.
 E. Kaplan and P. Meier, “Nonparametric Estimation from Incomplete Observations,” Journal of the American Statistical Association Vol. 53, No. 282, 1958, pp. 457-481. doi:10.1080/01621459.1958.10501452