investigate the pathogenesis of a secondary iris cyst with an
immunohistochemical method.Methods: Single observational case report. A pathologic
specimen was obtained from a 5-year-old girl who was found to have a secondary
iris cyst. She had a history of previous penetrating ocular trauma and
subsequent cataract surgery and pupilloplasty. Immunohistochemical staining with cytokeratin (CK) 19 and CK3
was used.Results: After immunohistochemical staining, the inner wall
showed positive staining for CK19, which is specific for limbal, peripheral cornea
and conjunctival epithelium, and negative staining for CK3, which is specific
for corneal epithelium.Conclusions: With the aid of immunohistochemical
analysis, a conjunctival epithelial origin was indicated, and pupilloplasty was
identified as the causal event of the iris cyst while the possibility of
primary iris cyst was ruled out.
Cite this paper
J. Lee, S. Kim, E. Koh and J. Chang, "A Case of Secondary Iris Cyst AfterPupilloplasty*," Open Journal of Ophthalmology, Vol. 3 No. 1, 2013, pp. 13-15. doi: 10.4236/ojoph.2013.31004.
  F. A. Marigo and P. T. Finger, “Anterior Segment Tumors: Current Concepts and Innovations,” Survey of Ophthalmology, Vol. 48, No. 6, 2003, pp. 569-593.
 M. Küchle and W. R. Green, “Epithelial Ingrowth: A Study of 207 Histopathologically Proven Cases,” German Journal of Ophthalmology, Vol. 5, No. 4, 1996, pp. 211- 223.
 D. C. Cogan, “Experimental Implants of Conjunctiva into the Anterior Chamber,” American Journal of Ophthalmology, Vol. 39, No. 4, 1955, pp. 165-172.
 J. V. Jester, R. A. Villasenor and J. Miyashiro, “Epithelial Inclusion Cysts Following Radial Keratotomy,” Archives of Ophthalmology, Vol. 101, No. 4, 1983, pp. 611-615.
 T. Kivela, J. Jaaskelainen, A. Vaheri and O. Carpen, “Ezrin, a Membrane-Organizing Protein, as a Polarization Marker of the Retinal Pigment Epithelium in Vertebrates,” Cell and Tissue Research, Vol. 301, No. 2, 2000, pp. 217-223. doi:10.1007/s004410000225