The following work compared adverse effects profile and patients’ acceptability of intra-venous oxytocin 10 iu and oral misoprostol 600 ug used in the prevention of postpartum hemorrhage in the third stage of labour. A total of 1865 pregnant women who have received either oxytocin injection or oral misoprostol in third stage of labour as prophylaxis for postpartum haemorrhage, were enrolled within three health care facilities in Maiduguri, Nigeria. Each patient was observed at parturition and for 24 h after during which oral interviews were conducted and clinical notes studied. The oxytocin medication group exhibited higher abdominal pains (7.1% versus 0.0%; p < 0.001) and headache (1.9% versus 0.1%; p < 0.001), while the misoprostol group showed higher shivering (33.9% versus 0.0%; p < 0.001) and fever (19.7% versus 1.8%; p < 0.001). There were no significant differences in other side effects like nausea and vomiting. There was no statistically significant (p > 0.05) difference in patients acceptability of injectable oxytocin (99.3%) and oral misoprostol (98.3%). Oxytocin usage in the prevention of PPH was associated with abdominal pains and headache while misoprostol was associated with shivering and fever. Patients from this study have demonstrated high level of acceptability of both parenteral oxytocin and oral misopristol prevention of post-partum haemorrhage.
Cite this paper
Uthman, S. , Garba, M. , Danazumi, A. , Mandara, M. and Sylvester, N. (2013) Comparative study of the side effect profiles of oral misoprostol and parenteral oxytocin used in prevention of postpartum haemorrhage in Maiduguri Nigeria. Open Journal of Obstetrics and Gynecology
, 208-211. doi: 10.4236/ojog.2013.31A038
 Gulmezoglu, A.M., Villar, J., Ngoc, N.T., et al. (2001) Trial of misoprostol in the management of the third stage of labour. Lancet, 358, 689-695.
 Langenbach, C. (2006) Misoprostol in preventing postpartum hemorrhage: A meta-analysis. International Journal of Gynecology & Obstetrics, 92, 10-18.
 Ng, P.S., Chan, A.S., Sin, W.K., et al. (2001) A multicentre randomized controlled trial of oral misoprostol and im syntometrine in the management of the third stage of labour. Human Reproduction, 16, 31-35.
 Selo-Ojeme, D.O. (2002) Primary postpartum haemorrhage. Journal of Obstetrics and Gynecology, 22, 463-469. doi:10.1080/0144361021000003555
 Kodkany, B.S., Derman, R.J., Goudar, S.S., et al. (2004) Initiating a novel therapy in preventing postpartum hemorrhage in rural India: A joint collaboration between the United States and India. International Journal of Fertility and Women’s Medicine, 49, 91-96.
 Miller, S., Lester, F. and Hensleigh, P. (2004) Prevention and treatment of postpartum hemorrhage: New advances for low-resource settings. Journal of Midwifery & Women’s Health, 49, 283-292.
 Walraven, G., Blum, J., Dampha, Y., et al. (2005) Misoprostol in the management of the third stage of labour in the home delivery setting in rural Gambia: A randomized controlled trial. International Journal of Obstetrics & Gynaecology, 112, 1277-1283.
 Derman, R.J., Kodkany, B.S., Goudar, S.S., et al. (2006) Oral misoprostol in preventing postpartum haemorrhage in resource-poor communities: A randomised controlled trial. Lancet, 368, 1248-1253.
 JHPIEGO (2011) Program brief on maternal and neonatal health program preventing postpartum hemorrhage.
 Tang, O.S., Schweer, H., Seyberth, H.W., et al. (2002) Pharmacokinetics of different routes of administration of misoprostol. Human Reproduction, 17, 332-336.
 Hofmeyer, G.J., Nikodem, V.C. and De Jager, M. (1998) A randomized placebo controlled trial of oral misoprostol in the third stage of labour. British Journal of Obstetrics and Gynaecology, 105, 971-875.
 Amant, F., Spitz, B. and Timmerman, D. (1999) Misoprostol compared with methylergometrine for the prevention of postpartum haemorrhage. British Journal of Obstetrics and Gynaecology, 106, 1066-1070.
 El-Refaey, H., Nooh, R. and O’Brien, P. (2000) The misoprostol third stage of labour study. British Journal of Obstetrics and Gynaecology, 107, 1104-1110.
 WHO (2006) WHO Guidelines for the prevention of postpartum haemorrhage.
 Surbek, D.V., Fehr, P.M. and Hosli, I. (1999) Oral misoprostol for third stage of labor; a randomized placebocontrolled trial. Obstetrics and Gynaecology, 94, 255-258.
 Walley, R.L., Wilson, J.B. and Crane, J.M.G. (2000) A double-blind placebo controlled randomised trial of misoprostol and oxytocin in the management of the third stage of labour. British Journal of Obstetrics and Gynaecology, 107, 1111-1115. doi:10.1111/j.1471-0528.2000.tb11109.x
 El-Refaey, H., O’Brien, P. and Morafa, W. (1996) Misoprostol for the third stage of labor. Lancet, 347, 1257.
 El-Refaey, H., O’Brien, P. and Morafa, W. (1997) Use of misoprostol in the prevention of postpartum hemorrhage. British Journal of Obstetrics and Gynaecology, 104, 336-339. doi:10.1111/j.1471-0528.1997.tb11464.x
 Bamigboye, A.A., Merrell, D.A. and Hofmeyer, G.J. (1998) Randomized comparison of rectal misoprostol with syntometrine for the management of the third stage of labor. Acta Obstetricia et Gynecologica Scandinavica, 77, 178-181. doi:10.1080/j.1600-0412.1998.770209.x
 Diab, K.M., Ramy, A.R. and Yehia, M.A. (1999) The use of rectal misoprostol in 140 subjects as active pharmacological management of the third stage of labor. Journal of Obstetrics and Gynaecology Research, 25, 327-332.
 Zieman, M., Fong, S.K. and Benonitz, N.L. (1997) Kinetics of misoprostol with oral or vaginal administration. Obstetrics & Gynecology, 90, 88-92.