ABSTRACT Introduction: Breast involvement by non-Hodgkin lymphoma is particularly rare in women. We describe the case of a patient with a rapidly growing, nodule in the right breast. On ultrasonography, the nodule was suspicious for breast carcinoma. Case presentation: A breast biopsy from a 73-year-old Moroccan women answered invasive ductal carcinoma grade 3 from Elston and Ellis. Patey was performed. Microscopic examination showed lymphoid proliferation confirmed on immunohistochemical analysis. Our patient was treated with chemotherapy. Conclusions: The rarity of breast lymphomas, and the problems related to the diagnosis and therapeutic choices with these tumors require molecular techniques in association with classical histological diagnosis.
Cite this paper
El Fatemi, H., Souaf, I., El Jayi, S., Moumna, K., Melhouf, M., Sqali, N. and Amarti, A. (2013) Diagnosis Error: Carcinoma or Primary Breast Lymphoma? A Case Report and Literature Review. Advances in Breast Cancer Research, 2, 11-14. doi: 10.4236/abcr.2013.21003.
 W. Jeanneret-Sozzi, A. Taghian, R. Epelbaum, et al., “Primary Breast Lymphoma: Patient Profile, Outcome and Prognostic Factors. A Multicentre Rare Cancer Network Study,” BMC Cancer, Vol. 8, 2008, p. 86.
 C. S. Ha, P. Dubey, L. K. Goyal, M. Hess, F. Cabanillas and J. D. Cox, “Localized Primary Non-Hodgkin Lymphoma of the Breast,” American Journal of Clinical Oncology, Vol. 21, No. 4, 1998, pp. 376-380.
 D. Meerkotter, G. Rubin, F. Joske, P. Angunawela and A. Khalafallah, “Primary Breast Lymphoma: A Rare Entity,” Journal of Radiology Case Reports, Vol. 5, No. 5, 2011, pp. 1-9.
 M. Topalovski, D. Crisan and J. C. Mattson, “Lymphoma of the Breast. A Clinicopathologic Study of Primary and Secondary Cases,” Archives of Pathology & Laboratory Medicine, Vol. 123, No. 12, 1999, pp. 1208-1218.
 K. Ganjoo, R. Advani, M. R. Mariappan, A. McMillan and S. Horning, “Non-Hodgkin Lymphoma of the Breast,” Cancer, Vol. 110, No. 1, 2007, pp. 25-30.
 G. Ryan, G. Martinelli, M. Kuper-Hommel, et al., “Primary Diffuse Large B-Cell Lymphoma of the Breast: Prognostic Factors and Outcomes of a Study by the International Extranodal Lymphoma Study Group,” Annals of Oncology, Vol. 19, No. 2, 2008, pp. 233-241.
 S. H. Kim, M. P. Ezekiel and R. Y. Kim, “Primary Lymphoma of the Breast: Breast Mass as an Initial Symptom,” American Journal of Clinical Oncology, Vol. 22, No. 4, 1999, pp. 381-383.
 A. H. Dao, R. B. Adkins Jr. and A. D. Glick, “Malignant Lymphoma of the Breast: A Review of 13 Cases,” The American Journal of Surgery, Vol. 58, No. 12, 1992, pp. 792-796.
 J. R. Zack, S. G. Trevisan and M. Gupta, “Primary Breast Lymphoma Originating in a Benign Intramammary Lymph Node,” American Journal of Roentgenology, Vol. 177, No. 1, 2001, pp. 177-178.
 W. C. Jennings, R. S. Baker, S. S. Murray, et al., “Primary Breast Lymphoma: The Role of Mastectomy and the Importance of Lymph Node Status,” Annals of Surgery, Vol. 245, No. 5, 2007, pp. 784-789.
 C. Y. Lyou, S. K. Yang, D. H. Choe, B. H. Lee and K. H. Kim, “Mammographic and Sonographic Findings of Primary Breast Lymphoma,” Clinical Imaging, Vol. 31, No. 4, 2007, pp. 234-238. doi:10.1016/j.clinimag.2007.02.028
 R. Franco, A. Fernández-Vázquez, M. Mollejo, M. A. Cruz, F. I. Camacho, J. F. García, M. Navarrete and M. A. Piris, “Cutaneous Presentation of Follicular Lymphomas,” Modern Pathology, Vol. 14, No. 9, 2001, pp. 913-919. doi:10.1038/modpathol.3880411
 A. Fattaneh, Tavassoli, P. Deville, et al., “Tumours of the Breast and Female Genital Organs. Pathology and Genitics,” International Agency for Research on Cancer, Lyon, 2004.
 M. H. Lbrahim and S. Singletary, “Surgical Management of Primary Lymphoma of the Breast,” Annals of Surgery, Vol. 214, No. 6, 1991, pp. 724-726.
 T. P. Miller, S. Dahlberg, J. R. Cassady, et al., “Chemotherapy alone Compared with Chemotherapy plus Radiotherapy for Localized Intermediate- and High-Grade Non- Hodgkin’s Lymphoma,” The New England Journal of Medicine, Vol. 339, 1998, pp. 21-26.