The recombinant third domain of alpha-fetoprotein
(AFP3D) is one of the promising vectors for targeted delivery of anticancer
drugs to tumor cells. AFP3D-based conjugates with various anti-tumor agents
have shown specific anti-tumor activity. The content of anti-tumor drugs in the
preparation could be increased by including dendrimers - highly branched
nanoparticles - into a targeted delivery system. In this study, we synthesized
the AFP3D conjugate with doxorubicin-loaded poly(amidoamine) (PAMAM) dendrimer
nanoparticles and investigated its cytotoxic activity.
Cite this paper
S. Kisil, V. Chernikov, M. Danilevskiy, L. Savvateeva and N. Gorokhovets, "Conjugation of the Recombinant Third Domain of Human Alpha-fetoprotein with Doxorubicin Using Poly(amidoamine) Dendrimers and Study of Its Cytotoxic Activity," Engineering, Vol. 4 No. 10, 2012, pp. 80-83. doi: 10.4236/eng.2012.410B021.
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