Coacervation Microencapsulation of CaCO3 Particles with a Fluoropolymer by Pressure-induced Phase Separation of Supercritical Carbon Dioxide Solutions
Author(s)
Kenji Mishima*,
Haruo Yokota,
Takafumi Kato,
Tadashi Suetsugu,
Xiuqin Wei,
Keiichi Irie,
Kenichi Mishima,
Michihiro Fujiwara
Affiliation(s)
Department of Chemical Engineering,Fukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Chemical EngineeringFukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Electronics Engineering and Computer ScienceFukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Electronics Engineering and Computer Science, Fukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Neuropharmacology, Fukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan.
Department of Chemical Engineering,Fukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Chemical EngineeringFukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Electronics Engineering and Computer ScienceFukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Electronics Engineering and Computer Science, Fukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan. Department of Neuropharmacology, Fukuoka University, 8-19-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan.
ABSTRACT
We report a method for the coacervation micro-encapsulation of several forms of CaCO3 microparticles with the fluoropolymer poly(heptadecafluorodecyl acrylate) (poly (HDFDA)) by pressure-induced phase separation of a supercritical CO2 solution. A suspension of CaCO3 in CO2 and dissolved poly(HDFDA) were mixed in supercritical CO2. After the system pressure was slowly decreased to atmospheric pressure, the microcapsules were obtained. Coacervation was achieved by the precipitation of poly(HDFDA) during the decrease in the pressure of CO2; the solubility of poly(HDFDA) in CO2 decreased with the pressure. The structure and morphology of the microparticles were investigated by using a scanning electron microscope (SEM) and an electron probe microanalyzer (EPMA) equipped with a wavelength dispersive X-ray spectroscope (WDX).
We report a method for the coacervation micro-encapsulation of several forms of CaCO3 microparticles with the fluoropolymer poly(heptadecafluorodecyl acrylate) (poly (HDFDA)) by pressure-induced phase separation of a supercritical CO2 solution. A suspension of CaCO3 in CO2 and dissolved poly(HDFDA) were mixed in supercritical CO2. After the system pressure was slowly decreased to atmospheric pressure, the microcapsules were obtained. Coacervation was achieved by the precipitation of poly(HDFDA) during the decrease in the pressure of CO2; the solubility of poly(HDFDA) in CO2 decreased with the pressure. The structure and morphology of the microparticles were investigated by using a scanning electron microscope (SEM) and an electron probe microanalyzer (EPMA) equipped with a wavelength dispersive X-ray spectroscope (WDX).
Cite this paper
K. Mishima, H. Yokota, T. Kato, T. Suetsugu, X. Wei, K. Irie, K. Mishima and M. Fujiwara, "Coacervation Microencapsulation of CaCO3 Particles with a Fluoropolymer by Pressure-induced Phase Separation of Supercritical Carbon Dioxide Solutions," Advances in Materials Physics and Chemistry, Vol. 2 No. 4, 2012, pp. 181-184. doi: 10.4236/ampc.2012.24B047.
K. Mishima, H. Yokota, T. Kato, T. Suetsugu, X. Wei, K. Irie, K. Mishima and M. Fujiwara, "Coacervation Microencapsulation of CaCO3 Particles with a Fluoropolymer by Pressure-induced Phase Separation of Supercritical Carbon Dioxide Solutions," Advances in Materials Physics and Chemistry, Vol. 2 No. 4, 2012, pp. 181-184. doi: 10.4236/ampc.2012.24B047.
References
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[1] J. Jung and M. Perrut, “Particle design using supercritical fluids: Literature and patent survey,” The Journal of Supercritical Fluids, vol. 20, no. 3, pp.179-219, 2001. J. Clerk Maxwell, A Treatise on Electricity and Magnetism, 3rd ed., vol. 2. Oxford: Clarendon, 1892, pp.68–73. [2] S. D. Yeo and E. Kiran, “Formation of polymerparticles with supercriticalfluids: A review,” The Journal of Supercritical Fluids, vol. 34, no. 3, pp. 287-308, 2005. [3] E. Reverchon and R. Adami, “Nanomaterials and supercriticalfluids,” The Journal of Supercritical Fluids, vol. 37, no. 1, pp. 1-22, 2006. [4] J.W.Tom, P.G. Debenedetti, R. Jerome, “ Precipitation of Poly(L-lactic acid) and Composite Poly(L-lactic acid)-Pyrene Particles by Rapid Expansion of Supercritical Solutions.” J. Supercritical Fluids vol.7, 9,1994. [5] K. Mishima, K. Matsuyama, D. Tanabe, S. Yamauchi, T. J. Young, and K. P. Johnston, “Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent,” AIChE Journal, vol. 46, no. 4, pp. 857-865, 2000. [6] K. Mishima,”Biodegradable particle formation for drug and gene delivery using supercritical fluid and dense gas, “Advanced Drug Delivery Reviews, vol. 60, no. 3, pp. 411-432, 2008. [7] K. Matsuyama, K. Mishima, K. Hayashi, and H. Matsuyama, “Microencapsulation of TiO2 Nanoparticles with Polymer by Rapid Expansion of Supercritical Solution,” Journal of Nanoparticle Research, vol. 5, no. 1-2, pp. 87-95, 2003. [8] K. Matsuyama, K. Mishima, K. I. Hayashi, H. Ishikawa, H. Matsuyama, and T. Harada, “Formation of microcapsules of medicines by the rapid expansion of a supercritical solution with a nonsolvent,” Journal of Applied Polymer Science, vol. 89, no. 3, pp. 742-752, 2003. [9] K. Matsuyama and K. Mishima, “Coacervation microencapsulation of talc particles with a fluoropolymer by pressure-induced phase separation of supercritical carbon dioxide solutions,” Industrial and Engineering Chemistry Research, vol, 45, no. 18, pp. 6462-6168, 2006. [10] DeSimone, J. M.; Guan, Z.; Elsbernd, C. S. Synthesis of Fluoropolymers in Supercritical Carbon Dioxide. Science 257, 945-946,1992. [11] Chernyak, Y.; Henon, F.; Harris, R. B.; Gould, R. D.; Franklin, R. K.; Edwards, J. R.; DeSimone, J. M.; Carbonell, R. G. Formation of Perfluoropolyether Coatings by the Rapid Expansion of Supercritical Solutions (RESS) Process. Part 1: Experimental Results. Ind. Eng. Chem. Res. 2001, 40, 6118.. [12] Blasig, A.; Shi, C. M.; Enick, R. M.; Thies, M. C. Effect of Concentration and Degree of Saturation on RESS of a CO2-soluble Fluoropolymer. Ind. Eng. Chem. Res. 2002, 41, 4976. [13] Mawson, S.; Johnston, K. P.; Combes, J. R.; DeSimone, J. M. Formation of Poly(1,1,2,2-tetrahydroperfluorodecyl acrylate) Submicron Fibers and Particles from Supercritical Carbon Dioxide Solutions. Macromolecules 1995, 28, 3182. [14] Luna-Barcenas, G.; Mawson, S.; Takishima, S.; DeSimone, J. M.; Sanchez, I. C.; Johnston, K. P. Phase Behavior of Poly(1,1-dihydroperfluorooctylacrylate) in Supercritical Carbon Dioxide. Fluid Phase Equilibria 1998, 146, 325. [15] Calvo, L.; Holmes, J. D.; Yates, M. Z.; Johnston, K. P. Steric Stabilization of Inorganic Suspensions in Carbon Dioxide. J. Supercritical Fluids 2000, 16, 247. [16] J. Lazko, Y. Popineau, J. Legrand, Soy Glycinin Microcapsules by Simple Coacervation Method. Colloids and Surfaces B: Biointerfaces 2004, 37, 1.