ABSTRACT Introduction and Objectives: Sinonasal tumours represent only 3% of all head and neck cancers. Adenocarcinoma is the second most frequent histopathology type. Hardwood exposure has been considered a risk factor. Sinonasal adenocarcinoma grows silently which leads to a late diagnosis and low survival rates. The aim of this study was to present our experience in the management of the patients with sinonasal adenocarcinoma.Method: Retrospective medical records review of patients with sinonasal adenocarcinomas (1974 to 2009). Results: From 301 patients with sinonasal tumors, 67 had histology of adenocarcinoma. Patient average age was 60.1±11.1 years (30-84 years). 83.6% were man. 65.7% had history of working with wood. 70.1% of the patients had advance disease. The most common treatment strategy was external surgery (lateral rhinotomy (47.8%), sublabial (17.9%) or cranio-facial resection (6%)) or endoscopic approaches with postoperative radiotherapy. The 3 and 5 years overall survival rate were 60% and 49%, respectively.Conclusions: Our group study showed similar epidemiologic characteristics than other series. We confirmed sinonasal adenocarcinomas tendency to late diagnosis and wood dust exposure relation. In our experience, the limited surgical treatment (without craniofacial resection) and postoperative radiotherapy has good survival rates results, similar to other departments who consider the craniofacial resection as the standard treatment.
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T. Bernardo, E. Ferreira, J. Silva and E. Monteiro, "Sinonasal Adenocarcinoma—Experience of an Oncology Center," International Journal of Otolaryngology and Head & Neck Surgery, Vol. 2 No. 1, 2013, pp. 13-16. doi: 10.4236/ijohns.2013.21005.
 P. P Knegt, K. W. Ah-See, L. A. Velden and J. Kerrebijn, “Adenocarcinoma of the Ethmoidal Sinus Complex: Surgical Debulking and Topical Fluorouracil May Be the Optimal Treatment,” Archives of Otolaryngology—Head & Neck Surgery, Vol. 127, No. 2, 2001, pp. 141-146.
 B. A. McMonagle and M. Gleeson, “Nasal Cavity and Paranasal Sinus Malignancy,” In: M. G. Scott-Brown, Otorhinolaryngology, Head and Neck Surgery, 7th Edition, Edward Arnold Publishers Ltd., Londres, 2008, pp. 2417-2436.
 G. Gatta, G. Bimbi, L. Ciccolallo, G. Zigon, G. Cantú and EUROCARE Working Group, “Survival for Ethmoid Sinus Adenocarcinoma in European populations,” Acta Oncologica, Vol. 48, No. 7, 2009, pp. 992-998.
 I. Leivo, “Update on Sinonasal Adenocarcinoma: Classification and Advances in Immunophenotype and Molecular Genetic Make-Up,” Head and Neck Pathology, Vol. 1, No. 1, 2007, pp. 38-43.
 J. H. Kuijpens, M. W. Louwman, R. Peters, G. O. Janssens, A. L. Burdorf and J. W. Coebergh, “Trends in Sinonasal Cancer in the Netherlands: More Squamous Cell Cancer, Less Adenocarcinoma: A Population-Based Study 1973-2009,” European Journal of Cancer, Vol. 48, No. 15, 2012, pp. 2369-2374.
 J. H. Turner and D. D. Reh, “Incidence and Survival in Patients with Sinonasal Cancer: A Historical Analysis of Population-Based Data,” Head and Neck, Vol. 34, No. 6, 2012, pp. 877-885. doi:10.1002/hed.21830
 J. L. Llorente, F. Nú?ez, J. P. Rodrigo, R. Fernández León, C. Alvarez, M. Hermsen, et al., “[Sinonasal Adeno-Car-Cinomas: Our Experience],” Acta Otorrinolaringológica Espa?ola, Vol. 59, No. 5, 2008, pp. 235-238
 A. d'Errico, S. Pasian, A. Baratti, R. Zanelli, S. Alfonzo, L. Gilardi, et al., “A Case-Control Study on Occupational Risk Factors for Sino-Nasal Cancer,” Occupational and Environmental Medicine, Vol. 66, No. 7, 2009, pp. 448- 455. doi:10.1136/oem.2008.041277
 R. Breheret, L. Laccourreye, C. Jeufroy and A. Bizon, “Adenocarcinoma of the Ethmoid Sinus: Retrospective Study of 42 Cases,” European Annals of Otorhinolaryngology, Head and Neck Diseases, Vol. 128, No. 5, 2011, pp. 211-217. doi:10.1016/j.anorl.2011.02.012
 E. Hanna, F. DeMonte, S. Ibrahim, D. Roberts, N. Levine and M. Kupferman, “Endoscopic Resection of Sinonasal Cancers with and without Craniotomy: Oncologic Results,” Archives of Otolaryngology—Head & Neck Surgery, Vol. 135, No. 12, 2009, pp. 1219-1224.
 V. J. Lund, D. J. Howard, W. I. Wei and A. D. Cheesman, “Craniofacial Resection for Tumor of the Nasal Cavity and Paranasal Sinuses: A 17-Year Experience,” Head and Neck, Vol. 20, No. 2, 1998, pp. 97-105.
 J. P. Shah, D. H. Kraus, M. H. Bilsky, P. H. Gutin, L. H. Harrison and E. W. Strong, “Craniofacial Resection for Malignant Tumors Involving the Anterior Skull Base,” Archives of Otolaryngology—Head & Neck Surgery, Vol. 123, No. 12, 1997, pp. 1312-1317.
 D. Salvan, M. Julieron, P. Marandas, F. Janot, A. M. Leridant, C. Domenge, et al., “Combined Transfacial and Neurosurgical Approach to Malignant Tumors of the Ethmoid Sinus,” The Journal of Laryngology & Otology, Vol. 112, No. 5, 1998, pp. 446-450.
 G. Cantu, C. L. Solero, R. Miceli, F. Mattana, S. Riccio, S. Colombo, et al., “Anterior Craniofacial Resection for Malignant Paranasal Tumors: A Monoinstitutional Experience of 366 Cases,” Head and Neck, Vol. 34, No. 1, 2012, pp. 78-87. doi:10.1002/hed.21685
 I. Ganly, S. G. Patel, B. Singh, D. H. Kraus, P. G. Bridger, G. Cantu, et al., “Craniofacial Resection for Malignant Paranasal Sinus Tumors: Report of an International Collaborative Study,” Head and Neck, Vol. 27, No. 7, 2005, pp. 575-584. doi:10.1002/hed.20165
 Y. Chu, H. G. Liu and Z. K. Yu, “Patterns and Incidence of Sinonasal Malignancy with Orbital Invasion,” Chinese Medical Journal (English Edition), Vol. 125, No. 9, 2012, pp. 1638-1642.
 R. H. Jesse, “Preoperative versus Postoperative Radiation in the Treatment of Squamous Carcinoma of the Nasal Sinus,” The American Journal of Surgery, Vol. 110, No. 4, 1965, pp. 552-556.