It is represented the review about the effect of low doses of ionized radiation on different types of biological objects (Japanese quail embryos, Aspergillus niger, Spirostomum ambiguum Ehrbg., mezenchim stem cells of mice bone brain, dry seeds of the highest plants, blood lymphocytes of pilots and cosmonauts) and water medium. In model experiments under the chronic ionized radiation in doses comparable with the doses of ionized radiation inside the orbital space stations and during the flight in interplanetary space was shown alike with morphological deviations (Japanese quail embryos, Aspergillus niger), the phenomenon of radiation hormezis (Aspergillus niger, mezenchim stem cells), the increasing of the germination of seeds, the decreasing of spontaneous motion activity of spirostoms and DNA damage, chromosome aberrations and the increased radio-sensitivity to adding radiation load in blood lymphocytes. These data testified the fact that the definite factor of ionized radiation effect is the changing of water medium state. Thus under the interplanetary cosmic flight and long stay on the orbit in the region of magnetosphere the studying kinds of radiation first effected on the water medium of organism as a result morpho-functional structures were changed.
 Pelevina, I.I., Aleschenko, A.V., Gotlib, V.Ya., et al. (2005) Reaction of blood lymphocytes of individual with somatic diseases on the radiation effect in low doses. Journal of Radiation Biology, 45, 412-415.
 Tsetlin, V.V., Zenin, S.V., Golovkina, T.V., et al. (2003) Role of water medium in the mechanism of the effect of super-low doses of ionized radiation. Journal of Bio- medical Technologies and Radio-Electronic, 12, 20-25.
 Graevsky, E.L., Detlaf, T.A. and Mednikov, B.M. (1977) Regularities of individual animal development and con- trol of ontogenesis processes. In: Graevskiy, E.L., Ed., Problems of the Biology Development. Environment and the Developing Organism. TSHA, Moscow, 91-125.
 Tsetlin, V.V., Bondarenko, V.A., Viktorov, A.N., et al. (2002) Variations of radiation situation and the develop- ment of microbial association on OC “MIR” depend on solar activity. Atlas of the temporal variations of nature, anthropogenic and social processes, Ianus-K, Moscow, 3, 556-560.
 Tsetlin, V.V., Bondarenko, V.A., Deshevaya, E.A., et al. (2001) The results of the investigations of the effect of radiation conditions on the environment of orbit station and the perspectives of using it for the decision of earthly ecological tasks. Proceedings of the Scientific Readings Devoted to the 40th Annual of the First Man Flight in Cosmos, Moscow, 12 April 2001, 16-18.
 Tsetlin, V.V. and Deshevaya, E.A. (2003) The effect of chronic irradiation by low doses of cosmic ionized radia- tion on the character of microbial association forming in the environment of orbit stations. Journal of Radiation Biology and. Radioecology, 43, 172-175.
 Tsetlin, V.V., Levinskich, M.A., Nefedova, E.L. et al. (2008) Effect of low doses of ionized radiation on water substrate and the development of high plant seeds. Jour- nal of Avia-Cosmic and Ecological Medicine, 3, 18-22.
 Meleshko, G.I., Shepelev, E. Ya., Gurieva, T.S., et al. (1991) Embrional development of birds under the condi- tions of weightnessless. Journal of Cosmic Biology and Avia-Cosmic Medicine, 1, 37-39..
 Gurieva, T.S., Dadasheva, O.A., Tsetlin, V.V., et al. (2007) Effect of chronic irradiation by low doses of ionized radiation on embrional development of Japanese quail. Journal of Avia-Cosmic and Ecological Medicine, 1, 20-24.
 Domaratskaia, E.I., Starostin, V.I., Tsetlin, V.V., et al. (2003) Effect of 10-daily γ-radiation in low doses on mice bone brain cells. Journal of Radiation Biology and. Ra- dioecology, 43, 213-215.
 Snyder, A.R. and Morgan, W.F. (2004) Radiation-induc- ed chromosomal instability and gene expression profiling: Searching for clues to initiation and perpetuation. Muta- tion Research, 568, 89-96. doi:10.1016/j.mrfmmm.2004.06.048
 Mazuric, V.K. and Michailov, V.F. (2001) Radiation- induced instability of genome: Phenomena, molecular mechanisms, pathogenetic significant. Journal of Radia- tion Biology and Radioecology, 41, 272-289.
 Sevan’kaev, A.V., Michailova, G.F., Potetnya, O.I., et al. (2005) Results of dynamic cytogenetic observation for the children and teenagers living on the territories of ra- diation pollution after Chernobyl catastrophe. Journal of Radia- tion Biology and Radioecology, 45, 5-15.
 Morgan, W.F. (2003) Is there a common mechanism underlying genomic instability, bystander effects and other non-targeted effects of exposure to ionizing radia- tion? Oncogene, 22, 7094-7099. doi:10.1038/sj.onc.1206992
 Pelevina, I.I., Afanas’ev, G.G., Aleschenko, A.V., et al. (1999) Radio-induced adaptive answer in children and ef- fect on it some outer and inner factors. Journal of Radia- tion Biology and Radioecology, 39, 106-112.
 Preston, D.L., Shimizu, Y., Pierce, D.A., et al. (2003) Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and non-cancer disease mortality: 1950- 1997. Radiation Research, 160, 381-407. doi:10.1667/RR3049
 Ivanov, V.K., Maksutov, M.A., Chekin, S. Yu., et al. (2005) Risk of cerebro-vascular diseases among the liq- uidators of the ChAES catastrophe. Journal of Radia- tion Biology and Radioecology, 45, 261-270.
 Pelevina, I.I., Antoschina, M.M., Bondarenko, V.A., et al. (2007) Individual cytogenetic and molecular-biological peculiarities of blood lymphocytes of pilots and cosmo- nauts. Journal of Radiation Biology and Radioecology, 47, 141-150.
 Zenin, S.V. (1995) Mechanism of the effect of superlow doses via the alteration of informational system of water. Proceedings of the 2nd International Symposium: Mech- anisms of the Effect of Superlow Doses, Moscow, 23-26 May 1995, 94-95.
 Tsetlin, V.V. and Fineshtein, G.S. (2012) About the effect of cosmophysic, geophysic and radiation factors on the electro-physic and biological water properties. Journal of Metaphysics, 2, 81-99.
 Tsetlin, V.V., Artamonov, A.A., Bondarenko, V.A. and Fedotova, I.V. (2008) About temporal currents variations of water conductivity in electrochemical cell. Journal of Solar-Earth Physics, 2, 361-363.
 Tsetlin, V.V., Zenin, S.V. and Lebedeva, N.E. (2005) Mechanism of the effect of superlow doses of ionized radiation on water medium. Journal of Biomedical Technology and Radioelectronics, 6, 53-57.