NM  Vol.3 No.4 , December 2012
Pituitary-Thyroid Dysfunction in a Hashimoto’s Encephalopathy Patient
ABSTRACT

The pathogenesis of Hashimoto’s encephalopathy has not been clearly elucidated and involvement of autoimmune damage has been proposed. We report a 23-year-old man who was emergently hospitalized for paroxysmal syncope and involuntary tremor with normal physical examination except for low heart rate. The patient was characterized by neurological symptoms, mild hypothyroidism, enlarged pituitary gland and extremely elevated thyrotropin, which all were reversed with levothyroxine alone. The case indicated that the pituitary-thyroid dysfunction may play a role in the pathogenesis of Hashimoto’s encephalopathy, hence, evaluation of pituitary gland should be recommended in diagnosis and treatment of Hashimoto’s encephalopathy.


Cite this paper
J. Hu, J. He and M. Zhang, "Pituitary-Thyroid Dysfunction in a Hashimoto’s Encephalopathy Patient," Neuroscience and Medicine, Vol. 3 No. 4, 2012, pp. 354-356. doi: 10.4236/nm.2012.34042.
References
[1]   R. J. Caselli, J. F. Drazkowski and D. M. Wingerchuk, “Autoimmune Encephalopathy,” Mayo Clinic Proceedings, Vol. 85, No. 10, 2010, pp. 878-880.

[2]   G. A. Marshall and J. J. Doyle, “Long-Term Treatment of Hashimoto’s Encephalopathy,” Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 18, No. 1, 2006, pp. 14-20. doi:10.1176/appi.neuropsych.18.1.14

[3]   S. Melmed, K. S. Polonsky, P. R. Larsen and H. M. Kronenberg, “Williams Textbook of Endocrinology, 12th Edition,” In: Gregory A. Brent and Terryf. Davies, Ed., Hypothyroidism and Thyroiditis, Elsevier Saunders, Inc., Philadelphia, 2011, pp. 410.

[4]   N. J. Sarlis, F. Brucker-Davis, J. L. Doppman and M. C. Skarulis, “MRI-Demonstrable Regression of a Pituitary Mass in a Case of Primary Hypothyroidism after a Week of Acute Thyroid Hormone Therapy,” Journal of Clinical Endocrinology and Metabolism, Vol. 82, No. 3, 1997, pp. 808-811.

[5]   S. Fukata, G. A. Brent and M. Sugawara, “Resistance to Thyroid Hormone in Hashimoto’s Thyroiditis,” New England Journal of Medicine, Vol. 352, No. 5, 2005, pp. 517-518.

[6]   K. W. Nolte, A. Unbehaun, H. Sieker, T. M. Kloss and W. Paulus, “Hashimoto Encephalopathy: A Brainstem Vasculitis?” Neurology, Vol. 54, No. 3, 2000, pp. 769-770. doi:10.1212/WNL.54.3.769

[7]   J. Y. Chong, L. P. Rowland and R. D. Utiger, “Hashimoto Encephalopathy, Syndrome or Myth?” Archives of Neurology, Vol. 60, No. 2, 2003, pp. 164-171.

[8]   P. Striano, M. Pagliuca, V. Andreone, F. Zara, A. Coppola and S. Striano, “Unfavourable Outcome of Hashimoto Encephalopathy Due to Status Epilepticus: One Autopsy case,” Journal of Neurology, Vol. 253, No. 2, 2006, pp. 248-249. doi:10.1007/s00415-005-0925-6

[9]   N. Schiess and C. A. Pardo, “Hashimoto’s Encephalopathy,” Annals of the New York Academy of Sciences, Vol. 1142, 2008, pp. 254-265. doi:10.1196/annals.1444.018

 
 
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