ABSTRACT Platelet rich plasma (PRP) contains a high concentration of thrombocytes and the a granules of platelets contain platelet released growth factors. The usefulness of PRP for regeneration of bone and soft tissues has been reported previously. We firstly reported the efficacy of PRP prepared using the Magellan Autologous Platelet Separator System for intractable skin ulcers such as diabetic and venous ulcers. The system consists of a microprocessor controlled centrifuge, syringe pumps, and necessary single use processing components. No complications occurred in any patients and the wounds achieved complete epithelialization. Our results have shown the efficiency of platelet rich plasma for the treatment of intractable skin ulcers.
Cite this paper
Kakudo, N., Kushida, S., Ogura, T., Hara, T., Suzuki, K. and Kusumoto, K. (2012) The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series. Open Journal of Regenerative Medicine, 1, 29-32. doi: 10.4236/ojrm.2012.13005.
 Martin, P. (1997) Wound healing—Aiming for perfect skin regeneration. Science, 276, 75-81.
 Kakudo, N., Minakata, T., Mitsui, T., Kushida, S., Noto- dihardjo, F.Z. and Kusumoto, K. (2008) Proliferation-pro- moting effect of platelet-rich plasma on human adipose- derived stem cells and human dermal fibroblasts. Plastic and Reconstructive Surgery, 122, 1352-1360.
 Moreo, K. (2005) Understanding and overcoming the challenges of effective case management for patients with chronic wounds. The Case Manager, 16, 62-67.
 Mustoe, T. (2004) Understanding chronic wounds: A uni- fying hypothesis on their pathogenesis and implications for therapy. American Journal of Surgery, 187, 65S-70S.
 Brady, C., Vang, S., Christensen, K., Isler, J., Vollstedt, K. and Holt, D. (2006) Use of autologous platelet gel in bari- atric surgery. The Journal of Extra-Corporeal Technology, 38, 161-164.
 Kakudo, N., Kushida, S., Minakata, T., Suzuki, K. and Kusumoto, K. (2011) Platelet-rich plasma promotes epi- thelialization and angiogenesis in a splitthickness skin graft donor site. Medical Molecular Morphology, 44, 233- 236. doi:10.1007/s00795-010-0532-1
 Knighton, D.R., Ciresi, K.F., Fiegel, V.D., Austin, L.L. and Butler, E.L. (1986) Classification and treatment of chronic nonhealing wounds. Successful treatment with au- tologous platelet-derived wound healing factors (PDWHF). Annals of Surgery, 204, 322-330.
 Vang, S.N., Brady, C.P., Christensen, K.A., Allen, K.R., Anderson, J.E., Isler, J.R., Holt, D.W. and Smith, L.M. (2007) Autologous platelet gel in coronary artery bypass grafting: Effects on surgical wound healing. The Journal of Extra-Corporeal Technology, 39, 31-38.
 Englert, S.J., Estep, T.H. and Ellis-Stoll, C.C. (2008) Postoperative surgical chest and leg incision sites using platelet gel: A retrospective study. The Journal of Extra- Corporeal Technology, 40, 225-228.
 Hom, D.B., Linzie, B.M. and Huang, T.C. (2007) The healing effects of autologous platelet gel on acute human skin wounds. Archives of Facial Plastic Surgery: Official Publication for the American Academy of Facial Plastic and Reconstructive Surgery, Inc. and the International Federation of Facial Plastic Surgery Societies, 9, 174- 183. doi:10.1001/archfaci.9.3.174
 Zavadil, D.P., Satterlee, C.C., Costigan, J.M., Holt, D.W., Shostrom and V.K. (2007) Autologous platelet gel and platelet-poor plasma reduce pain with total shoulder ar- throplasty. The Journal of Extra-Corporeal Technology, 39, 177-182.