IJOC  Vol.2 No.4 , December 2012
Synthesis and Biological Evaluation of Novel 6-(3-(4,5-Dihydro-1,5-diphenyl-1H-pyrazol-3-yl)phenylamino) Pyridazin-3(2H)-one Derivatives
Abstract: Pyrazoles are important nitrogen containing 5-membered heterocyclic compounds. Numerous pyrazoline derivatives have been found to possess considerable biological activities, which stimulated the research activity in this field. Several 1,3,5-Triphenyl-1H-pyrazole containing 6-aminopyridazin-3(2H)-one derivatives has been synthesized. These new compounds were characterized using IR, 1H-NMR and Mass spectra and Elemental analysis. They possess some potent biological activities. Therefore biological screening of novel compounds has been also done.
Cite this paper: S. Tupare, S. Dake, S. Nalage, S. Bhosale, R. Ingle and R. Pawar, "Synthesis and Biological Evaluation of Novel 6-(3-(4,5-Dihydro-1,5-diphenyl-1H-pyrazol-3-yl)phenylamino) Pyridazin-3(2H)-one Derivatives," International Journal of Organic Chemistry, Vol. 2 No. 4, 2012, pp. 371-376. doi: 10.4236/ijoc.2012.24051.

[1]   J. F. Swinbourne, H. J. Hunt and G. Klinkert, “An Efficient One Pot Synthesis of 4H-Pyrrolo[3,2,ij]quinolines,” Advances in Heterocyclic Chemistry, Vol. 23, 1987, pp. 103-170. doi:10.1016/S0065-2725(08)60842-9

[2]   J. V. Greenhill, “In Comprehensive Heterocyclic Chemistry,” A. R. Katritzky and C. W. Rees, Eds., Pergamon Press, London, Vol. 5, 1984, p. 302.

[3]   J. Elguero, “Evaluation of Antidepressant Effect of 2- Pyrazoline Derivatives,” In: A. R. Katritzky and C. W. Rees, Eds., Comprehensive Heterocyclic Chemistry, Pergamon Press, London, Vol. 3, 1996, p. 1.

[4]   D. Nauduri and G. B. Reddy, “Synthesis and Activity of 2-Pyrazoline Derivatives,” Chemical & Pharmaceutical Bulletin, Tokyo, Vol. 46, 1998, pp. 1254-1260. doi:10.1248/cpb.46.1254

[5]   S. S. Korgaokar, P. H. Patil, M. T. Shah and H. H. Parekh, Studies on Pyrazolines: Preparation and Antimicrobial Activity of 3-(3’(p-chlorophenylsulphonamidophenyl)-5-aryl-acetylpyrazolines,” Indian Journal of Pharmaceutical Sciences, Vol. 58, No. 6, 1996, pp. 222-225.

[6]   R. H. Udupi, A. R. Kushnoor and A. R Bhat, “Synthesis and Biological Evaluation of Certain Pyrazoline Derivative of 2-(6-methoxynaphthyl)-propionic Acid,” Indian Journal of Heterocyclic Chemistry, Vol. 8, No. 1, 1998, pp. 63-66.

[7]   A. A. Bilgin, E. Palaska and R. Sunal, “Arzeimforsch; Evaluation of Antidepressant Effect of Pyrazoline Derivatives,” Drug Research, Vol. 43, 1993, pp. 1041-1044.

[8]   D. Azarifer and H. Ghasemnejad, “Microwave-Assisted Synthesis of Some 3,5-Arylated 2-Pyrazolines,” Molecules, Vol. 8, No. 8, 2003, pp. 642-648. doi:10.3390/80800642

[9]   D. Azarifer and M. Shaebanzadeh, “Synthesis and Characterization of New 3,5-Dinaphthyl Substituted 2-Pyrazolines and Study of Their Antimicrobial Activity,” Molecules, Vol. 7, No. 12, 2002, pp. 885-895. doi:10.3390/71200885

[10]   M. A. Ali, A. A. Siddiqui and M. S. Synthesis, “Structural Activity Relationship and Anti-Tubercular Activity of Novel Pyrazolines Derivatives,” European Journal of Medicinal Chemistry, Vol. 42, No. 2, 2007, pp. 268-275. doi:10.1016/j.ejmech.2006.08.004

[11]   M. Amir, H. Kumar and S. A. Khan, “Synthesis and Pharmacological Evaluation of Pyrazoline Derivatives as New Anti-Inflammatory and Analgesic Agents,” Bioorganic & Medicinal Chemistry Letters, Vol. 18, No. 3, 2008, pp. 918-922. doi:10.1016/j.bmcl.2007.12.043

[12]   L. Knorr, “Notiz uber die Pyrazolinreaction,” Berichte der Deutschen Chemischen Gesellschaft, Vol. 26, No. 1, 1893, pp. 100-103. doi:10.1002/cber.18930260123

[13]   V. Malhotra, S. Pathak, R. Nath, D. Mukerjee and K. Shankar, “Substituted Imidazole Derivatives as Novel Cardiovascular Agents,” Indian Journal of Chemistry, Vol. 41B, 2002, p. 1310.

[14]   T. L. Ji, H. Z. Xiao and P. L. B. Zhi, “An Improved Synthesis of 1,3,5-Triaryl-2-pyrazolines in Acetic Acid Aqueous Solution under Ultrasound Irradiation,” The Journal of Organic Chemistry, Vol. 3, No. 1, 2007, p. 13-16.

[15]   A. Levai, “Synthesis of Chlorinated 3,5-Diaryl-2-pyrazolines by the Reaction of Chlorochalcones with Hydrazines,” Arkivoc, 2005, pp. 344-352.

[16]   R. J. Grayer and J. B. Harborne, “A Survey of Antifungal Compounds from Higher Plants,” Phytochemistry, Vol. 37, No. 1, 1994, pp. 19-42. doi:10.1016/0031-9422(94)85005-4

[17]   O. N. Irob, M. Moo-Young and W. A. Anderson, “Antimicrobial Activity of Annatto Extract,” International Journal of Pharmaceutics, Vol. 34, No. 2, 1996, pp. 87-90. doi:10.1076/phbi.