JCDSA  Vol.2 No.4 , December 2012
Concomitant Occurrence of Segmental Neurofibromatosis and Lung Adenocarcinoma
Abstract
Neurofibromatosis type 1 (NF1) caused by a loss-of functional mutation in NF1 encoding neurofibromin is an autosomal dominant disorder characterized by café-au-lait spots, neurofibromas, intertriginous freckles, and Lisch nodules. Segmental neurofibromatosis (SN) represents a postzygotic mutation and loss of heterozygosity in neurofibromin. SN occurring in the elder persons may be associated with internal malignant tumors. Here, we reported a case of 58-year-old woman with concomitant occurrence of SN and lung adenocarcinoma. The onset of SN in aged persons would be a sign of concomitant occurrence of internal malignant tumors.

Cite this paper
R. Morita, N. Oiso and A. Kawada, "Concomitant Occurrence of Segmental Neurofibromatosis and Lung Adenocarcinoma," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 4, 2012, pp. 265-266. doi: 10.4236/jcdsa.2012.24050.
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