Martine K. F. Docx^*, Annik Simons, José Ramet, Luc Mertens, Paul Govaert

Show more
Department of Paediatrics, Queen Paola Children’s Hospital, Antwerp, Belgium.
Department of Child Psychiatry, Queen Paola Children’s Hospital, Belgium and University of Antwerp, Antwerp, Belgium.
Department of Paediatrics, University Hospital, Antwerp, Belgium.
Division of Cardiology, The Hospital for Sick Children, Toronto, Canada.
Show less

Abstract: This is a 12th case report on olanzapine induced hypothermia and based on the results of literature search, by far is the youngest case ever is reported. The hypothermia occurred during the refeeding phase, despite a weight gain since increasing the dosage from 5 mg to 7.5 mg olanzapine. Our recent literature search found 11 published cases of olanzapine treatment associated with hypothermia. Olanzapine acts on serotonin or dopamin receptors and has antagonistic properties on histaminergic, muscarinic and α-adrenergic receptors. Olanzapine mediates the hypothermic effect through antagonism at receptors other than dopamine.

Keywords: Anorexia Nervosa; Olanzapine; Hypothermia

Cite this paper: Docx, M. , Simons, A. , Ramet, J. , Mertens, L. and Govaert, P. (2012) Olanzapine-associated hypothermia in an adolescent anorexic girl. Open Journal of Clinical Diagnostics, 2, 76-80. doi: 10.4236/ojcd.2012.24017.

References

[1]   Bymaster, F.P., Hemrick-Luecke, S.K., Perry, K.W. and Fuller, R.W. (1996) Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, α1-adrenergic and muscarinic, receptors in vivo in rats. Psychopharmacology, 124, 87-94. doi:10.1007/BF02245608

[2]   Bymaster, F.P., Nelson, D.L., DeLapp, N.W., Falcone, J.F., Eckols, K., Truex, L.L., Foreman, M.M., Lucaites, V.L. and Calligaro, D.O. (1999) Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and α1-adrenergic receptors in vitro. Schizophrenia Research, 37, 107-122. doi:10.1016/S0920-9964(98)00146-7

[3]   Razaq, M. and Samma, M. (2004) A case of risperdone-induced hypothermia. American Journal of Therapeutics, 11, 229-230. doi:10.1097/00045391-200405000-00012

[4]   Danzl, D. (2002) Hypothermia. Seminars in Respiratory and Critical Care Medicine, 23, 57-68. doi:10.1055/s-2002-20589

[5]   Blass, D.M. and Chuen, M. (2004) Olanzapine-associated hypothermia. Psychosomatics, 45, 135-139. doi:10.1176/appi.psy.45.2.135

[6]   H?gg, S., Mj?rndal, T. and Lindqvist, L. (2001) Repeated episodes of hypothermia in a subject treated with haloperidol, levomepromazine, olanzapine, and thioridazine. Journal of Clinical Psychopharmacology, 21, 113-115. doi:10.1097/00004714-200102000-00023

[7]   Kreuzer, P., Landgrebe, M., Hajak, G., Burger, S.J. and Langguth, B. (2011) A case of severe hypothermia following single-dose administration of olanzapine: A case report. Journal of Clinical Psychopharmacology, February, 22.

[8]   Kreuzer, P., Landgrebe, M., Wittmann, M., Hajak, G., Schencklmann, M., Poeppl, T.B. and Langguth, B. (2011) Hypothermia under olanzepine treatment: Clinical case series and review of current literature. Der Nervenarzt, 83, 630-637. doi:10.1007/s00115-011-3310-y

[9]   Rasnayake, L.R., Wimalarathne, H., Jayapala, R.K., Gamage, C.D., Dassanayake, D.L., Ratnayake, S.L., Colombage, A., Nandadeva, D. and Nelumdeniya, A.N. (2011) An usual case of hypothermia associated with therapeutic doses of olanzapine: A case report. Journal of Medical Case Reports, 18, 189.

[10]   Norris, M.L., Spettigue, W., Buchhol, A., Henderson, K.A., Gomez, R., Maras, D., Gaboury, I. and Ni, A. (2011) Olanzapine use for the adjunctive treatment of adolescents with anorexia nervosa. Journal of Child and Adolescent Psychopharmacology, 21, 213-220. doi:10.1089/cap.2010.0131

[11]   Hein, I.M. and Huyser, C. (2010) Olanzepine in de behandeling van adolescenten met anorexia nervosa. Tijdschrift voor Psychiatrie, 52, 417-421.

[12]   Phan, T.G., Yu, R.Y. and Hersch, M. (1998) Hypothermia induced by risperdone and olanzapine in a patient with Prader-Willi syndrome. Medical Journal of Australia, 169, 230-231.

[13]   Parris, C., Mack, J.M., Cochiolo, J.A., Steinmann, A.F. and Tietjen, J. (2001) Hypothermia in 2 patients treated with atypical antipsychotic medication. Journal of Clinical Psychopharmacology, 62, 61-63. doi:10.4088/JCP.v62n0112g

[14]   Fukunishi, I., Sato, Y., Kino, K., Shirai, T. and Kitaoka, T. (2003) Hypothermia in a hemodialysis patient treated with olanzepine monotherapy. Journal of Clinical Psychopharmacology, 23, 314. doi:10.1097/00004714-200306000-00013

[15]   Lee, T.W., Tsai, S.J. and Hwang, J.P. (2003) Severe cardiovascular side effects of olanzapine in an eldery patient: Case report. The International Journal of Psychiatry in Medicine, 33, 399-401. doi:10.2190/U99G-XDML-0GRG-BYE0

[16]   Hung, C.F., Huang, T.Y. and Lin, P.Y. (2009) Hypothermia and rhabdomyolysis following olanzapine injection in an adolescent with schizophreniform disorder. General Hospital Psychiatry, 31, 376-378. doi:10.1016/j.genhosppsych.2008.09.009

[17]   Mu?oz, M.T. and Argente, J. (2002) Anorexia nervosa in female adolescents: Endocrine and bone mineral density disturbances. European Journal of Endocrinology, 147, 275-286. doi:10.1530/eje.0.1470275

[18]   Oerther, S. and Ahlenius, S. (2000) Atypical antipsychotics and dopamine D(1) receptor agonism: An in vivo experimental study using core temperature measurements in the rat. Journal of Pharmacology and Experimental Therapeutics, 29, 731-736.