OJPed  Vol.2 No.4 , December 2012
Safety and efficacy of Dai-kenchu-to in postoperative infants with gastroschisis
ABSTRACT
Purpose: Intestinal dysfunction is a major problem after gastroschisis repair, and causes poor oral intake and poor body weight gain in infants with gastroschisis. Dai-kenchu-to (DKT) is often used in the treatment of gastrointestinal dysfunction in Japan. The purpose of this study was to analyze the effect of DKT on infants with uncomplicated gastroschisis. Methods: In this retrospective cohort study from 1991 to 2009, we assessed 16 infants with uncomplicated gastroschisis. Eight infants received 0.3 g/kg/day of DKT for 12 months (group 1) and 8 infants did not receive DKT (group 2). We analyzed their body weight as an indicator of the effect of DKT. Results: There were no significant differences in the background characteristics. The body weight of group 1 was significantly increased at the ages of 9 months (p = 0.0348) and 12 months (p = 0.0097), compared with group 2. Multivariate analyses revealed that only DKT administration had a significant impact on body weight gain at the ages of 9 months (p = 0.0201) and 12 months (p = 0.0111). No side effects related to DKT were reported. Conclusion: DKT administration might work safely and effectively for improving the body weight gain in infants with uncomplicated gastroschisis.

Cite this paper
Otake, K. , Uchida, K. , Koike, Y. , Inoue, M. , Matsushita, K. , Hashimoto, K. , Ide, S. , Nagano, Y. and Kusunoki, M. (2012) Safety and efficacy of Dai-kenchu-to in postoperative infants with gastroschisis. Open Journal of Pediatrics, 2, 272-277. doi: 10.4236/ojped.2012.24045.
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