IJOC  Vol.2 No.3 A , November 2012
Quantitative Determination of Click Reaction in the Presence of Glycine Derivatives and in Dilute Solution
ABSTRACT
The click reaction is one of the latest techniques for the functional analysis of bioactive compounds and the analysis makes novel concepts and strategies for medicinal chemistry. N-methylated glycine derivatives have inhibitory activity for the click reaction in direct Cu(I) system because of decrease of Cu(I) concentration. The Cu(I) concentration recovered effectively by sodium ascorbate. Quantitative determination of click reaction at various ligand concentrations revealed that the decrease in reaction yields was observed in a substrate concentration-dependent manner.

Cite this paper
Y. Ogasawara, Y. Murai, Y. Sakihama, Y. Hashidoko and M. Hashimoto, "Quantitative Determination of Click Reaction in the Presence of Glycine Derivatives and in Dilute Solution," International Journal of Organic Chemistry, Vol. 2 No. 3, 2012, pp. 302-304. doi: 10.4236/ijoc.2012.223041.
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