Health  Vol.2 No.8 , August 2010
A possible association between cervical erosion in pregnant women and congenital abnormalities in their children-a population-based case-control study
ABSTRACT
Objective to study the possible association between erosion of cervix in pregnant women (ECP) and structural birth defects, i.e. congenital abnormalities (CA) in their offspring. Study design: Comparison of cases with CA and all matched controls without any CA born to wo- men with prospectively and medical record ECP in the population-based large data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA). Results: HCC- SCA contained 22,843 cases and 38,151 matched controls, the informative offspring of 40 (0.18%) case mothers and the newborns of 25 control mothers (0.07%) with ECP were compared and the higher risk for total CA (adjusted OR with 95% CI: 2.7, 1.6-4.4) was found explained by the higher risk of 9 cases with hypospadias (OR with 95% CI: 4.5, 2.1-9.7) and 10 cases with car-diovascular CAs (OR with 95% CI: 3.4, 1.6-7.1), particularly with conotruncal CAs. Conclusions: An unexpected possible association of ECP with higher risk for hypospadias and conotrun-cal cardiovascular CAs was found and these findings are considered as signals that need confirmation or rejection

Cite this paper
nullBánhidy, F. , Ács, N. , Puhó, E. and Czeizel, A. (2010) A possible association between cervical erosion in pregnant women and congenital abnormalities in their children-a population-based case-control study. Health, 2, 945-950. doi: 10.4236/health.2010.28140.
References
[1]   Czeizel, A.E., ács, N., Bánhidy, F. and Vogt, G. (2006) Possible association between maternal diseases during pregnancy and congenital abnormalities. In: Engels, J.V., Ed. Birth defects: New research. NOVA Science Pub-lisher, New York, 55-70.

[2]   Gabbe, S.G., Niebyl, J.R. and Simpson, J.L. (2001) Ob-stetrics: Normal and problem pregnancies. 4th Edition, Churchill Livingstone, New York.

[3]   Shepard, T.H. and Lemire, R.J. (2004) Catalog of Tera-togenic Agents, 11th Edition. Johns Hopkins University Press, Baltimore.

[4]   Czeizel, A.E., Rockenbauer, M., Siffel, C. and Varga, E. (2001) Description and mission evaluation of the hun-garian case-control surveillance of congenital abnormali-ties, 1980-1996. Teratology, 63(5), 176-185.

[5]   Czeizel, A.E. (1997) First 25 years of the hungarian con-genital abnormality registry. Teratology, 55(5), 299-305.

[6]   Czeizel, A.E., Petik, D. and Vargha, P. (2003) Validation studies of drug exposures in pregnant women. Pharma-coepid Drug Safety, 12(5), 409-416.

[7]   Czeizel, A.E. and Vargha, P. (2004) Periconceptional folic acid/multivitamin supplementation and twin pre- gnancy. American Journal of Obstetrics and Gynecology, 191(3), 790-794.

[8]   WHO. (2007) International classification of disease. 10th revision, Wold Health Organization, Geneva.

[9]   Puho, E., Métneki, J. and Czeizel, A.E. (2005) Maternal employment status and isolated orofacial clefts in Hungary. Central European Journal of Public Health, 13(3), 144-148.

[10]   Adams, F.H., Emmanouilideas, G.C. and Riemenschnei-der, T.A. (1989) Heart disease in infants, children and adolescents. Williams and Wilkins, Baltimore.

[11]   ács, F., Bánhidy, F., Puho, H.E. and Czeizel, A.E. (2008) Possible association between acute pelvic inflammatory disease in pregnant women and congenital abnormalities in their offspring? A population-based case-control study. Birth Defects Research (Part A), 82(8), 563-570.

[12]   Sharpe, R.M. and Skakkeback, N.E. (1993) Are oestro-gens involved in falling sperm counts and disorders of the male reproductive tract? Lancet, 341(8857), 1392- 1395.

[13]   Kim, K.S., Torres, C.R. Jr, Yucel, S., et al. (2004) Induc-tion of hypospadis in a murine model by maternal expo-sure to synthetic estrogens. Environmental Research, 94, 267-275.

[14]   Janerich, D.T., Dugan, J.M., Standfast, S.J. and Strite, L. (1977) Congenital heart disease and prenatal exposure to exogenous sex hormeones. British Medical Journal, 1(6068), 1058-1060.

[15]   Bracken, M.B. (1990) Oral contraception and congenital malformations in offspring: A review and meta-analysis of the prospective studies. Obstetrics & Gynecology, 76(3), 552-557.

[16]   Czeizel, A.E. (2009) The estimation of human terato-genic/fetotoxic risk of exposures to drugs on the basis of Hungarian experience: a critical evaluation of clinical and epidemiological models of human teratology. Expert Opinion on Drug Safety, 8(3), 283-303.

[17]   Czeizel, A.E., Er?s, E., Rockenbauer, M., S?rensen, H.T. and Olsen, J. (2003) Shortterm oral diazepam treatment during pregnancy—A population-based teratological case-control study. Clinical Drug Investigation, 23, 451- 462.

[18]   Bártfai, Z., Kocsis, J., Puhó, H.E. and Czeizel, A.E. (2008) A population-based case-control study of pro- methazine use during pregnancy. Reproductive Toxicol-ogy, 25(2), 276-285.

[19]   Gidai, J., ács, N., Bánhidy, F. and Czeizel, A.E. (2008) No association found between use of very large doses of diazepam by 112 pregnant women for a suicide attempt and congenital abnormalities in their offspring. Toxic In-dust Health, 24, 29-39.

[20]   Petik, D., ács, N., Bánhidy, F. and Czeizel, A.E. (2008) A study of the potential teratogenic effects of large doses of promethazine in 32 self-poisoned pregnant women. Toxic Indust Health, 24(1-2), 87-96.

[21]   Czeizel, A.E. and Huiskes, N. (1988) A case-control study to evaluate the risk of congenital anomalies as a result of allylestrenol therapy during pregnancy. Clinical Therapeutics, 10, 725-739.

 
 
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