IJCM  Vol.3 No.6 , November 2012
Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report
ABSTRACT
Pharmacological treatment of narcolepsy is complex. We reported a case of recurrent episodes of polymorphic ventricular tachycardia attributed to the use of modafinil, a recently approved wake-promoting agent for narcolepsy and shift work sleep disorder. Modafinil is also approved as adjunctive treatment of obstructive sleep apnea/hypopnea syndrome. While the exact mechanism of action for modafinil is not known, central dopamine receptors seem to play an essential role. Adverse influences on the electrocardiogram (ECG) or drug-related cardiac arrhythmias are rarely reported, but are considered as clinically important.

Cite this paper
H. Binnenmars, H. Idzerda, H. Tan and G. Linssen, "Ventricular Tachycardia during Treatment with Modafinil for Narcolepsy: A Case Report," International Journal of Clinical Medicine, Vol. 3 No. 6, 2012, pp. 513-517. doi: 10.4236/ijcm.2012.36092.
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