OJOG  Vol.2 No.4 , November 2012
Striae gravidarum as a predictor of spontaneous preterm delivery: A case control study
Abstract: Background/Aims: The association between striae gravidarum (SG) and preterm delivery may be postulated because of sharing similar poor organization of extracellular matrix in both skin and cervix. Our goal was to compare the frequency of striae gravidarum in women who gave preterm birth and women who gave term birth. Methods: A case-control study was conducted in women who gave preterm birth (n = 66) and age matched women who gave term birth (n = 68). Cases and controls were recruited from puerperal women consequently seen at delivery wards of perinatology unit. All women underwent dermatologic examination in terms of SG blindly to theirs gestational weeks of delivery. The frequency of SG was compared in all groups. Results: The frequency of SG was 63.6% in women with preterm birth and 54.4% in women with term birth (p = 0.278). SG is five times more common in late preterm group than in women with term group, but this difference was not statistically significant [(p = 0.227, OR: 5.02, CI 95% (0.5 - 44.0)]. The rate of preventive cream usage was not statistically different in women with SG and without SG (p = 0.245). Conclusions: It seems that there was no statistically significant association between the risk of preterm labor and the presence of striae gravidarum. Larger prospective observational studies are needed to state expressly the probable clinical association between the presence of SG and preterm delivery.
Cite this paper: Kelekci, S. , Gencdal, S. , Ozdemir, O. , Destegul, E. and Handan Kelekci, K. (2012) Striae gravidarum as a predictor of spontaneous preterm delivery: A case control study. Open Journal of Obstetrics and Gynecology, 2, 394-397. doi: 10.4236/ojog.2012.24081.

[1]   Lawn, J.E., Cousens, S. and Zupan, J. (2005) 4 million neonatal deaths. When? Where? Why? Lancet, 365, 891-900. doi:10.1016/S0140-6736(05)71048-5

[2]   Goldenberg, R.L., Culhane, J.F., Iams, J.D. and Romero, R. (2008) Epidemiology and causes of preterm birth. Lancet, 371, 75-84. doi:10.1016/S0140-6736(08)60074-4

[3]   Viennet, C., Bride, J., Cohen-Letessier, A. and Humbert, P. (2001) Mechanical behavior of fibroblasts included in collagen lattices. Journal de la Société de Biologie, 195, 427-433.

[4]   Burrows, N.P. and Lovell, C.R. (2004) Disorders of connective tissue. In: Burns, T., Breathnach, S., Cox, N., Griffith, C., Eds., Rook’s Textbook of Dermatology, 7th Edition, Blackwell Science, Oxford, 46-47. doi:10.1002/9780470750520.ch46

[5]   Watson, R.E., Parry, E.J. and Humphries, J.D. (1998) Fibrillin microfibrils are reduced in skin exhibiting striae distensae. British Journal of Dermatology, 138, 931-937. doi:10.1046/j.1365-2133.1998.02257.x

[6]   Lee, K.S., Rho, Y.J. and Jang, S.I. (1994) Decreased expression of collagen and fibronectin genes in striae distensae tissue. Clinical and Experimental Dermatology, 19, 285-288. doi:10.1111/j.1365-2230.1994.tb01196.x

[7]   Kelekci, K.H., Kelekci, S., Destegul, E., Aksoy, A., Sut, N. and Yilmaz, B. (2011) Prematurity: Is it a risk factor for striae distensae? International Journal of Dermatology, 50, 1240-1245. doi:10.1111/j.1365-4632.2011.04899.x

[8]   Schuster, S. (1979) The cause of striae distensae. Acta Dermato-Venereologica, 59, 161-169.

[9]   Chang, A.L., Agredana, X.Z. and Kimball, A.B. (2004) Risk factors associated with striae gravidarum. Journal of the American Academy of Dermatology, 51, 881-885. doi:10.1016/j.jaad.2004.05.030

[10]   Atwal, G.S., Manku, L.K., Griffiths, C.E. and Palson, D.W. (2006) Striae gravidarum in primiparae. British Journal of Dermatology, 155, 965-969. doi:10.1111/j.1365-2133.2006.07427.x

[11]   Thomas, R.G. and Liston, W.A. (2004) Clinical associations of striae gravidarum. Journal of Obstetrics & Gynaecology, 24, 270-271. doi:10.1080/014436104101001660779

[12]   J-Orh, R., Titapant, V., Chwennattana, P. and Tontisirin, P. (2008) Prevalence and associate factors for striae gravidarum. Journal of the Medical Association of Thailand, 91, 445-451.

[13]   Osman, H., Rubeiz, N., Tamim, H. and Nassar, A.H. (2007) Risk factors for the development of striae gravidarum. American Journal of Obstetrics & Gynecology, 196, 62.e1-62.e4

[14]   Salter, S.A., Batra, R.S. and Rohrer, T.E. (2006) Striae and pelvic relaxation: two disorders of connective tissue with strong association, Journal of Investigative Dermatology, 126, 1475-1478. doi:10.1038/sj.jid.5700258

[15]   Smith, L.K., Draper, E.S., Manktelow, B.N., Dorling, J.S. and Field, D.J. (2007) Socioeconomic inequalities in very preterm birth rates. Archives of Disease in Childhood. Fetal and Neonatal Edition, 92, 11-14. doi:10.1136/adc.2005.090308

[16]   Wierrani, F., Kozak, W., Schramm, W. and Grunberger, W. (1992) Attempt of preventive treatment of striae gravidarum using preventive massage ointment administration [in German]. Wiener Klinische Wochenschrift, 104, 42-44.

[17]   Madlon-Kay, D.J. (1993) Striae gravidarum. Folklore and fact. Archives of Family Medicine, 2, 507-511. doi:10.1001/archfami.2.5.507

[18]   Buchanan, K., Fletcher, H.M. and Reid, M. (2010) Prevention of striae gravidarum with cocoa butter cream. International Journal of Gynecology & Obstetrics, 108, 65-68.