Back
 OJEMD  Vol.2 No.4 , November 2012
Autoimmune Thyroid, Celiac and Addison’s Diseases Related to HLA-DQ Types in Young Patients with Type 1 Diabetes in Belgium
Abstract: Objective: To define the prevalence of auto antibodies (Ab) to different organs in young patients with type 1 diabetes (type 1DM). Methods: Ab to thyroid, celiac and adrenal disease was analyzed in 831 type 1 DM patients. Results: Hundred twenty-three (14.8%) had positive thyroid Ab. The risk of developing thyroid Ab was increased in girls (HR 2.3; 95% CI 1.6 - 3.2, p < 0.0001). Thirty-three (3.9%) patients had positive endomysium Ab (3.1% in girls and 3.5% in boys, p = NS). Adrenal Ab was detected in 5 patients. The DQA1*0301-DQB1*0301 haplotype was more prevalent in patients with thyroid Ab (p = 0.0281); DQA1*301-DQB1*302 and DQA1*501-DQB1*201 in patients with endo- mysium Ab (p = 0.0251 and p < 0.0001). All patients with adrenal Ab were DQA1*301-DQB1*302 positive. Conclusions: Type 1D patients should be screened annually for thyroid autoimmunity and celiac disease. The DQA1*0301-DQB1*0301 haplotype seems to confer susceptibility to thyroid autoimmunity, DQA1*301-DQB1*302 and DQA1*501-DQB1*201 to celiac disease and DQA1*301-DQB1*302 to adrenal autoimmunity.
Cite this paper: A. Messaaoui, S. Tenoutasse, B. Van der Auwera, C. Mélot and H. Dorchy, "Autoimmune Thyroid, Celiac and Addison’s Diseases Related to HLA-DQ Types in Young Patients with Type 1 Diabetes in Belgium," Open Journal of Endocrine and Metabolic Diseases, Vol. 2 No. 4, 2012, pp. 70-73. doi: 10.4236/ojemd.2012.24011.
References

[1]   J. A. Todd, “Etiology of Type 1 Diabetes,” Immunity, Vol. 32, No. 4, 2010, pp. 457-467. doi:10.1016/j.immuni.2010.04.001

[2]   H. Dorchy, B. Lemiere, D. Toussaint and P. Gausset, “Islet-Cell Antibodies and Organ-Specific Antibodies in Diabetic Children and Adolescents,” Nouvelle Presse Médicale, Vol. 10, No. 34, 1981, pp. 2795-2798.

[3]   T. M. Triolo, T. K. Armstrong, K. McFann, L. Yu, M. J. Rewers, G. J. Klingensmith, G. S. Eisenbarth and J. M. Barker, “Additional Autoimmune Disease Found in 33% of Patients at Type 1 Diabetes Onset,” Diabetes Care, Vol. 34, No. 5, 2011, pp. 1211-1213. doi:10.2337/dc10-1756

[4]   J. M. Barker, “Clinical Review: Type 1 Diabetes-Associated Autoimmunity: Natural History, Genetic Associations and Screening,” The Journal of Clinical Endocrinology & Metabolism, Vol. 91, No. 4, 2006, pp. 1210-1217. doi:10.1210/jc.2005-1679

[5]   A. G. Ziegler and G. T. Nepom, “Prediction and Pathogenesis in Type 1 Diabetes,” Immunity, Vol. 32, No. 4, 2010, pp. 468-478. doi:10.1016/j.immuni.2010.03.018

[6]   H. Heimberg, Z. P. Nagy, G. Somers, I. De Leeuw and F. C. Schuit, “Complementation of HLA DQA and -DQB Genes Confers Susceptibility and Protection to Insulin-Dependent Diabetes Mellitus,” Human Immunology, Vol. 33, No. 1, 1992, pp. 10-11. doi:10.1016/0198-8859(92)90046-P

[7]   J. M. Barker, J. Yu, L. Yu, J. Wang, D. Miao, F. Bao, E. Hoffenberg, J. C. Nelson , P. A. Gottlieb, M. Rewers and G. S. Eisenbarth, “Autoantibody ‘Subspecificity’ in Type 1 Diabetes,” Diabetes Care, Vol. 28, No. 4, 2005, pp. 850-855. doi:10.2337/diacare.28.4.850

[8]   S. Sud, M. Marcon, E. Assor, D. Daneman and F. H. Mahmud, “Quality of Life in Children with Diabetes and Celiac Disease: Minimal Impact of the ‘Double Diagnosis’,” Pediatric Diabetes, Vol. 13, No. 2, 2012, pp. 163-169. doi:10.1111/j.1399-5448.2011.00785.x

[9]   E. Piatkowska and M. Szalecki, “Autoimmune Thyroiditis in Children and Adolescents with Type 1 Diabtetes”, Pediatric Endocrinology, Diabetes, and Metabolism, Vol. 17, No. 4, 2011, pp. 173-177.

[10]   O. Kordonouri, A. Klinghammer, E. B. Lang, A. Gruters-Kieslich, M. Grabert and R. W. Holl, “Thyroid Autoimmunity in Children and Adolescents with Type 1 Diabetes,” Diabetes Care, Vol. 25, No. 8, 2002, pp. 1346-1350. doi:10.2337/diacare.25.8.1346

 
 
Top