OJRD  Vol.2 No.4 , November 2012
Do Circulating RSV-Genotypes Affect Established Biennial Epidemic Periodicity in Zagreb Region?
ABSTRACT
Objective: The biennial epidemic pattern of respiratory syncytial virus (RSV) circulation in Croatia has been preserved and could not be related to climatic factors and the predominant RSV subtypes. The possibility that the circulation of different RSV genotypes affect the outbreak cycle in children in Croatia (Zagreb region) over a period of 3 consecutive years was explored in the paper. Methods: The study group consisted of inpatients, aged 0-10 years, who were hospi- talized with acute respiratory tract infections caused by RSV, in Zagreb, over the period from 1 January 2006 to 31 De- cember 2008. The virus was identified in the nasopharyngeal secretion using direct immunofluorescence method. The virus subtype and genotype was determined by real-time PCR and sequence analysis, respectively. Results: RSV infec- tions identified in 731 children. RSV subtype A caused 399 infections, and subtype B 332. Two subtype A genotypes (NA1 and GA5) and three subtype B genotypes (BA7, BA9 and BA10) were found. During persistent RSV biennial cycles namely four succeeding outbreaks, the new genotype from the previous smaller outbreak persevered into the up- coming larger outbreak. Conclusion: Our molecular-epidemiology study of RSV subtypes and genotypes during calen- dar months demonstrates that the biennial RSV cycle cannot be fully explained by the dynamic of the predominant cir- culating genotype of RSV. Other unknown factors account for the biennial cycle of RSV epidemics in Croatia.).

Cite this paper
G. Mlinaric-Galinovic, D. Forcic, J. Ivancic-Jelecki, G. Vojnovic, J. Bozikov and R. Welliver, "Do Circulating RSV-Genotypes Affect Established Biennial Epidemic Periodicity in Zagreb Region?," Open Journal of Respiratory Diseases, Vol. 2 No. 4, 2012, pp. 91-94. doi: 10.4236/ojrd.2012.24013.
References
[1]   G. Mlinaric-Galinovic, et al., “The Biennial Cycle of Respiratory Syncytial Virus Outbreaks in Croatia,” Virology Journal, Vol. 5, No. 1, 2008, pp. 18-22. doi:10.1186/1743-422X-5-18

[2]   G. Mlinaric-Galinovic, et al., “Does the Viral Subtype Influence the Biennial Cycle of Respiratory Syncytial Virus?” Virology Journal, Vol. 6, No. 1, 2009, pp. 133-139. doi:10.1186/1743-422X-6-133

[3]   E. Terletskaia-Ladwig, et al., “Defining the Timing of Respiratory Syncytial Virus (RSV) Outbreaks: An Epidemiological Study,” BMC Infectious Diseases, Vol. 5, 2005, No. 1, pp. 20-27. doi:10.1186/1471-2334-5-20

[4]   R. Berner, et al., “Community and Nosocomially Acquired Respiratory Syncytial Virus Infection in a German Paediatric Hospital from 1988 to 1999,” European Journal of Pediatrics, Vol. 160, No. 9, 2001, pp. 541-547. doi:10.1007/s004310100801

[5]   A. Duppenthaler, et al., “Two-Year Periodicity of Respiratory Syncytial Virus Epidemicsin Switzerland,” Infection, Vol. 31, No. 2, 2003, pp. 75-80. doi:10.1007/s15010-002-3124-8

[6]   S. W. Aberle, et al., “Biennial Spring Activity of Human Metapneumovirus in Austria,” Pediatric Infectious Disease Journal, Vol. 27, No. 12, 2008, pp. 1065-1068. doi:10.1097/INF.0b013e31817ef4fd

[7]   G. Mlinaric-Galinovic, et al., “Eleven Consecutive Years of Respiratory Syncytial Virus Outbreaks in Croatia,” Pediatrics International, Vol. 51, No. 2, 2009, pp. 237-240. doi:10.1111/j.1442-200X.2008.02723.x

[8]   G. Mlinaric-Galinovic, et al., “Znacajke Javljanja Epidemije Respiratornim Sincicijskim Virusom U Sezoni 2006/7 U Zagreba?koj ?upaniji,” Paediatria Croatica, Vol. 53, No. 2, 2009, pp. 49-52.

[9]   G. Mlinaric-Galinovic et al., “Analysis of Biennial Outbreak Pattern of Respiratory Syncytial Virus According To Subtype (A and B) in the Zagreb Region,” Pediatrics International, Vol. 54, No. 3, 2012, pp. 331-335. doi:10.1111/j.1442-200X.2011.03557.x

[10]   K. T. Zlateva, et al., “Subgroup Prevalence and Genotype Circulation Patterns of Human Respiratory Syncytial Virus in Belgium during Ten Successive Epidemic Seasons,” Journal of Clinical Microbiology, Vol. 45, No. 9, 2007, pp. 3022-3030. doi:10.1128/JCM.00339-07

[11]   Y. Shobugawa, et al., “Emerging Genotypes of Human Respiratory Syncytial Virus Subgroup A among Patients in Japan,” Journal of Clinical Microbiology, Vol. 47, No. 8, 2009, pp. 2475-2482. doi:10.1128/JCM.00115-09

[12]   D. Forcic, et al., “A Study of the Genetic Variability of Human Respiratory Syncytial Virus in Croatia, 20062008,” Journal of Medical Virology, Vol. 84, No. 12, 2012, pp. 1985-1992.

[13]   N. L. Goddard, et al., “Timing of Monoclonal Antibody for Seasonal RSV Prophylaxis in the United Kingdom,” Epidemiology and Infection, Vol. 135, No. 1, 2007, pp. 159-162. doi:10.1017/S0950268806006601

 
 
Top