OJPsych  Vol.2 No.4 , October 2012
The subgenual cingulate gyrus exhibits lower rates of bifurcation in schizophrenia than in controls, bipolar disorder and depression
Abstract: The subgenual cingulate cortex has been found to be different in structure and function in mood and affective disorders compared to healthy individuals. Imaging studies have shown a decrease in function of the subgenual region in bipolar disorder and depression, with overall glial number shown to be decreased in these disorders. Decreases in subgenual grey matter in SZ have been observed also. In this neuropathological study upon formalin-fixed coronal brain sections we describe the morphological finding of de- creased frequency of subgenual cingulate crown bifurcation (p = 0.02) as compared to control, bipolar and depression cases. This suggests that the cingulate cortex in schizophrenia may be morphologically distinct in utero formation, potentially enabling an early identification of high-risk individuals.
Cite this paper: R. Williams, M. , K. B. Pearce, R. , R. Hirsch, S. , Ansorge, O. , Thom, M. and Maier, M. (2012) The subgenual cingulate gyrus exhibits lower rates of bifurcation in schizophrenia than in controls, bipolar disorder and depression. Open Journal of Psychiatry, 2, 253-257. doi: 10.4236/ojpsych.2012.24034.

[1]   Bechara, A., Damasio, H., Tranel, D. and Damasio, A.R. (1997) Deciding advantageously before knowing the advantageous strategy. Science, 275, 1269-1272. doi:10.1126/science.275.5304.1293

[2]   Bush, G., Vogt, B.A., Holmes, J., Dale, A.M., Greve, D. and Rosen, L.A. (2002) Dorsal anterior cingulate cortex: A role in reward-based decision making. PNAS USA, 99, 523-528. doi:10.1073/pnas.012470999

[3]   Carter, C.S., MacDonald, A.M., Botvinick, M., Ross, L.L., Stenger, V.A., Noll, D. and Cohen, J.D. (2000) Parsing executive processes: Strategic vs. evaluative functions of the anterior cingulate cortex. PNAS USA, 97, 1944-1948. doi:10.1073/pnas.97.4.1944

[4]   Carter, C.S., Mintun, M., Nichols, T. and Cohen, J.D. (1997) Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance. American Journal of Psychiatry, 154, 1670-1675.

[5]   Devinsky, O., Morrell, M.J. and Vogt, B.A. (1995) Contributions of anterior cingulate cortex to behaviour. Brain, 118, 279-306.doi:10.1093/brain/118.1.279

[6]   Kubicki, M., Westin, C.F., Nestor, P.G., Wible, C.G., Frumin, M., Maier, S.E., Kikinis, R., Jolesz, F.A., Mc- Carley, R.W. and Shenton, M.E. (2003) Cingulate fasciculus integrity disruption in schizophrenia: A magnetic resonance diffusion tensor imaging study. Biological Psychiatry, 54, 1171-1180. doi:10.1016/S0006-3223(03)00419-0

[7]   Wang, F., Sun, Z., Cui, L., Du, X., Wang, X., Zhang, H., Cong, Z., Hong, N. and Zhang, D. (2004) Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. American Journal of Psychiatry, 161, 573-575. doi:10.1176/appi.ajp.161.3.573

[8]   Kasparek, T., Prikryl, R., Mikl, M., Schwarz, D., Ceskova, E. and Krupa, P. (2006) Prefrontal but not temporal grey matter changes in males with first-episode schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31, 151-157. doi:10.1016/j.pnpbp.2006.08.011

[9]   Koo, M.S., Levitt, J.J., Salisbury, D.F., Nakamura, M., Shenton, M.E. and McCarley, R.W. (2008) A cross-sectional and longitudinal magnetic resonance imaging study of cingulate gyrus gray matter volume abnormalities in first-episode schizophrenia and first-episode affective psychosis. Archives of General Psychiatry, 65, 746-760. doi:10.1001/archpsyc.65.7.746

[10]   Kuperberg, G.R., Broome, M.R., McGuire, P.K., David, A.S., Eddy, M., Ozawa, F., Goff, D., West, W.C., Williams, S.C., van der Kouwe, A.J., Salat, D.H., Dale, A.M. and Fischl, B. (2003) Regionally localized thinning of the cerebral cortex in schizophrenia. Archives of General Psychiatry, 60, 878-888. doi:10.1001/archpsyc.60.9.878

[11]   Meisenzahl, E.M., Koutsouleris, N., Bottlender, R., Scheuerecker, J., Jager, M., Teipel, S.J., Holzinger, S., Frodl, T., Preuss, U., Schmitt, G., Burgermeister, B., Reiser, M., Born, C. and Moller, H.J. (2008) Structural brain alterations at different stages of schizophrenia: A voxelbased morphometric study. Schizophrenia Research, 104, 44-60. doi:10.1016/j.schres.2008.06.023

[12]   Narr, K.L., Bilder, R.M., Kim, S., Thompson, P.M., Szeszko, P., Robinson, D., Luders, E. and Toga, A.W. (2004) Abnormal gyral complexity in first-episode schizophrenia. Biological Psychiatry, 55, 859-867. doi:10.1016/j.biopsych.2003.12.027

[13]   Fujiwara, H., Hirao, K., Namiki, C., Yamada, M., Shimizu, M., Fukuyama, H., Hayashi, T. and Murai, T. (2007) Anterior cingulate pathology and social cognition in schizophrenia: A study of gray matter, white matter and sulcal morphometry. Neuroimage, 36, 1236-1245. doi:10.1016/j.neuroimage.2007.03.068

[14]   Baiano, M., David, A., Versace, A., Churchill, R., Balestrieri, M. and Brambilla, P. (2007) Anterior cingulate volumes in schizophrenia: A systematic review and a meta-analysis of MRI studies. Schizophrenia Research, 93, 1-12. doi:10.1016/j.schres.2007.02.012

[15]   Bouras, C., Kovari, E., Hof, P.R., Riederer, B.M. and Giannakopoulos, P. (2001) Anterior cingulate cortex pathology in schizophrenia and bipolar disorder. Acta Neuropathologica, 102, 373-379.

[16]   Nugent, A.C., Milham, M.P., Bain, E.E., Mah, L., Cannon, D.M., Marrett, S., Zarate, C.A., Pine, D.S., Price, J.L. and Drevets, W.C. (2006) Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry. Neuroimage, 30, 485-497. doi:10.1016/j.neuroimage.2005.09.029

[17]   Yucel, K., McKinnon, M.C., Chahal, R., Taylor, V.H., Macdonald, K., Joffe, R. and MacQueen, G.M. (2008) Anterior cingulate volumes in never-treated patients with major depressive disorder. Neuropsychopharmacology, 33, 3157-3163. doi:10.1038/npp.2008.40

[18]   Frodl, T., Jager, M., Born, C., Ritter, S., Kraft, E., Zetzsche, T., Bottlender, R., Leinsinger, G., Reiser, M., Moller, H.J. and Meisenzahl, E. (2008) Anterior cingulate cortex does not differ between patients with major depression and healthy controls, but relatively large anterior cingulate cortex predicts a good clinical course. Psychiatry Research, 163, 76-83. doi:10.1016/j.pscychresns.2007.04.012

[19]   Highley, J.R., Walker, M.A., Esiri, M.M., McDonald, B., Harrison, P.J. and Crow, T.J. (2001) Schizophrenia and the frontal lobes: Post-mortem stereological study of tissue volume. The British Journal of Psychiatry, 178, 337-343. doi:10.1192/bjp.178.4.337

[20]   Wright, I.C., Rabe-Hesketh, S., Woodruff, P.W., David, A.S., Murray, R.M. and Bullmore, E.T. (2000) Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry, 157, 16-25.

[21]   Williams, M.R., Chaudhry, R., Perera, S., Pearce, R.K.B., Hirsch, S.R., Ansorge, O., Thom, M. and Maier, M. (2012) Changes in cortical thickness in the frontal lobes in schizophrenia are a result of thinning of pyramidal cell layers. European Archives of Psychiatry and Clinical Neuroscience, May 19th Epub.

[22]   Heckers, S., Heinsen, H., Heinsen, Y.C. and Beckmann, H. (1990) Limbic structures and lateral ventricle in schizophrenia. A quantitative postmortem study. Archives of General Psychiatry, 47, 1016-1022. doi:10.1001/archpsyc.1990.01810230032006

[23]   Coryell, W., Nopoulos, P., Drevets, W., Wilson, T. and Andreasen, N.C. (2005) Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: Diagnostic specificity and prognostic implications. American Journal of Psychiatry, 162, 1706-1712. doi:10.1176/appi.ajp.162.9.1706

[24]   Zetzsche, T., Preuss, U., Frodl, T., Watz, D., Schmitt, G., Koutsouleris, N., Born, C., Reiser, M., Moller, H.J. and Meisenzahl, E.M. (2007) In-vivo topography of structural alterations of the anterior cingulate in patients with schizophrenia: New findings and comparison with the literature. Schizophrenia Research, 96, 34-45. doi:10.1016/j.schres.2007.07.027

[25]   Fujiwara, H., Namiki, C., Hirao, K., Miyata, J., Shimizu, M., Fukuyama, H., Sawamoto, N., Hayashi, T. and Murai, T. (2007) Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: A diffusion tensor imaging study. Schizophrenia Research, 95, 215-222. doi:10.1016/j.schres.2007.05.044

[26]   Sun, Z., Wang, F., Cui, L., Breeze, J., Du, X., Wang, X., Cong, Z., Zhang, H., Li, B., Hong, N. and Zhang, D. (2003) Abnormal anterior cingulum in patients with schizophrenia: A diffusion tensor imaging study. Neuroreport, 14, 1833-1836. doi:10.1097/00001756-200310060-00015

[27]   Kasper, B.S., Taylor, D.C., Janz, D., Kasper, E.M., Maier, M., Williams, M.R. and Crow, T.J. (2010) Neuropathology of epilepsy and psychosis: The contributions of J. A. N. Corsellis. Brain, 133, 3795-3805. doi:10.1093/brain/awq235

[28]   Williams, M.R., Hampton, T., Pearce, R.K.B., Hirsch, S.R., Ansorge, O., Thom, M. and Maier, M. (2012) Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, June 4th Epub.

[29]   Narr, K.L., Thompson, P.M., Sharma, T., Moussai, J., Zoulman, C., Rayman, J. and Toga, A.W. (2001) Three-dimensional mapping of gyral shape and cortical surface asymmetries in Schizophrenia: Gender Effects. American Journal of Psychiatry, 158, 244-255. doi:10.1176/appi.ajp.158.2.244

[30]   White, T., Andreasen, N.C., Nopoulos, P. and Magnotta, V. (2003) Gyrification abnormalities in childhood- and adolescent-onset schizophrenia. Biological Psychiatry, 54, 418-426. doi:10.1016/S0006-3223(03)00065-9

[31]   Narr, K.L., Toga, A.W., Szeszko, P., Thompson, P.M., Woods, R.P., Robinson, D., Sevy, S., Wang, Y., Schrock, K. and Bilder, R.M. (2005) Cortical thinning in cingulate and occipital cortices in first episode schizophrenia. Biological Psychiatry, 58, 32-40. doi:10.1016/j.biopsych.2005.03.043

[32]   Harris, J.M., Yates, S., Miller, P., Best, J.J., Johnstone, E.C. and Lawrie, S.M. (2004) Gyrification in first-episode schizophrenia: A morphometric study. Biological Psychiatry, 55, 141-147. doi:10.1016/S0006-3223(03)00789-3

[33]   Harris, J.M., Whalley, H., Yates, S., Miller, P., Johnstone, E.C. and Lawrie, S.M. (2004) Abnormal cortical folding in high-risk individuals: A predictor of the development of schizophrenia? Biological Psychiatry, 56, 182-189. doi:10.1016/j.biopsych.2004.04.007