U. Winkler, et al., “Characterization, Application and Potential Uses of Biotin-Tagged Inhibitors for Lymphocyte Serine Proteases (Granzymes),” Molecular Immunology, Vol. 33, No. 7-8, 1996, pp. 615-623. doi:10.1016/0161-5890(96)00025-9
 S. L. Woodard, et al., “Chymase-Directed Serine Protease Inhibitor that Reacts with a Single 30-kD: A Granzyme and Blocks NK-Mediated Cytotoxicity,” The Journal of Immunology, Vol. 153, No. 11, 1994, pp. 5016-5025.
 J. T. Thornthwaite, et al., “A Technique for Combined Light and Scanning Microscopy of Cells, Scanning Electron Microscopy,” Proceedings of the Workshop on Advances in Biomedical Applications of the SEM, IIT Research Institute, Chicago, 1976.
 J. T. Thornthwaite and R. C. Leif, “The Plaque Cytogram Assay. II. Correlation between Morphology and Density of Linear Bovine Serum Albumin Buoyant Density Grardient-Separated Immunocompetent Cells,” The Journal of Immunology, Vol. 114, No. 3, 1975. pp. 1023-1033.
 J. T. Thornthwaite, “The Characterization of the Cells Involved in Cell-Mediated Immunity against Allogeneic and Syngeneic Tumor Cells,” Ph.D. Thesis, Florida State University, Tallahassee, 1977.
 R. Kiessling, E. Klein and H. Wigzell, “Natural Killer Cells in the mouse. I. Cytotoxic Cells with Specificity for Mouse Moloney Leukemia Cells. Specificity and Distribution according to Genotype,” European Journal of Immunology, Vol. 5, No. 2, 1975, pp. 112-117. doi:10.1002/eji.1830050208
 R. Kiessling, et al., “Natural Killer Cells in the Mouse. II. Cytotoxic Cells with Specificity for Mouse Moloney Leukemia Cells. Characteristics of the Killer Cell,” European Journal of Immunology, Vol. 5, No. 2, 1975, pp. 117-121. doi:10.1002/eji.1830050209
 R. B. Herberman, M. E. Nunn and D. H. Lavrin, “Natural Cytotoxic Reactivity of Mouse Lymphoid Cells against Syn-Geneic Acid Allogeneic Tumors. I. Distribution of reactivity and specificity,” International Journal of Cancer, Vol. 16, No. 2, 1975, pp. 216-229. doi:10.1002/ijc.2910160204
 R. Kiessling, J. C. Roder and P. P. Biberfeld, “Ultrastructural and Cytochemical Studies of Mouse Natural Killer (NK) Cells,” Advances in Experimental Medicine and Biology, Vol. 121B, No. 3, 1979, pp. 155-163.
 S. Salinthone, et al., “Lipoic Acid Stimulates cAMP Pro- Duction via the EP2 and EP4 Prostanoid Receptors and Inhibits IFN Gamma Synthesis and Cellular Cytotoxicity in NK Cells,” Journal of Neuroimmunology, Vol. 199, No. 1-2, 2008, pp. 46-55. doi:10.1016/j.jneuroim.2008.05.003
 R. V. Schillace, et al., “Lipoic Acid Stimulates cAMP Production in T lymphocytes and NK Cells,” Biochemical and Biophysical Research Communications, Vol. 354, No. 1, 2007, pp. 259-264. doi:10.1016/j.bbrc.2006.12.195
 N. A. Filatova, et al., “Effect of Alpha-Lipoic Acid on the Sensitivity of Transformed Fibroblasts to Lysis by Natural Killer Cells. Comparison with NAC Action,” Tsitologiia, Vol. 51, No. 5, 2009, pp. 398-402.
 D. P. P. Belobrajdic, et al., “An Arabinoxylan-Rich Fraction from Wheat Enhances Caecal Fermentation and Protects Colonocyte DNA against Diet-Induced Damage in Pigs,” British Journal of Nutrition, 2011, pp. 1-9.
 J. R. Pritchard, et al., “A Survey of Beta-Glucan and Arabi-Noxylan Content in Wheat,” Journal of the Sci- ence of Food and Agriculture, Vol. 91, No. 7, 2011, pp. 1298-1303. doi:10.1002/jsfa.4316
 G. Muralikrishna and M. V. Rao, “Cereal Non-Cellulosic Polysaccharides: Structure and Function Relation- ship—an Overview,” Critical Reviews in Food Science and Nutrition, Vol. 47, No. 6, 2007, pp. 599-610. doi:10.1080/10408390600919056
 M. Ghoneum and S. Agrawal, “Activation of Human Monocyte-Derived Dendritic Cells in Vitro by the Biological Response Modifier Arabinoxylan Rice Bran (MGN-3/Biobran),” International Journal of Immunopathology and Pharmacology, Vol. 24, No. 4, 2011, pp. 941-948.
 M. Ghoneum and S. Gollapudi, “Synergistic Apoptotic Effect of Arabinoxylan Rice Bran (MGN-3/Biobran) and Curcumin (Turmeric) on Human Multiple Myeloma Cell Line U266 in Vitro,” Neoplasma, Vol. 58, No. 2, 2011, pp. 118-123. doi:10.4149/neo_2011_02_118
 M. H. Bang, et al., “Arabinoxylan Rice Bran, (MGN-3) Enhances the Effects of Interventional Therapies for the Treatment of Hepatocellular Carcinoma: A Three-Year Randomized Clinical Trial,” Anticancer Research, Vol. 30, No. 12, 2010, pp. 5145-5151.
 L. Cao, et al., “Antitumor and Immunomodulatory Activity of Arabinoxylans: A Major Constituent of Wheat Bran,” International Journal of Biological Macromolecules, Vol. 48, No. 1, 2011, pp. 160-164. doi:10.1016/j.ijbiomac.2010.10.014
 A. P. P. Femia, et al., “Arabinoxylan-Oligosaccharides, (AXOS) Reduce Preneoplastic Lesions in the Colon of Rats Treated with 1,2-Dimethylhydrazine (DMH),” Euro- pean Journal of Nutrition, Vol. 49, No. 2, 2010, pp. 127- 132. doi:10.1007/s00394-009-0050-x
 E. Noaman, et al., “Antioxidant Potential by Arabinoxlan Rice Bran, MGN-3/Biobran, Represents a Mechanism for Its Oncostatic Effect against Murine Solid Ehrlich Carcinoma,” Cancer Letters, Vol. 268, No. 2, 2008, pp. 348-359. doi:10.1016/j.canlet.2008.04.012
 N. K. Badr El-Din, E. Noaman and M. Ghoneum, “In Vivo Tumor Inhibitory Effects of Nutritional Rice Bran Supplement MGN-3/Biobran on Ehrlich Carcnoma-Bearing Mice,” Nutrition and Cancer, Vol. 60, No. 2, 2008, pp. 235-244. doi:10.1080/01635580701627285
 S. Gollapudi and M. Ghoneum, “MGN-3/Biobran, Modified Arabinoxylan from Rice Bran, Sensitizes Human Breast Cancer Cells to Chemotherapeutic Agent, Daun- orubicin,” Cancer Detection and Prevention, Vol. 32, No. 1, 2008, pp. 1-6. doi:10.1016/j.cdpp.2008.02.006
 M. Glei, et al., “Both Wheat, (Triticum aestivum) Bran Arabinoxylans and Gut Flora-Mediated Fermentation Products Protect Human Colon Cells from Genotoxic Activeties of 4-Hydroxynonenal and Hydrogen Peroxide,” Journal of Agricultural and Food Chemistry, Vol. 54, No. 6, 2006, pp. 2088-2095. doi:10.1021/jf052768e
 M. Ghoneum and S. Gollapudi, “Synergistic Role of Ara- Binoxylan Rice Bran, (MGN-3/Biobran) in S. Cere- Visiae-Induced Apoptosis of Monolayer Breast Cancer MCF-7 Cells,” Anticancer Research, Vol. 25, No. 6B, 2005, pp. 4187-4196.
 K. Ogawa, M. Takeuchi and N. Nakamura, “Immunological Effects of Partially Hydrolyzed Arabinoxylan from Corn Husk in Mice,” Bioscience, Biotechnology and Biochemistry, Vol. 69, No. 1, 2005, pp. 19-25. doi:10.1271/bbb.69.19
 H. Maeda, et al., “Oral Administration of Hydrolyzed Rice Bran Prevents the Common Cold Syndrome in the Elderly Based on Its Immunomodulatory Action,” Biofactors, Vol. 21, No. 1-4, 2004, pp. 185-187. doi:10.1002/biof.552210138
 M. Ghoneum and S. Abedi, “Enhancement of Natural Killer Cell Activity of Aged Mice by Modified Arabinoxylan Rice Bran, (MGN-3/Biobran),” Journal of Pharmacy and Pharmacology, Vol. 56, No. 12, 2004, pp. 1581-1588. doi:10.1211/0022357044922
 M. Ghoneum and A. Jewett, “Production of Tumor NecroSis Factor-Alpha and Interferon-Gamma from Human Pe- Ripheral Blood Lymphocytes by MGN-3, a Modified Ara-Binoxylan from Rice Bran, and Its Synergy with Inter-Leukin-2 In Vitro,” Cancer Detection and Prevention, Vol. 24, No. 4, 2000, pp. 314-324.
 L. M. Ferrucci, et al., “Measurement of Spices and Sea- Sonings in India: Opportunities for Cancer Epidemiology and Prevention,” Asian Pacific Journal of Cancer Prevention, Vol. 11, No. 6, 2010, pp. 1621-1629.
 H. G. Zhang, et al., “Curcumin Reverses Breast Tumor Exosomes Mediated Immune Suppression of NK Cell Tumor Cytotoxicity,” Biochimica et Biophysica Acta, Vol. 1773, No. 7, 2007, pp. 1116-23. doi:10.1016/j.bbamcr.2007.04.015
 M. A. Bill, et al., “The Small Molecule Curcumin Analog FLLL32 Induces Apoptosis in Melanoma Cells via Stat3 Inhibition and Retains the Cellular Response to Cytokines with Anti-Tumor Activity,” Molecular Cancer, Vol. 9, No., 2010, p. 165. doi:10.1186/1476-4598-9-165
 S. Bhaumik, M. D. Jyothi and A. Khar, “Differential Modulation of Nitric Oxide Production by Curcumin in Host Macrophages and NK Cells,” FEBS Letters, Vol. 483, No. 1, 2000, pp. 78-82. doi:10.1016/S0014-5793, No. 00)02089-5
 M. A. Bill, et al., “Curcumin Induces Proapoptotic Effects against Human Melanoma Cells and Modulates the Cellu-Lar Response to Immunotherapeutic Cytokines,” Molecular Cancer Therapeutics, Vol. 8, No. 9, 2009, pp. 2726-2735. doi:10.1158/1535-7163.MCT-09-0377
 C. C. Li, et al., “A Study on the Construction, Expression and Immunosterility of Lagurus Laguru Zona Pellucida 3 DNA Vaccine pVAX1-sig-LTB-LZP3-C3d3,” Chinese Journal of Cellular and Molecular Immunology, Vol. 27, No. 9, 2011, pp. 941-944.
 J. J. Lu, Y. J. Cai and J. Ding, “The Short-Time Treatment with Curcumin Sufficiently Decreases Cell Viability, Induces Apoptosis and Copper Enhances These Effects in Multidrug-Resistant K562/A02 Cells,” Molecular and Cellular Biochemistry, Vol. 360, No. 1-2, 2012, pp. 253- 260. doi:10.1007/s11010-011-1064-2
 M. Bright-Gbebry, et al., “Use of Multivitamins, Folic Acid and Herbal Supplements among Breast Cancer Survivors: The Black Women’s Health Study,” BMC Complementary and Alternative Medicine, Vol. 11, 2011, p. 30. doi:10.1186/1472-6882-11-30
 C. A. Gonzalez, et al., “Fruit and Vegetable Intake and the Risk of Gastric Adenocarcinoma: A Reanalysis of the European Prospective Investigation into Cancer and Nu- Triation, (EPIC-EURGAST) Study after a Longer Follow-Upp,” International Journal of Cancer, Vol. 131, No. 12, 2012, pp. 2910-2919. doi:10.1002/ijc.27565
 Y. Zhou, et al., “Consumption of Large Amounts of Allium Vegetables Reduces Risk for Gastric Cancer in a Meta-Analysis,” Gastroenterology, Vol. 141, No. 1, 2011, pp. 80-89. doi:10.1053/j.gastro.2011.03.057
 T. Ghazanfari, et al., “In Vitro Cytotoxic Effect of Garlic Extract on Malignant and Nonmalignant Cell Lines,” Immunopharmacol and Immunotoxicol, Vol. 33, No. 4, 2011, pp. 603-608. doi:10.3109/08923973.2011.551832
 M. S. Butt, M. T. Sultan and J. Iqbal, “Garlic: Nature’s Protection against Physiological Threats,” Critical Reviews in Food Science and Nutrition, Vol. 49, No. 6, 2009, pp. 538-551. doi:10.1080/10408390802145344
 D. L. Lamm and D. R. Riggs, “The Potential Application Of Allium Sativum, (Garlic) for the Treatment of Bladder Cancer,” Urologic Clinics of North America, Vol. 27, No. 1, 2000, pp. 157-162, doi:10.1016/S0094-0143, No. 05)70243-3
 Z. M. Hassan, et al., “Immunomodulatory Affect of R10 Fraction of Garlic Extract on Natural Killer Activity,” International Immunopharmacology, Vol. 3, No. 10-11, 2003, pp. 1483-1489. doi:10.1016/S1567-5769, No. 03)00161-9
 Z. Tang, et al., “The Preventing Function of Garlic on Experimental Oral Precancer and Its Effect on Natural Killer Cells, T-Lymphocytes and Interleukin-2,” Bulletin of Hunan Medical University, Vol. 22, No. 3, 1997, pp. 246-248.
 S.-H. Kim, A. Bommareddy and S. V. Singh, “Garlic Constituent Diallyl Trisulfide Suppresses X-Linked Inhibitor of Apoptosis Protein in Prostate Cancer Cellsin Culture and in Vivo,” Cancer Prevention Research, Vol. 4, No. 6, 2011, pp. 897-906. doi:10.1158/1940-6207.CAPR-10-0323
 X. Wu, et al., “Proteasome Inhibitor Lactacystin Augments Natural Killer Cell Cytotoxicity of Myeloma Via Downregu-Lation of Hla Class I,” Biochemical and Biophysical Research Communications, Vol. 415, No. 1, 2011, pp. 187-192. doi:10.1016/j.bbrc.2011.10.057
 P. P. Wu, et al., “Diallyl Trisulfide (DATS) Inhibits Mouse Colon Tumor in Mouse CT-26 Cells Allograft Model in Vivo,” Phytomedicine, Vol. 18, No. 8-9, 2011, pp. 672-676. doi:10.1016/j.phymed.2011.01.006
 P. P. Wu, et al., “Diallyl Sulfide Induces Cell Cycle Arrest and Apoptosis in Hela Human Cervical Cancer Cells through the p53, Caspase- and Mitochondria-Dependent Pathways,” International Journal of Oncology, Vol. 38, No. 6, 2011, pp. 1605-1613.
 H. Javed, et al., “S-allyl Cysteine Attenuates Oxidative Stress Associated Cognitive Impairment and Neurodegen- Eration in Mouse Model of Streptozotocin-Induced Expe- Rimental Dementia of Alzheimer’s Type,” Brain Re- search, Vol. 1389, 2011, pp. 133-142. doi:10.1016/j.brainres.2011.02.072
 N. Morioka, et al., “A Protein Fraction from Aged Garlic Extract Enhances Cytotoxicity and Proliferation of Human Lymphocytes Mediated by Interleukin-2 and Concanavalin A,” Cancer Immunology, Immunotherapy, Vol. 37, No. 5, 1993, pp. 316-322. doi:10.1007/BF01518454
 J. H. Cha, et al., “Allicin Inhibits Cell Growth and Induces Apoptosis in U87MG Human Glioblastoma Cells through an Erk-Dependent Pathway,” Oncology Reports, Vol. 28, No. 1, 2012, pp. 41-48. doi:10.1007/BF01518454
 Y. M. Nkrumah-Elie, et al., “Diallyl trisulfide as an Inhibitor of Benzo (a) Pyrene-Induced Precancerous Carcinogenesis in MCF-10A Cells,” Food and Chemical Toxicology, Vol. 50, No. 7, 2012, pp. 2542-2530. doi:10.1016/j.fct.2012.04.010
 J. E. Lee, et al., “Induction of Apoptosis with Diallyl Disul-Fide in Ags Gastric Cancer Cell Line,” Journal of the Korean Surgical Society, Vol. 81, No. 2, 2011, pp. 85-95. doi:10.4174/jkss.2011.81.2.85
 J. H. Lee, et al., “1, 25-Dihydroxyvitamin D3 Enhances NK Susceptibility of Human Melanoma Cells via Hsp60-Mediated FAS Expression,” European Journal of Immunology, Vol. 41, No. 10, 2011, pp. 2937-2946. doi:10.1002/eji.201141597
 Y. Lee, et al., “Anticancer Activity of S-Allylmercapto- L-Cysteine on Implanted Tumor of Human Gastric Cancer Cell,” Biological and Pharmaceutical Bulletin, Vol. 34, No. 5, 2011, pp. 677-681. doi:10.1248/bpb.34.677
 E. J. Kim, et al., “Thiacremonone, a Sulfur Compound Isolated from Garlic, Attenuates Lipid Accumulation Partially Mediated via AMPK Activation in 3T3-L1 Adipo- cytes,” The Journal of Nutritional Bioch, 2012. doi:10.1016/j.jnutbio.2011.10.008
 A. A. Powolny, et al., “The Garlic Constituent Diallyl Trisulfide Increases the Lifespan of C. Elegans via SKN-1 Activation,” Experimental Gerontology, Vol. 46, No. 6, 2011, pp. 441-442. doi:10.1016/j.exger.2011.01.005
 R. Nepravishta, et al., “Oxidative Species and SGlutathionyl Conjugates in the Apoptosis Induction by Allyl Thiosulfate,” FEBS Journal, Vol. 279, No. 1, 2012, pp. 154-167. doi:10.1111/j.1742-4658.2011.08407.x
 M. H. Pai, et al., “S-Allylcysteine Inhibits Tumour Progression and the Epithelial-Mesenchymal Transition in a Mouse Xenograft Model of Oral Cancer,” British Journal of Nutrition, Vol. 108, No. 1, 2011, pp. 1-11.
 Y. Pei, et al., “Hydrogen Sulfide Mediates the Anti-Survival Effect of Sulforaphane on Human Prostate Cancer Cells,” ology and Applied Pharmacology, Vol. 257, No. 3, 2011, pp. 420-428. doi:10.1016/j.taapp.2011.09.026
 Z. Wang, et al., “Resveratrol Induces Gastric Cancer Cell Apoptosis via Reactive Oxygen Species, but Independent of Sirtuin1,” Clinical and Experimental Pharmacology and Physiology, Vol. 39, No. 3, 2012, pp. 227-232. doi:10.1111/j.1440-1681.2011.05660.x
 F. Wang, et al., “Long-Term Efficacy of 10-12 Years after Being Immunized with Chinese Hamster Ovary Cell Derived Hepatitis B Vaccine in Chinese Rural Communities,” Vaccine, Vol. 30, No. 12, 2012, pp. 2051-2053. doi:10.1016/j.vaccine.2012.01.052
 M. O. Altonsy and S. C. Andrews, “Diallyl Disulphide, A Beneficial Component of Garlic Oil, Causes a Redistribution of Cell-Cycle Growth Phases, Induces Apoptosis, and Enhances Butyrate-Induced Apoptosis in Colorectal Adeno-Carcinoma Cells (HT-29),” Nutrition and Cancer, Vol. 63, No. 7, 2011, pp. 1104-1113. doi:10.1080/01635581.2011.601846
 C. Y. Chen, et al., “Diallyl Disulfide Induces Ca2+ Mobi- Lization in Human Colon Cancer Cell Line SW480,” Archives of Toxicology, Vol. 86, No. 2, 2012, pp. 231-238. doi:10.1007/s00204-011-0748-4
 B. Akgul, et al., “Garlic Accelerates Red Blood Cell Turnover and Splenic Erythropoietic Gene Expression in Mice: Evidence for Erythropoietin-Independent Erythropoiesis,” PLOS One, Vol. 5, No. 12, 2010, p. e15358. doi:10.1371/journal.pone.0015358
 C. Cerella, et al., “Chemical Properties and Mechanisms Determining the Anti-Cancer Action of Garlic-Derived or Ganic Sulfur Compounds,” Anti-Cancer Agents in Medicinal Chemistry, Vol. 11, No. 3, 2011, pp. 267-271.
 C. Ma, et al., “Production, Characterisation and Immuno- Genicity of a Plant-Made Plasmodium Antigen—The 19 kDa C-Terminal Fragment of Plasmodium Yoelii Merozoite Surface Protein 1,” Applied Microbiology and Biotechnology, Vol. 94, No. 1, 2012, pp. 151-161. doi:10.1007/s00253-011-3772-7
 J. L. Ma, et al., “Fifteen-Year Effects of Helicobacter Pylori, Garlic, and Vitamin Treatments on Gastric Cancer Incidence and Mortality,” Journal of the National Cancer Institute, Vol. 104, No. 6, 2012, pp. 488-492. doi:10.1093/jnci/djs003
 Q. Ma and Y. Wang, “Comprehensive Analysis of the Prevalence of Hepatitis B Virus Escape Mutations in the Major Hydrophilic Region of Surface Antigen,” Journal of Medical Virology, Vol. 84, No. 2, 2012, pp. 198-206. doi:10.1002/jmv.23183
 M. L. Antony and S. V. Singh, “Molecular Mechanisms and Targets of Cancer Chemoprevention by Garlic-Derived Bioactive Compound Diallyl Trisulfide,” Indian Journal of Experimental Biology, Vol. 49, No. 11, 2011, pp. 805-816.
 M. Iciek, et al., “The Effects of Garlic-Derived Sulfur Compounds on Cell Proliferation, Caspase 3 Activity, Thiol Levels and Anaerobic Sulfur Metabolism in Human Hepato-Blastoma HepG2 Cells,” Cell Biochemistry and Function, Vol. 30, No. 3, 2012, pp. 198-204. doi:10.1002/cbf.1835
 H. Shirzad, F. Taji and M. Rafieian-Kopaei, “Correlation between Antioxidant Activity of Garlic Extracts and WEHI-164 Fibrosarcoma Tumor Growth in BALB/c Mice,” Journal of Medicinal Food, Vol. 14, No. 9, 2011, pp. 969-974. doi:10.1089/jmf.2011.1594
 R. B. Walter, et al., “Vitamin, Mineral, and Specialty Supplements and Risk of Hematologic Malignancies in the Prospective VITamins and Lifestyle (VITAL) Study,” Cancer Epidemiology, Biomarkers & Prevention, Vol. 20, No. 10, 2011, pp. 2298-2308. doi:10.1158/1055-9965.EPI-11-0494
 D. Liang, et al., “S-Allylmercaptocysteine Effectively In- Hibits the Proliferation of Colorectal Cancer Cells under in Vitro and in Vivo Conditions,” Cancer Letters, Vol. 310, No. 1, 2011, pp. 69-76. doi:10.1016/j.canlet.2011.06.019
 Y. S. Huang, et al., “Diallyl Disulfide Inhibits the Proliferation of HT-29 Human Colon Cancer Cells by Inducing Differentially Expressed Genes,” Molecular Medicine Reports, Vol. 4, No. 3, 2011, pp. 553-559.
 H. Hu, et al., “Identification of a Novel Function of Id-1 in Mediating the Anticancer Responses of Samc, a Water-Soluble Garlic Derivative, in Human Bladder Cancer Cells,” Molecular Medicine Reports, Vol. 4, No. 1, 2011, pp. 9-16.
 E. Viry, et al., “Antiproliferative Effect of Natural Tetrasul-Fides in Human Breast Cancer Cells Is Mediated Through the Inhibition of the Cell Division Cycle 25 Phosphatases,” International Journal of Oncology, Vol. 38, No. 4, 2011, pp. 1103-1111.
 V. Karagianni, et al., “Risk Factors for Colorectal Polyps: Findings from a Greek Case-Control Study,” Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi, 2010, Vol. 114, No. 3, pp. 662-670.
 T. Chihara, et al., “Inhibition of 1, 2-Dimethylhydra- Zine-Induced Mucin-Depleted Foci and O (6)-Methyl- Guanine DNA Adducts in the Rat Colorectum by Boiled Garlic Powder,” Asian Pacific Journal of Cancer Prevention, Vol. 11, No. 5, 2010, pp. 1301-1304.
 N. Ferrari, et al., “Diet-Derived Phytochemicals: From Cancer Chemoprevention to Cardio-Oncological Prevention,” Current Drug Targets, Vol. 12, No. 13, 2011, pp. 1909-1924. doi:10.2174/138945011798184227
 B. Ray, N. B. Chauhan and D. K. Lahiri, “The Aged Garlic Extract (AGE) and One of Its Active Ingredients S-Allyl-L-Cysteine (SAC) as Potential Preventive and Therapeutic Agents for Alzheimer’s Disease (AD),” Current Drug Targets, Vol. 18, No. 22, 2011, pp. 3306-3313. doi:10.2174/092986711796504664
 K. C. Lai, et al., “Diallyl Sulfide, Diallyl Disulfide, and Diallyl Trisulfide Inhibit Migration and Invasion in Human Colon Cancer Colo 205 Cells through the Inhibition of Matrix Metalloproteinase-2, -7, and -9 Expressions,” Environmental Toxicology, Vol. 3, 2011. doi:10.1002/tox.20737
 M. Miroddi, F. Calapai and G. Calapai, “Potential Bene- Ficial Effects of Garlic in Oncohematology,” MiniReviews in Medicinal Chemistry, Vol. 11, No. 6, 2011, pp. 461-472. doi:10.2174/138955711795843293
 R. Marik, et al., “Potent Genistein Derivatives as Inhibitors of Estrogen Receptor Alpha-Positive Breast Cancer,” Cancer Biology & Therapy, Vol. 11, No. 10, 2011, pp. 883-892. doi:10.4161/cbt.11.10.15184
 T. L. Guo, et al., “Genistein Modulates Splenic Natural Killer Cell Activity, Antibody-Forming Cell Response, and Phenotypic Marker Expression in F(0) and F(1) Generations of Sprague-Dawley Rats,” Toxicology and Applied Pharmacology, Vol. 181, No. 3, 2002, pp. 219-227.
 M. F. Ullah, et al., “Soy Isoflavone Genistein Induces Cell Death in Breast Cancer Cells through Mobilization of Endogenous Copper Ions and Generation of Reactive Oxygen Species,” Mol Nutr Food Res Molecular Nutrition & Food Research, Vol. 55, No. 4, 2011, pp. 553-559. doi:10.1002/mnfr.201000329
 X. Yu, et al., “Anti-Angiogenic Genistein Inhibits VEGF- Induced Endothelial Cell Activation by Decreasing PTK Activity and Mapk Activation,” Medical Oncology, Vol. 29, No. 1, 2012, pp. 349-357. doi:10.1007/s12032-010-9770-2
 F. Polito, et al., “Genistein Aglycone, a Soy-Derived Isoflavone, Improves Skin Changes Induced by Ovariectomy in Rats,” British Journal of Pharmacology, Vol. 165, No. 4, 2012, pp. 994-1005. doi:10.1111/j.1476-5381.2011.01619.x
 Y. Zhang and H. Chen, “Genistein Attenuates WNT Signaling by Up-Regulating sFRP2 in a Human Colon Cancer Cell Line,” Experimental Biology and Medicine (Maywood) Vol. 236, No. 6, 2011, pp. 714-722. doi:10.1258/ebm.2011.010347
 M. B. van Duursen, et al., “Genistein Induces Breast Cancer-Associated Aromatase and Stimulates Estrogen-Dependent Tumor Cell Growth in Vitro Breast Cancer Model,” Toxicology, Vol. 289, No. 2-3, 2011, pp. 67-73. doi:10.1016/j.tox.2011.07.005
 C. Sanchez, et al., “Chemotherapy Sensitivity Recovery of Prostate Cancer Cells by Functional Inhibition and Knock down of Multidrug Resistance Proteins,” Prostate, Vol. 71, No. 16, 2011, pp. 1810-1817. doi:10.1002/pros.21398
 W. Qi, et al., “Genistein Inhibits Proliferation of Colon Cancer Cells by Attenuating a Negative Effect of Epidermal Growth Factor on Tumor Suppressor FOXO3 Activity,” BMC Cancer, Vol. 11, 2011, pp. 219. doi:10.1186/1471-2407-11-219
 G. Ji, et al., “Anti-Inflammatory Effect of Genistein on Non-Alcoholic Steatohepatitis Rats Induced by High Fat Diet and Its Potential Mechanisms,” International Immunopharmacology, Vol. 11, No. 6, 2011, pp. 762-768. doi:10.1016/j.intimpp.2011.01.036
 D. Hess and R. A. Igal, “Genistein Downregulates Denovo Lipid Synthesis and Impairs Cell Proliferation in Human Lung Cancer Cells,” Experimental Biology and Medicine, Vol. 236, No. 6, 2011, pp. 707-713. doi:10.1258/ebm.2011.010265
 S. de Assis, et al., “Protective Effects of Prepubertal Gen- Istein Exposure on Mammary Tumorigenesis Are Depend-ENT on Brca1 Expression,” Cancer Prevention Re- search, Vol. 4, No. 9, 2011, pp. 1436-1448. doi:10.1158/1940-6207.CAPR-10-0346
 F. G. Bottone Jr. and B. Alston-Mills, “The Dietary Com- Pounds Resveratrol and Genistein Induce Activating Transcription Factor 3 While Suppressing Inhibitor of DNA Binding/Differentiation-1,” Journal of Medicinal Food, Vol. 14, No. 6, 2011, pp. 584-593. doi:10.1089/jmf.2010.0110
 Y. Zhang, et al., “Genistein Inhibits Osteolytic Bone Me- Tastasis and Enhances Bone Mineral in Nude Mice,” Environmental Toxicology and Pharmacology, Vol. 30, No. 1, 2010, pp. 37-44. doi:10.1016/j.etapp.2010.03.016
 M. Yamasaki, et al., “Genistein Induced Apoptotic Cell Death in Adult T-Cell Leukemia Cells through Estrogen Receptors,” Bioscience, Biotechnology, and Biochemistry, Vol. 74, No. 10, 2010, pp. 2113-2115. doi:10.1271/bbb.100359
 I. Hwang, et al., “An Acidic Polysaccharide of Panax Ginseng Ameliorates Experimental Autoimmune Encephalo-Myelitis and Induces Regulatory T Cells,” Immunology Letters, Vol. 138, No. 2, 2011, pp. 169-178. doi:10.1016/j.imlet.2011.04.005
 J. L. Elam, et al., “Methodological Issues in the Investigation of Ginseng as an Intervention for Fatigue,” Clini- cal Nurse Specialist, Vol. 20, No. 4, 2006, pp. 183-189. doi:10.1097/00002800-200607000-00007
 F. Y. Xie, Z. F. Zeng and H. Y. Huang, “Clinical Observation on Nasopharyngeal Carcinoma Treated with Combined Therapy of Radiotherapy and Ginseng Polysaccharide Injection,” Chinese Journal of Integrated Traditional and Western Medicine, Vol. 21, No. 5, 2001, pp. 332-334.
 H. Nakata, et al., “Inhibitory Effects of Ginsenoside RH2 on Tumor Growth in Nude Mice Bearing Human Ovarian Cancer Cells,” Japanese Journal of Cancer Research, Vol. 89, No. 7, 1998, pp. 733-740. doi:10.1111/j.1349-7006.1998.tb03278.x
 D. M. See, et al., “In Vitro Effects of Echinacea and Ginseng on Natural Killer and Antibody-Dependent Cell Cytotoxicity in Healthy Subjects and Chronic Fatigue Syndrome or Acquired Immunodeficiency Syndrome Patients,” Immunopharmacology, Vol. 35, No. 3, 1997, pp. 229-235. doi:10.1016/S0162-3109, No. 96)00125-7
 S. Y. Lin, L. M. Liu and L. C. Wu, “Effects of Shenmai Injection on Immune Function in Stomach Cancer Patients after Chemotherapy,” Chinese Journal of Integrated Traditional and Western Medicine, Vol. 15, No. 8, 1995, pp. 451-453.
 Y. S. Yun, et al., “Inhibition of Autochthonous Tumor by Ethanol Insoluble Fraction from Panax Ginseng as an Immunomodulator,” Planta Medica, Vol. 59, No. 6, 1993, pp. 521-524. doi:10.1055/s-2006-959752
 S. P. Wasser, “Medicinal Mushrooms as a Source of Antitumor and Immunomodulating Polysaccharides,” Applied Microbiology and Biotechnology, 2002, Vol. 60, No. 3, pp. 258-274. doi:10.1007/s00253-002-1076-7
 M. Suzuki, et al., “Curative Effects of Combination Therapy with Lentinan and Interleukin-2 against Established Murine Tumors, and the Role of CD8-Positive T cells,” Cancer Immunology, Immunotherapy, Vol. 38, No. 1, 1994, pp. 1-8. doi:10.1007/BF01517163
 M. Suzuki, et al., “Reconstitution of Anti-Tumor Effects of Lentinan in Nude Mice: Roles of Delayed-Type Hypersensitivity Reaction Triggered by CD4-Positive T cell Clone in the Infiltration of Effector Cells into Tumor,” Japanese Journal of Cancer Research, Vol. 85, No. 4, 1994, pp. 409-417. doi:10.1111/j.1349-7006.1994.tb02374.x
 V. Vetvicka, et al., “Enhancing Effects of New Biological Response Modifier Beta-1,3 Glucan Sulfate PS3 on Immune Reactions,” Biomedicine & Pharmacotherapy, Vol. 62, No. 5, 2008, pp. 283-288. doi:10.1016/j.biopha.2007.05.011
 J. Wang, Z. D. Zhou and D. J. Xia, “Study on Effect of Lentinan in Enhancing Anti-Tumor Action of Dendritic Cytoma Vaccine and Its Mechanism,” Chinese Journal of Integrated Traditional and Western Medicine, Vol. 27, No. 1, 2007, pp. 60-64.
 M. L. Ng and A. T. Yap, “Inhibition of Human Colon Carcinoma Development by Lentinan from Shiitake Mushrooms (Lentinus Edodes),” Journal of Alternative and Complementary Medicine, Vol. 8, No. 5, 2002, pp. 581-589. doi:10.1089/107555302320825093
 K. Hamano, et al., “The Preoperative Administration of Lentinan Ameliorated the Impairment of Natural Killer Activity after Cardiopulmonary Bypass,” International Journal of Immunopharmacology, Vol. 21, No. 8, 1999, pp. 531-540. doi:10.1016/S0192-0561, No. 99)00033-8
 J. F. Li, J. W. Guo and X. F. Huang, “Study on the Enhancing Effect of Polyporus Polysaccharide, Mycobacterium Polysaccharide and Lentinan on Lymphokine-Activated Killer Cell Activity in Vitro,” Chinese Journal of Integrated Traditional and Western Medicine, Vol. 16, No. 4, 1996, pp. 224-226.
 M. Rafique and W. Adachi, “Effects of Intraportal Administration of Chemoimmunotherapeutic Agents on Natural Killer Cell Activity in the Rat Liver,” Journal of Surgical Oncology, Vol. 60, No. 3, 1995, pp. 154-159. doi:10.1002/jso.2930600304
 H. Matsuoka, et al., “Usefulness of Lymphocyte Subset Change as an Indicator for Predicting Survival Time and Effectiveness of Treatment with the Immunopotentiator Lentinan,” Anticancer Research, Vol. 15, No. 5B, 1995, pp. 2291-2296.
 S. Hazama, et al., “Clinical Effects and Immunological Analysis of Intraabdominal and Intrapleural Injection of Lentinan for Malignant Ascites and Pleural Effusion of Gastric Carcinoma,” Japanese Journal of Cancer and Chemotherapy, Vol. 22, No. 11, 1995, pp. 1595-1597.
 H. Morinaga, et al., “An in Vivo Study of Hepatic and Splenic Interleukin-1 Beta mRNA Expression Following Oral PSK or LEM Administration,” Japanese Journal of Cancer Research, Vol. 85, No. 12, 1994, pp. 1298-1303. doi:10.1111/j.1349-7006.1994.tb02943.x
 J. Hamuro, et al., “Synergistic Antimetastatic Effects of Lentinan and Interleukin 2 with Pre- and Post-Operative Treatments,” Japanese Journal of Cancer Research, Vol. 85, No. 12, 1994, pp. 1288-1297. doi:10.1111/j.1349-7006.1994.tb02942.x
 Z. B. Yang, “Effects of Pretreatment with Lentinan or Krestin on Antitumor Effector Cell Activities Suppressed by Cyclophosphamide,” Hokkaido Journal of Medical Science, Vol. 69, No. 1, 1994, pp. 137-145.
 S. Arinaga, et al., “Enhanced Induction of Lymphokine- Activated Killer Activity after Lentinan Administration in Patients with Gastric Carcinoma,” International Journal of Immunopharmacology, Vol. 14, No. 4, 1992, pp. 535- 539. doi:10.1016/0192-0561, No. 92)90114-Z
 M. Tani, et al., “In Vitro Generation of Activated Natural Killer Cells and Cytotoxic Macrophages with Lentinan,” European Journal of Clinical Pharmacology, Vol. 42, No. 6, 1992, pp. 623-627. doi:10.1007/BF00265926
 M. Takahashi, et al., “Two-Color Flow Cytometric Analysis of Splenic Lymphocyte Subpopulations in Patients with Gastric Cancer,” Surgery Today, Vol. 22, No. 1, 1992, pp. 35-39. doi:10.1007/BF00326123
 M. Oka, et al., “Immunological Analysis and Clinical Effects of Intraabdominal and Intrapleural Injection of Lentinan for Malignant Ascites and Pleural Effusion,” Biotherapy, Vol. 5, No. 2, 1992, pp. 107-112. doi:10.1007/BF02171695
 H. Tanabe, N. Imai and K. Takechi, “Studies on Usefulness of Postoperative Adjuvant Chemotherapy with Lentinan in Patients with Gastrointestinal Cancer,” Journal of Japan Society for Magazine Subscription, Vol. 25, No. 8, 1990, pp. 1657-1667.
 M. Suzuki, et al., “Induction of Endogenous Lymphokine-Activated Killer Activity by Combined Admini- stration of Lentinan and Interleukin 2,” International Journal of Immunopharmacology, Vol. 12, No. 6, 1990, pp. 613-623. doi:10.1016/0192-0561, No. 90)90098-8
 H. Shimizu, M. Inoue and O. Tanizawa, “Adoptive Cellular Immunotherapy to the Endometrial Carcinoma Cell Line Xenografts in Nude Mice,” Gynecologic Oncology, Vol. 34, No. 2, 1989, pp. 195-199. doi:10.1016/0090-8258, No. 89)90141-8
 S. Yoshino, et al., “Effect of Intrapleural and/or Intraperitoneal Lentinan Therapy on Carcinomatous Pleuritis and Peritonitis with Special Reference to Immunological Evaluation,” Nihon Geka Hokan, Vol. 58, No. 3, 1989, pp. 310-319.
 K. Yamasaki, et al., “Synergistic Induction of Lymphokine, (IL-2)-Activated Killer Activity by IL-2 and the Polysaccharide Lentinan, and Therapy of Spontaneous Pulmonary Metastases,” Cancer Immunology, Immuno- therapy, Vol. 29, No. 2, 1989, pp. 87-92. doi:10.1007/BF00199282
 T. Inagaki, K. Morise and H. Matsunaga, “Effects of Endoscopic Intratumoral Injection of Lentinan in Patients with Gastric Cancer,” Japanese Journal of Cancer and Chemotherapy, Vol. 15, No. 2, 1988, pp. 319-324.
 M. Akimoto, T. Nishihira and M. Kasai, “Modulation of the Anti-Tumor Effect of BRM under Various Nutritional or Endocrine Conditions,” Japanese Journal of Cancer and Chemotherapy, Vol. 13, No. 4, 1986, pp. 1270-1276.
 H. Miyakoshi, T. Aoki and M. Mizukoshi, “Acting Mechanisms of Lentinan in Human—II. Enhancement of Non-Specific Cell-Mediated Cytotoxicity as an Interferon Inducer,” International Journal of Immunopharmacology, Vol. 6, No. 4, 1984, pp. 373-379. doi:10.1016/0192-0561, No. 84)90057-2
 M. Amino, et al., “Studies on the Effect of Lentinan on Human Immune System. II. in Vivo effect on NK Activity, MLR Induced Killer Activity and Pha Induced Blastic Response of Lymphocytes in Cancer Patients,”. Japanese Journal of Cancer and Chemotherapy, Vol. 10, No. 9, 1983, pp. 2000-2006.
 K. Kurita, et al., “Synthesis and Macrophage Activation of Lentinan-Mimic Branched Amino Polysaccharides: Curdlans Having N-Acetyl-D-Glucosamine Branches,” Biomacromolecules, Vol. 12, No. 6, 2011, pp. 2267-2274. doi:10.1021/bm200353m
 K. Harada, et al., “Effects of Lentinan Alone and in Combination with Fluoropyrimidine Anticancer Agent on Growth of Human Oral Squamous Cell Carcinoma in Vitro and in Vivo,” International Journal of Oncology, Vol. 37, No. 3, 2010, pp. 623-631. doi:10.3892/ijo_00000711
 E. McCormack, et al., “Lentinan: Hematopoietic, Immunological, and Efficacy Studies in a Syngeneic Model of Acute Myeloid Leukemia,” Nutrition and Cancer, Vol. 62, No. 5, 2010, pp. 574-583. doi:10.1080/01635580903532416
 X. Wang, et al., “Effects of Potential Calcium Sensing Receptor Inducers on Promoting Chemosensitivity of Human Colon Carcinoma Cells,” International Journal of Oncology Vol. 36, No. 6, 2010, pp. 1573-1580.
 N. Isoda, et al., “Clinical Efficacy of Superfine Dispersed Lentinan, No. Beta-1,3-Glucan) in Patients with Hepatocellular Carcinoma,” Hepatogastroenterology, Vol. 56, No. 90, 2009, pp. 437-441.
 H. Mushiake, et al., “Dendritic Cells Might Be One of Key Factors for Eliciting Antitumor Effect by Chemoimmunotherapy in Vivo,” Cancer Immunology, Immunotherapy, Vol. 54, No. 2, 2005, pp. 120-128. doi:10.1007/s00262-004-0585-x
 S. Yoshino, et al., “Immunoregulatory Effects of the Antitumor Polysaccharide Lentinan on TH1/TH2 Balance in Patients with Digestive Cancers,” Anticancer Research, Vol. 20, No. 6C, 2000, pp. 4707-4711.
 F. Takatsuki, et al., “Improvement of Erythroid Toxicity by Lentinan and Erythropoietin in Mice Treated with Chemotherapeutic Agents,” Experimental Hematology, Vol. 24, No. 3, 1996, pp. 416-422.
 S. Goto, et al., “A Case Report of Recurrent Cervical Cancer Which Responded to a Combination of Biological Therapies,” European Journal of Gynaecological Oncology, Vol. 15, No. 3, 1994, pp. 235-240.
 S. Braedel-Ruoff, “Immunomodulatory Effects of Viscum Album Extracts on Natural Killer Cells: Review of Clinical Trials,” Forsch Komplementmed, Vol. 17, No. 2, 2010, pp. 63-73. doi:10.1159/000288702
 A. Bussing, et al., “Development of Lymphocyte Subsets in Tumor Patients after Subcutaneous Administration of Mistletoe Extracts,” Forsch Komplementarmed, Vol. 6, No. 4, 1999, pp. 196-204. doi:10.1159/000021253
 W. Dohmen, M. Breier and U. Mengs, “Cellular Immunomodulation and Safety of Standardized Aqueous Mis- tletoe Extract PS76A2 in Tumor Patients Treated for 48 Weeks,” Anticancer Research, Vol. 24, No. 2C, 2004, pp. 1231-1237.
 T. Hajto and C. Lanzrein, “Natural Killer and Antibody- Dependent Cell-Mediated Cytotoxicity Activities and Large Granular Lymphocyte Frequencies in Viscum Album-Treated Breast Cancer Patients,” Oncology, Vol. 43, No. 2, 1986, pp. 93-97. doi:10.1159/000226342
 J. Hauer and F. A. Anderer, “Mechanism of Stimulation of Human Natural Killer Cytotoxicity by Arabinogalactan from Larix Occidentalis,” Cancer Immunology, Immunotherapy, Vol. 36, No. 4, 1993, pp. 237-244. doi:10.1007/BF01740905
 G. Maier and H. H. Fiebig, “Absence of Tumor Growth Stimulation in a Panel of 16 Human Tumor Cell Lines by Mistletoe Extracts in Vitro,” Anticancer Drugs, Vol. 13, No. 4, 2002, pp. 373-379. doi:10.1097/00001813-200204000-00006
 C. Guerra, et al., “Control of Mycobacterium Tuberculosis Growth by Activated Natural Killer Cells,” Clinical & Experimental Immunology, Vol. 168, No. 1, 2012, pp. 142-152. doi:10.1111/j.1365-2249.2011.04552.x
 M. Ardolino, et al., “DNAM-1 Ligand Expression on AG-Stimulated T Lymphocytes Is Mediated by ROS-Dependent Activation of DNA-Damage Response: Relevance for NK-T Cell Interaction,” Blood, Vol. 117, No. 18, 2011, pp. 4778-4786. doi:10.1182/blood-2010-08-300954
 I. A. Gamalei, et al., “N-Acetylcysteine-Induced Reduction in Susceptibility of Transformed and Embryonic Cells to Lytic Activity of Natural Killer Cells,” Tsitologiia, Vol. 52, No. 7, 2010, pp. 555-561.
 L. Weiss, et al., “N-Acetylcysteine Mildly Inhibits the Graft-vs.-Leukemia Effect but Not the Lymphokine Activated Cells (LAK) Activity,” Transplant Immunology, Vol. 17, No. 3, 2007, pp. 198-202. doi:10.1016/j.trim.2006.10.005
 N. A. Filatova, K. M. Kirpichnikova and I. A. Gamalei, “N-Acetylcysteine Reduces Transformed 3T3-SV40 Fibroblast Sensitivity to Lysis by Natural Killer Cells,” Tsitologiia, Vol. 48, No. 5, 2006, pp. 438-442.
 J. Zhao and X. J. Liu, “Antioxidative and Immunomodulatory Role of Melatonin, Sodium Selenite, N-Acetyl-L- Cysteine and Quercetin on Human Umbilical Blood,” Pharmazie, Vol. 60, No. 9, 2005, pp. 683-688.
 N. Guayerbas, et al., “A Diet Supplemented with Thiolic Anti-Oxidants Improves Leucocyte Function in Two Strains of Prematurely Ageing Mice,” Clinical and Experimental Pharmacology and Physiology, Vol. 29, No. 11, 2002, pp. 1009-1014. doi:10.1046/j.1440-1681.2002.03758.x
 M. de La Fuente, et al., “The Amount of Thiolic Antioxidant Ingestion Needed to Improve Several Immune Functions Is Higher in Aged than in Adult Mice,” Free Radical Research, Vol. 36, No. 2, 2002, pp. 119-126. doi:10.1080/10715760290006439
 M. Viora, et al., “Redox Imbalance and Immune Functions: Opposite Effects of Oxidized Low-Density Lipoproteins and N-Acetylcysteine,” Immunology, Vol. 104, No. 4, 2001, pp. 431-438. doi:10.1046/j.1365-2567.2001.01334.x
 S. Kojima, et al., “Elevation of Glutathione Induced by Low-Dose Gamma Rays and Its Involvement in Increased Natural Killer Activity,” Radiation Research, Vol. 157, No. 3, 2002, pp. 275-280. doi:10.1667/0033-7587,No.2002)157[0275:EOGIBL]2.0.CO;2
 K. Dobashi, et al., “Regulation of LPS Induced IL-12 Production by IFN-Gamma and IL-4 through Intracellular Glutathione Status in Human Alveolar Macrophages,” Clinical & Experimental Immunology, Vol. 124, No. 2, 2001, pp. 290-296. doi:10.1046/j.1365-2249.2001.01535.x
 R. Breitkreutz, et al., “Improvement of Immune Functions in HIV Infection by Sulfur Supplementation: Two Randomized Trials,” Journal of Molecular Medicine, Vol. 78, No. 1, 2000, pp. 55-62. doi:10.1007/s001090050382
 M. D. Ferrandez, et al., “Effects in Vitro of Several Antioxidants on the Natural Killer Function of Aging Mice,” Experimental Gerontology, Vol. 34, No. 5, 1999, pp. 675-685. doi:10.1016/S0531-5565, No. 99)00009-1
 K. Furuke, et al., “Fas Ligand Induction in Human NK Cells Is Regulated by Redox through a Calcineurin-Nuclear Factors of Activated T Cell-Dependent Pathway,” The Journal of Immunology, Vol. 162, No. 4, 1999, pp. 1988-1993.
 S. Suyuki, et al., “N-Acetylcysteine Improves Cytotoxic Activity of Cirrhotic Rat Liver-Associated Mononuclear Cells,” International Immunology, Vol. 10, No. 10, 1998, pp. 1501-8. doi:10.1093/intimm/10.10.1501
 A. Yamauchi and E. T. Bloom, “Control of Cell Cycle Progression in Human Natural Killer Cells through Redox Regulation of Expression and Phosphorylation of Retinoblastoma Gene Product Protein,” Blood, Vol. 89, No. 11, 1997, pp. 4092-4099.
 T. Chiba, et al., “Fas-Mediated Apoptosis Is Modulated by Intracellular Glutathione in Human T cells,” European Journal of Immunology, Vol. 26, No. 5, 1996, pp. 1164- 1169. doi:10.1002/eji.1830260530
 W. Malorni, et al., “Thiol Supplier N-Acetylcysteine Enhances Conjugate Formation between Natural Killer Cells and K562 or U937 Targets but Increases the Lytic Function Only Against the Latter,” Immunology Letters, 1994, Vol. 43, No. 3, pp. 209-214. doi:10.1016/0165-2478, No. 94)90225-9
 C. Y. Yim, et al., “Use of N-Acetyl Cysteine to Increase Intracellular Glutathione During the Induction of Antitumor Responses by IL-2,” The Journal of Immunology, Vol. 152, No. 12, 1994, pp. 5796-805.
 R. Di Franco, et al., “Skin Toxicity from External Beam Radiation Therapy in Breast Cancer Patients: Protective Effects of Resveratrol, Lycopene, Vitamin C and Anthocianin (Ixor?),” Radiation Oncology, Vol. 7, 2012, pp. 12. doi:10.1186/1748-717X-7-12
 J. H. Kim, C. Chen and A. N. Tony Kong, “Resveratrol Inhibits Genistein-Induced Multi-Drug Resistance Protein 2 (MRP2) Expression in HepG2 Cells,” Archives of Biochemistry and Biophysics, Vol. 512, No. 2, 2011, pp. 160-1666. doi:10.1016/j.abb.2011.06.004
 Y. Hiroto, et al., “Resveratrol, a Phytoestrogen Found in Red Wine, Down-Regulates Protein S Expression in HepG2 Cells,” Thrombosis Research, Vol. 127, No. 1, 2011, pp. e1-e7. doi:10.1016/j.thromres.2010.09.010
 I. Muqbil, et al., “Old Wine in a New Bottle: The Warburg Effect and Anticancer Mechanisms of Resveratrol. Current Pharmaceutical Design,” Vol. 18, No. 12, 2012, pp. 1645-1654. doi:10.2174/138161212799958567
 X. Xu, et al., “Resveratrol Attenuates Doxorubicin-Induced Cardiomyocyte Death via Inhibition of P70 S6 Kinase 1-Mediated Autophagy,” Journal of Pharmacol- ogy and Experimental Therapeutics, Vol. 341, No. 1, 2012, pp. 183-195. doi:10.1124/jpet.111.189589
 W. Mo, et al., “Resveratrol Inhibits Proliferation and Induces Apoptosis through the Hedgehog Signaling Pathway in Pancreatic Cancer Cell,” Pancreatology, Vol. 11, No. 6, 2011, pp. 601-609. doi:10.1159/000333542
 J. Ryu, et al., “Resveratrol Reduces TNF-Alpha-Induced U373MG Human Glioma Cell Invasion through Regulating NF-KappaB Activation and uPA/uPAR Expression,” Anticancer Research, Vol. 31, No. 12, 2011, pp. 4223- 4230.
 C. C. Lu and J. K. Chen, “Resveratrol Enhances Perforin Expression and NK Cell Cytotoxicity through NKG2D- Dependent Pathways,” Journal of Cellular Physiology, Vol. 223, No. 2, 2010, pp. 343-351.
 C. Alvarado, et al., “Improvement of Leukocyte Functions in Young Prematurely Aging Mice after a 5-Week Ingestion of a Diet Supplemented with Biscuits Enriched in Antioxidants,” Antioxidants & Redox Signaling, Vol. 7, No. 9-10, 2005, pp. 1203-1210. doi:10.1089/ars.2005.7.1203
 M. Enqvist, et al., “Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells,” The Journal of Immunology, Vol. 187, No. 7, 2011, pp. 3546-3554. doi:10.4049/jimmunol.1100610
 W. C. Hawkes, “A. Hwang, and Z. Alkan, The Effect of Selenium Supplementation on DTH Skin Responses in Healthy North American Men,” Journal of Trace Elements in Medicine & Biology, Vol. 23, No. 4, 2009, pp. 272-280. doi:10.1016/j.jtemb.2009.04.002
 X. Chen, et al., “Effect of Excessive Iodine on Immune Function of Lymphocytes and Intervention with Selenium,” Journal of Huazhong University of Science and Technology-Medical Sciences, Vol. 27, No. 4, 2007, pp. 422-425. doi:10.1007/s11596-007-0418-1
 C. Klein, et al., “From Food to Nutritional Support to Specific Nutraceuticals: A Journey across Time in the Treatment of Disease,” Journal of Gastroenterology, Vol. 35, No. Suppl. 12, 2000, pp. 1-6.
 J. Tamura, et al., “Immunomodulation by Vitamin B12: Augmentation of CD8+ T Lymphocytes and Natural Killer (NK) Cell Activity in Vitamin B12-Deficient Patients by Methyl-B12 Treatment,” Clinical & Experimental Im- munology, Vol. 116, No. 1, 1999, pp. 28-32. doi:10.1046/j.1365-2249.1999.00870.x
 F. Brivio, et al., “Preoperative Interleukin-2 Subcutaneous Immunotherapy May Prolong the Survival Time in Advanced Colorectal Cancer Patients,” Oncology, Vol. 53, No. 4, 1996, pp. 263-268. doi:10.1159/000227571
 P. H. Nichols, et al., “The Effect of 5-Fluorouracil and Alpha Interferon and 5-Fluorouracil and Leucovorin on Cellular Anti-Tumour Immune Responses in Patients with Advanced Colorectal Cancer,” British Journal of Cancer, Vol. 70, No. 5, 1994, pp. 946-949. doi:10.1038/bjc.1994.426
 M. K. Baum, et al., “Association of Vitamin B6 Status with Parameters of Immune Function in Early HIV-1 Infection,” Journal of Acquired Immune Deficiency Syndromes, Vol. 4, No. 11, 1991, pp. 1122-1132.
 C. Ha, L. T. Miller and N. I. Kerkvliet, “The Effect of Vitamin B6 Deficiency on Cytotoxic Immune Responses of T Cells, Antibodies, and Natural Killer Cells, and Phagocytosis by Macrophages,” Cellular Immunology, Vol. 85, No. 2, 1984, pp. 318-329. doi:10.1016/0008-8749, No. 84)90246-6
 B. Atasever, et al., “In Vitro Effects of Vitamin C and Selenium on NK Activity of Patients with Beta-Thalassemia Major,” Journal of Pediatric Hematology/On- cology, Vol. 23, No. 3, 2006, pp. 187-197. doi:10.1080/08880010500506420
 M. De la Fuente, A. Hernanz and M. C. Vallejo, “The Immune System in the Oxidative Stress Conditions of Aging and Hypertension: Favorable Effects of Antioxidants and Physical Exercise,” Antioxidants & Redox Signaling, Vol. 7, No. 9-10, 2005, pp. 1356-1366. doi:10.1089/ars.2005.7.1356
 G. Heuser and A. Vojdani, “Enhancement of Natural Killer Cell Activity and T and B Cell Function by Buffered Vitamin C in Patients Exposed to Toxic Chemicals: The Role of Protein Kinase-C,” Immunopharmacol and Immunotoxicol, Vol. 19, No. 3, 1997, pp. 291-312. doi:10.3109/08923979709046977
 E. W. Petersen, et al., “Effect of Vitamin Supplementation on Cytokine Response and on Muscle Damage after Strenuous Exercise,” American Journal of Physiology— Cell Physiology, Vol. 280, No. 6, 2001, pp. C1570- C1575.
 D. See, S. Mason and R. Roshan, “Increased Tumor Necrosis Factor Alpha (TNF-Alpha) and Natural Killer Cell (NK) Function Using an Integrative Approach in Late Stage Cancers,” Immunological Investigations, Vol. 31, No. 2, 2002, pp. 137-153. doi:10.1081/IMM-120004804
 K. Suresh and D. M. Vasudevan, “Augmentation of Murine Natural Killer Cell and Antibody Dependent Cellular Cytotoxicity Activities by Phyllanthus Emblica, a New Immunomodulator,” Journal of Ethnopharmacology, Vol. 44, No. 1, 1994, pp. 55-60. doi:10.1016/0378-8741, No. 94)90099-X
 I. K. Toliopoulos, et al., “Inhibition of Platelet Aggregation and Immunomodulation of NK Lymphocytes by Administration of Ascorbic Acid,” Indian Journal of Experimental Biology, Vol. 49, No. 12, 2011, pp. 904-908.
 E. S. Wintergerst, S. Maggini and D. H. Hornig, “Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical Conditions,” Annals of Nutrition and Metabolism, Vol. 50, No. 2, 2006, pp. 85-94. doi:10.1159/000090495
 A. E. El-Shazly and P. P. Lefebvre, “Modulation of NK Cell Autocrine-Induced Eosinophil Chemotaxis by Interleukin-15 and Vitamin D3: A Possible NK-Eosinophil Crosstalk via IL-8 in the Pathophysiology of Allergic Rhinitis,” Mediators of Inflammation, Vol. 2011, 2011, Article ID: 373589.
 J. H. Ooi, J. Chen, and M. T. Cantorna, “Vitamin D Regulation of Immune Function in the Gut: Why Do T Cells Have Vitamin D Receptors?” Molecular Aspects of Medicine, Vol. 33, No. 1, 2012, pp. 77-82. doi:10.1016/j.mam.2011.10.014
 A. Rohner, et al., “Differentiation-Promoting Drugs Up- Regulate NKG2D Ligand Expression and Enhance the Susceptibility of Acute Myeloid Leukemia Cells to Natural Killer Cell-Mediated Lysis,” Leukemia Research, Vol. 31, No. 10, 2007, pp. 1393-1402. doi:10.1016/j.leukres.2007.02.020
 X. Wang, N. M. Ponzio and G. PP. Studzinski, “Long-Term Exposure of HL60 Cells to 1,25-DihydroxyVitamin D3 Reduces Their Tumorigenicity: A Model for Cancer Chemoprevention,” Proceedings of the Society for Experimental Biology and Medicine, 1997, Vol. 215, No. 4, pp. 399-404.
 S. Yu and M. T. Cantorna, “Epigenetic Reduction in Invariant NKT Cells Following in Utero Vitamin D Deficiency in Mice. The Journal of Immunology, Vol. 186, No. 3, 2011, pp. 1384-1390. doi:10.4049/jimmunol.1002545
 M. G. Hanson, et al., “A Short-Term Dietary Supplementation with High Doses of Vitamin E Increases NK Cell Cytolytic Activity in Advanced Colorectal Cancer Patients,” Cancer Immunology, Immunotherapy, Vol. 56, No. 7, 2007, pp. 973-984. doi:10.1007/s00262-006-0261-4
 D. Bunout, et al., “Effects of a Nutritional Supplement on the Immune Response and Cytokine Production in Free- Living Chilean Elderly,” Journal of Parenteral and Enteral Nutrition, Vol. 28, No. 5, 2004, pp. 348-354. doi:10.1177/0148607104028005348
 M. A. Beck, D. Williams-Toone and O. A. Levander, “Coxsackievirus B3-Resistant Mice Become Susceptible in Se/Vitamin E Deficiency,” Free Radical Biology & Medicine, Vol. 34, No. 10, 2003, pp. 1263-1270. doi:10.1016/S0891-5849, No. 03)00101-1
 C. Y. Lee and J. M. Wan, “Immunoregulatory and Antioxidant Performance of Alpha-Tocopherol and Selenium on Human Lymphocytes,” Biological Trace Element Rese, Vol. 86, No. 2, 2002, pp. 123-136. doi:10.1385/BTER:86:2:123
 C. Alvarado, et al., “Dietary Supplementation with Antioxidants Improves Functions and Decreases Oxidative Stress of Leukocytes from Prematurely Aging Mice,” Nutrition, Vol. 22, No. 7-8, 2006, pp. 767-777. doi:10.1016/j.nut.2006.05.007
 Y. K. Jeon, et al., “Expression of the Promyelocytic Leukemia Zinc-Finger in T-Lymphoblastic Lymphoma and Leukemia Has Strong Implications for Their Cellular Origin and Greater Association with Initial Bone Marrow Involvement,” Modern Pathology Advance Online Publication, 2012. doi:10.1038/modpathol.2012.82
 PP. Pereira and L. Boucontet, “Innate NKTγδ and NKTαβ Cells Exert Similar Functions and Compete for a Thymic Niche,” European Journal of Immunology, 2012, Vol. 42, No. 5, pp. 1272-1281. doi:10.1002/eji.201142109
 J. Yamashita, et al., “Murine Schnurri-2 Controls Natural Killer Cell Function and Lymphoma Development,” Leukemia & Lymphoma, Vol. 53, No. 3, 2012, pp. 479- 486. doi:10.3109/10428194.2011.625099
 S. Y. Thomas, et al., “PLZF Induces an Intravascular Surveillance Program Mediated by Long-Lived LFA-1- ICAM-1 Interactions,” The Journal of Experimental Medicine, Vol. 208, No. 6, 2011, pp. 1179-1188. doi:10.1084/jem.20102630
 E. Mocchegiani, et al., “NK and NKT Cells in Aging and Longevity: Role of Zinc and Metallothioneins,” Journal of Clinical Immunology, Vol. 29, No. 4, 2009, pp. 416- 425. doi:10.1007/s10875-009-9298-4
 M. Muzzioli, et al., “Zinc Improves the Development of Human CD34+ Cell Progenitors towards Natural Killer Cells and Induces the Expression of GATA-3 Transcription Factor,” The International Journal of Biochemistry & Cell Biology, Vol. 39, No. 5, 2007, pp. 955-965. doi:10.1016/j.biocel.2007.01.011
 G. Cocchi, et al., “Immunological Patterns in Young Children with Down syndrome: Is There a Temporal Trend?” Acta Paediatrica, Vol. 96, No. 10, 2007, pp. 1479-1482. doi:10.1111/j.1651-2227.2007.00459.x
 E. Mariani, et al., “Effect of Zinc Supplementation on Plasma IL-6 and MCP-1 Production and NK Cell Function in Healthy Elderly: Interactive Influence of +647 MT1a and ?174 IL-6 Polymorphic Alleles,” Experimen- tal Gerontology, Vol. 43, No. 5, 2008, pp. 462-471. doi:10.1016/j.exger.2007.12.003
 V. Brazao, et al., “Zinc Supplementation Increases Resistance to Experimental Infection by Trypanosoma Cruzi,” Veterinary Parasitology, Vol. 154, No. 1-2, 2008, pp. 32- 37. doi:10.1016/j.vetpar.2008.02.015
 C. H. Metz, et al., “T-Helper Type 1 Cytokine Release Is Enhanced by in Vitro Zinc Supplementation Due to Increased Natural Killer Cells,” Nutrition, Vol. 23, No. 2, 2007, pp. 157-163. doi:10.1016/j.nut.2006.10.007
 O. DelaRosa, et al., “Immunological Biomarkers of Aging in Man: Changes in both Innate and Adaptive Immunity Are Associated with Health and Longevity,” Bio- gerontology, Vol. 7, No. 5-6, 2006, pp. 471-481. doi:10.1007/s10522-006-9062-6
 C. F. Hodkinson, et al., “Zinc Status and Age-Related Changes in Peripheral Blood Leukocyte Subpopulations in Healthy Men and Women Aged 55-70 Y: the ZENITH Study,” European Journal of Clinical Nutrition, Vol. 59, No. Suppl. 2, 2005, pp. S63-S67. doi:10.1038/sj.ejcn.1602301