ABSTRACT Although there have been many reports on the toxicity of tobacco smoke, fewer studies have reported the relationship between the smoke and carcinogenesis of head-and-neck cancers. It is assumed that direct stimulations due to tobacco smoke, such as chemical and mechanical stimulations, strongly influence the epithelium of the nasal cavity, paranasal sinuses, pharynx, and larynx. We investigated the influence of active and passive cigarette smoking on head-and-neck cancers. The subjects were 283 head-and-neck cancer patients examined at the otolaryngology department of Showa University Northern Yokohama Hospital in a 9-year and 2-month period from April 2001 to June 2010, in whom the presence or absence of active and passive cigarette smoking could be confirmed in detail. The active and passive smoking rates and the Brinkman index were retrospectively investigated according to the primary cancer site, gender, and histopathological classification. The active and passive smoking rates were high (about 90%) in patients with hypopharyngeal, laryngeal, and cervical esophageal cancers, and the Brinkman index was high in all. Squamous cell carcinoma (SCC) patients accounted for a high ratio of the head-and-neck cancer patients, and the active and passive smoking rates were significantly higher in SCC than in non-squamous cell carcinoma (non-SCC) patients (p < 0.0003). The active and passive smoking rates and the Brinkman index were high in patients with head-and-neck cancers in regions receiving strong direct stimulation from tobacco smoke, and the Brinkman index was also high in these patients, suggesting that carcinogenesis of head-and-neck cancers is strongly influenced by direct tobacco smoke stimulation.
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Kushihashi, Y. , Kadokura, Y. , Takiguchi, S. , Kyo, Y. , Yamada, Y. , Shino, M. , Kano, M. and Suzaki, H. (2012) Association between head-and-neck cancers and active and passive cigarette smoking. Health, 4, 619-624. doi: 10.4236/health.2012.49097.
 Burnett, K. F. and Young, P. C. (1999) Ask, advice, assist: Pediatricians and passive smoke exposure. Clinical Pediatrics, 38, 339-345. doi:10.1177/000992289903800604
 Reardon, J. Z. (2007) Environmental tobacco smoke: Respiratory and other health effects. Clinics in Chest Medicine, 28, 559-573. doi:10.1016/j.ccm.2007.06.006
 Kurahashi, N., Inoue, M., Liu, Y., Iwasaki, M., Sasazaki, S., Sobue, T. and Tsugane, S. (2008) Passive smoking and lung cancer in Japanese non-smoking women: Prospective study. International Journal of Cancer, 122, 653-657.
 Hoffmann, D. and Hoffmann, I. (2001) The changing cigarette chemical studies and bioassay. Smoking and Tobacco Control Monograph, 13, 159-192.
 Dyer, O. (2002) Harm from smoking is even greater than previously thought. British Medical Journal, 324, 1544.
 Niranjan Goud, S. (1999) Inhibition of natural killer cell activity in mice treated with Tobacco specific carcinogen NNK. Journal of toxicology and Environmental Health, 56, 131-144.
 Levitz, J. S., Bradley, T. P. and Golden, A. L. (2004) Overview of smoking and all cancers. The Medical Clinics of North America, 88, 1655-1675.
 Hirayama, T. (1983) Passive smoking and lung cancer: Consistency of association. Lancet, 2, 1425-1426.
 Lafuente, A., Pujolb, F., Carreteroc, P., Villad, J. P. and Cuchi, A. (1993) Human glutathione S-transferase
μ(GSTμ) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers. Cancer Letters, 68, 49-54.
 Leea, C.-T., Kanga, K. H., Koha, Y., Changa, J., Chunga, H. S. Sue, Parkb, K., Yoob, K.-Y. and Songa, J. S. (2000) Characteristics of lung cancer in Korea, 1997. Lung Cancer, 30, 15-22. doi:10.1016/S0169-5002(00)00126-4
 Renstrup, D., Smulow, J. and Glickman, I. (1961) Carcinogenesis and mechanical irritation in the cheek of the hamster. Journal of Dental Research, 40, 649.
 Oone, M., Satou, T. and Sekikawa, K. (1990) Developmental process of early cancer of the tongue. The observation by oral administration method of carcinogendissolved potable water. Dental Outlook, 76, 889-893.
 Sato, T. (1995) A study on effect of mechanical irritation in development and progression of tongue cancer. Kokubyo Gakkai Zasshi, 62, 532-550.
 Fujiki, H. and Suganuma, M. (1994) Tumor necrosis factor-α new tumor promoter, engendered by biochemical studies of okadaic acid. The Journal of Biochemistry, 115, 1-5.
 Nomura, T., Shibahara, T., Noma, H., et al. (1998) A study of smoking and drinking habits as carcinogens in the development of oral cancer. Head and Neck Cancer, 24, 83-89.