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 JBPC  Vol.3 No.3 , August 2012
Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro
Abstract: Zonisamide (ZNS), a commonly used anticonvulsant, scavenged hydroxyl radicals at a clinically relevant concentration. Reactants of ZNS with hydrogen peroxide and with hydrogen peroxide plus UV irradiation, yielding hydroxyl radicals, were analyzed by the LC/MS technique. Many small fragments were found in the both reactions, suggesting that ZNS was decomposed not only by hydroxyl radicals but also by hydrogen peroxide. Furthermore, mass-fragment-grams showed that m/z: 213 (ZNS itself) was decreased markedly and m/z: 118 (may be a decomposed product by ring cleavage of ZNS) was detected specifically by treatment with hydroxyl radical. These data suggested that ZNS may react directly with free radicals.
Cite this paper: Tanaka, K. , Nanba, T. , Furubayashi, T. , Noda, Y. , James Willmore, L. and Mori, A. (2012) Molecular basis of scavenging effect of zonisamide on hydroxyl radical in vitro. Journal of Biophysical Chemistry, 3, 256-258. doi: 10.4236/jbpc.2012.33030.
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