ABB  Vol.3 No.4 A , August 2012
Influence of periodontitis and nonsurgical periodontal intervention on atherosclerosis diseases
ABSTRACT
Objective: Periodontitis and atherosclerosis diseases are chronic inflammatory disorders which are highly prevalent in populations. Nonsurgical periodontal intervention belongs to the initial therapy strategy to periodontal diseases. Periodontal pathogen can enter into blood stream through the ulceration epithelial resulting in bacteraemia when periodontitis is severe. The objective is to investigate the relationship between periodontitis and atherosclerosis diseases, and the influence of nonsurgical periodontal intervention on atheroma and atherosclerosis diseases. Methods: This study reviewed and analyzed the papers which published in the world associated with periodontitis or periodontal intervention on atherosclerosis diseases. Results: Periodontitis and periodontal infectious are important risk factors for atherosclerotic diseases. Much evidence has proved the durative severe periodontitis can result in bacteraemia and systemic inflammation, elevated C-response protein in serum, gingival microcirculation changed, periodontal microorganism reproduced, and endothelial dys-function and endocarditis. Nonsurgical periodontal intervention can remove the pathogenesis bacteria and calculus to recover periodontal health. Effective periodontal therapy can reduce bacteraemia and stop the hurt to vessels. Nonsurgical periodontal therapy may interfere periodontal bacteria, inhibit inflammation response and C-response protein, improving gingival microcirculation and vessel epithelial function to prevent atherosclerosis. Conclusion: Nonsurgical periodontal intervention can improve or decrease the rate of atherosclerotic disease by interfere the severe periodontitis. The detailed mechanism of periodontal intervention on atheroma and atherosclerotic disease is still need to be explored.

Cite this paper
Chen, T. , Wang, S. , Liu, G. , Zhang, X. , Tang, D. and Wu, Z. (2012) Influence of periodontitis and nonsurgical periodontal intervention on atherosclerosis diseases. Advances in Bioscience and Biotechnology, 3, 531-537. doi: 10.4236/abb.2012.324070.
References
[1]   Mattila, K.J., Asikainen, S., Wolf, J., Jousimies-Somer, H., Valtonen, V., Nieminen, M.( 2000) Age, dental infections, and coronary heart disease. J Dent Res,79,756–760.

[2]   Ouyang, X.Y., Xiao, W.M., Chu, Y., Zhou, S.Y. (2011) Influence of periodontal intervention therapy on risk of cardiovascular disease. Periodontology 2000,56, 227-257.

[3]   Geerts, S.O., Legrand, V., Charpentier, J., Albert, A., Rompen, E.H. (2004) Further evidence of the association between periodontal conditions and coronary artery disease. J Periodontol, 75,1274-1280.

[4]   Andriankaja, O.M., Genco, R.J., Dorn, J., Dmochowski, J., Hovey, K., Falkner, K.L., Trevisan, M. (2007) Periodontal disease and risk of myocardial infarction: the role of gender and smoking. Eur J Epidemiol, 22, 699-705.

[5]   Guntheroth, W.G.(1984) How important are dental procedures as a cause of infective endocarditis? American Journal of Cardiology, 54, 797–801.

[6]   Bahekar, A.A., Singh, S., Saha, S., Molnar, J., Arora, R. (2007) The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J, 154,830–837.

[7]   Brodala, N.M.E., Bellinger, D.A., Damrongsri, D., Offenbacher, S., Beck, J., Madianos, P., Sotres, D., Chang, Y.L., Koch, G., Nichols, T.C. (2005) Porphyromonas gingivalis bacteremia induces coronary and aortic atherosclerosis in nor mocholesterolemic and hypercholesterolemic pigs. Arterioscler Thromb Vasc Biol, 25, 1446-1451.

[8]   Ioannidou, E., Malekzadeh, T., Dongari-Bagtzoglou, A. (2006) Effect of periodontal treatment on serum C-reactive protein levels: a systematic review and meta-analysis. J Periodontol, 77, 1635-1642.

[9]   Chen, T.L., Zhou, Y.J., Wu, Z.F., Yang, L.J., Jin, Y. (1993) The distribution of prostaglandin E2 in gingival of periodontal diseases. J Practical Stomatology,9(2),73-75.

[10]   Chen, T.L., Zhou, Y.J., Wu, Z.F., Jin, Y. (1995) Quantitative analysis of prostaglandin E2 in gingival of patients with periodontal diseases by radioimmunoassay and immunohistochemistry. Chin J Conserv Dent, 5(3),141-143

[11]   Chen, T.L., Song, P.Z. (1996) The clinical observation of the effects of indomethacin on gingivitis in the seamen. Chin J Naut Med, 3(2),104-106 .

[12]   Chen, T.L., Zhou, Y.J., Wu, Z.F., Song, P.Z., Xu, Z.C. (1996) The inhibit effects of indomethacin on experimental periodontitis of guinea pigs, morphological observation. J Stomatol,16(1),9-11.

[13]   Chen, T.L., Zhou, Y.J., Wu, Z.F. (1996) The inhibit effects of indomethacin on prostaglandin E2 in gingival and alveolar bone. J Modern Stomatol,10(2),75-77.

[14]   Ewald, C., Kuhn, S. & Kalff, R. (2006) Pyogenic infections of the central nervous system secondary to dental affections – a report of six cases. Neurosurgery Reviews, 29,163–166; discussion 166–167.

[15]   Suzuki, J. B. & Delisle, A. L. (1984) Pulmonary actinomycosis of periodontal origin. Journal of Periodontology, 55, 581–584.

[16]   Abeywardena, M.Y., Leifert, W.R., Warnes, K.E., Varghese, J.N., Head, R.J.(2009) Cardiovascular biology of interleukin-6. Curr Pharm Des, 15(15), 1809-1821.

[17]   Ridker, P.M., Rifai, N., Stampfer, M.J., Hennekens, C.H. (2000) Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation, 101,1767–1772.

[18]   Loos, B.G., Craandijk, J., Hoek, F.J., Wertheimvan D.P.M., van der Velden, U.(2000) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol, 71, 1528–1534.

[19]   Higashi, Y., Goto, C., Hidaka, T., Soga, J., Nakamura, S., Fujii, Y., Hata, T., Idei, N., Fujimura, N., Chayama, K., Kihara, Y., Taguchi, A. (2009) Oral infection–inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease. Atherosclerosis, 206, 604–610.

[20]   Czerniuk, M.R., Gorska, R., Filipiak, K.J., Opolski, G. (2004) Inflammatory response to acute coronary syndrome in patients with coexistent periodontal disease. J Periodontol, 75, 1020–1026.

[21]   Buhlin, K., Hultin, M., Norderyd, O.(2009) Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis. Atherosclerosis, 206, 518-522.

[22]   Yamazaki, K., Honda, T., Oda, T., Ueki-Maruyama, K., Nakajima, T., Yoshie, H., Seymour, G.J.(2005) Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. J Periodontal Res, 40, 53–58.

[23]   Higashi, Y., Goto, C., Hidaka, T., Soga, J., Nakamura, S., Fujii, Y., Hata, T., Idei, N., Fujimura, N., Chayama, K., Kihara, Y., Taguchi, A. (2009) Oral infection–inflammatory pathway, periodontitis, is a risk factor for endothelial dysfunction in patients with coronary artery disease. Atherosclerosis, 206, 604–610.

[24]   Iwamoto, Y., Nishimura, F., Soga, Y., Takeuchi, K., Kurihara, M., Takashiba, S., Murayama, Y.(2003) Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponection levels in patients with chronic periodontitis. J Periodontol, 74,1231–1236.

[25]   D’Aiuto, F., Parkar, M., Nibali, L., Suvan, J., Lessem, J. & Tonetti, M.S. (2006)Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. American Heart J, 151, 977–984.

[26]   Iwai, T. (2009) Periodontal bacteremia and various vascular diseases. J Periodontol Res, 44,689–694.

[27]   Haraszthy, V.I., Zambon, J.J., Trevisan, M., Zeid, M., Genco, R.J. (2000) Identification of periodontal pathogens in atheromatous plaques. J Periodontol, 71, 1554-1560.

[28]   Gibson, F.C., Yumoto, H., Takahashi, Y. (2006) Innate immune signaling and Porphyromonas gingivalis-accelerated atherosclerosis. J Dent Res, 85(2 ), 106-121

[29]   Gaetti-Jardim, E., Marcelino, S.L., Feitosa, A.C.R., Romito, G.A., Avila-Campos, M.J.(2009) Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. J Med Microbiol, 58, 1568-1575.

[30]   Mattila, K., Nieminen, M., Valtonen, V., Rasi, V., Kesaniemi, Y., Syrjala, S., Jungul, P., Isoluoma, M., Hietaniemi, K., Jokinen, M., Huttunen, J. (1989) Association between dental health and acute myocardial infarction. Br Med J, 298, 779–782.

[31]   Chen, T.L., Lin, S.L., Zhou, Y.J., Yao, X.G., Liu, J.C.,Wu, Z.F., Wang, G. (2006)The effects of periodontal scaling on microorganism in periodontal pocket and gingival crevicular fluid in patients with periodontitis. J Pract Stomatol, 22(4),547-549.

[32]   Black, S., Kushner, I., Samols, D.(2004) C-reactive protein. J Biol Chem, 279,48487–48490.

[33]   Ridker, P.M., Hennekens, C.H., Buring, J.E., Rifai, N. (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med, 342, 836–843.

[34]   Sun, X.J., Meng, H.X., Shi, D., Xu, L., Zhang, L., Chen, Z.B., Feng, X.H., Lu, R.F., Ren, X.Y. (2009) Elevation of C-reactive protein and interleukin-6 in plasma of patients with aggressive periodontitis. J Periodontal Res, 44, 311-316.

[35]   Paraskevas, S., Huizinga, J.D., Loos, B.G. (2008) A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol, 35, 277-290.

[36]   Tuter. G., Kurtis, B., Serdar, M. (2007) Evaluation of gingival crevicular fluid and serum levels of high-sensitivity C-reactive protein in chronic periodontitis patients with or without coronary artery disease. J Periodontol , 78, 2319–2324.

[37]   Offenbacher, S., Beck, J.D., Moss, K.(2009) Results from the periodontitis and vascular events (PAVE) study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol, 80, 190-201.

[38]   Acharya, A., Bhavsar, N., Jadav, B., Parikh, H. (2010) Cardioprotective: effect of periodontal therapy in metabolic syndrome: a pilot study in Indian subjects. Metab Syndr Relat Disord, 8,1–7.

[39]   Izumi, Y., Nagasawa, T., Umeda, M.(2009) Periodontitis and cardiovascular diseases: the link and relevant mechanisms. Jpn Dent Sci Rev, 45,98–108.

[40]   Herzberg, M.C., Weyer, M.W. (1998) Dental plaque, platelets, and cardiovascular diseases. Ann Periodontol, 3,151-160.

[41]   Amar, S., Gokce, N., Morgan, S., Loukideli, M., Van Dyke, T.E. & Vita, J.A.(2003) Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arteriosclerosis Thrombosis Vascular Biology, 23, 1245–1249.

[42]   Elter, J.R., Hinderlitwer, A.L., Offenbacher, S.,Beck, J.D., Caughey, M., Brodala, N.,Madianos, P.N. (2006)The effects of periodontal therapy on vascular endothelial function:a pilot trial. Am Heart J, 151,47.e1-47.e6.

[43]   Tonetti, M.S., D Aiuto, F., Nibali, L., Danold, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A.D.,Vallance, P., Deanfield, J.(2007)Treatment of periodontitis and endothelial function. N Engl J Med,356,911-920.

[44]   Seinost, G., Winmmer, G.,Skerget, M., Thaller, E., Brodmann, M., Gasser, R., Bratschko, R.O.,Pilger, E.(2005) Periodontal treatment improves endothelial dysfunction in patients with severe peridontitis. Am Heart J, 149, 1050-1054.

[45]   Chen, T.L., Lin, S.L., Lu, Y.L., Liu, J.C., Liu, G.Q. (1999) The blood flow, blood current velocity and blood concentration in gingival of the patients with periodontal diseases. J Pract Stomatol, 15(1),33-34.

[46]   Chen, T.L., Lin, S.L.,Zhou, Y.J., Liu, J.C.,Wu, Z.F. (2007) The biological effects of periodontal scaling and root planning on gingival microcirculation. J Modern Stomatol, 21(1),4-6.

[47]   Chen,T.L.,Lin,S.L.,Liu, G.Q., Wang, W.X., Yu, J.W.,Liu, J.C., Zhao, H.J., Ji, Q.J.(2007) Effects of periodontal scaling on gingival blood flow volume and gingivitis in marines.Chin J Naut Med &Hyperbar Med, 14(3), 155-157.

 
 
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