Effect of propofol on local field potential in rat prefrontal cortex during working memory task
Affiliation(s)
School of Biomedical Engineering, Tianjin Medical University, Tianjin, China. Department of Anesthesiology, Tianjin General Hospital, Tianjin Medical University, Tianjin, China.
School of Biomedical Engineering, Tianjin Medical University, Tianjin, China. Department of Anesthesiology, Tianjin General Hospital, Tianjin Medical University, Tianjin, China.
ABSTRACT
Propofol may produce memory impairment during anesthesia procedure. Local field potentials (LFPs) are used with increasing frequency in recent years to link neural activity to perception and cognition. In this study, effect of propofol on LFPs in rat’s prefrontal cortex during working memory task was evaluated. Young (approximately 3 month) male Sprague-Dawley rats were divided into two group: propofol rats and control rats. Propofol rats received propofol at 0.9 mg/Kg·min intravenously for 2 h. After 12 h, LFPs of all rats were measured simultaneously from multiple electrodes placed in prefrontal cortex while rats were performing a working memory task in Y-maze. LFPs instantaneous phase were obtained by applying Hilbert transform, and cross-correlation coherence of LFPs was calculated. The results indicate that propofol decreased the correct rate and crosscorrelation coherence of LFPs on the first two days (p < 0.05), but had no effect on the third day (p > 0.05). Our results suggest that propofol can impair cross-correlation coherence of LFPs in the first two days, but not long time.
Propofol may produce memory impairment during anesthesia procedure. Local field potentials (LFPs) are used with increasing frequency in recent years to link neural activity to perception and cognition. In this study, effect of propofol on LFPs in rat’s prefrontal cortex during working memory task was evaluated. Young (approximately 3 month) male Sprague-Dawley rats were divided into two group: propofol rats and control rats. Propofol rats received propofol at 0.9 mg/Kg·min intravenously for 2 h. After 12 h, LFPs of all rats were measured simultaneously from multiple electrodes placed in prefrontal cortex while rats were performing a working memory task in Y-maze. LFPs instantaneous phase were obtained by applying Hilbert transform, and cross-correlation coherence of LFPs was calculated. The results indicate that propofol decreased the correct rate and crosscorrelation coherence of LFPs on the first two days (p < 0.05), but had no effect on the third day (p > 0.05). Our results suggest that propofol can impair cross-correlation coherence of LFPs in the first two days, but not long time.
Cite this paper
Xu, X. , Wang, G. , Zhai, W. , Bai, W. , Liu, T. and Tian, X. (2012) Effect of propofol on local field potential in rat prefrontal cortex during working memory task. World Journal of Neuroscience, 2, 166-171. doi: 10.4236/wjns.2012.23026.
Xu, X. , Wang, G. , Zhai, W. , Bai, W. , Liu, T. and Tian, X. (2012) Effect of propofol on local field potential in rat prefrontal cortex during working memory task. World Journal of Neuroscience, 2, 166-171. doi: 10.4236/wjns.2012.23026.
References
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(2005) Dynamically modulated spike correlation in monkey inferior temporal cortex depending on the feature configuration within a whole object. Journal of Neuroscience, 25, 10299-10307. doi:10.1523/JNEUROSCI.3036-05.2005
[1] Jones, C., Griffiths, R.D. and Humphris, G. (2000) Disturbed memory and amnesia related to intensive care. Memory, 8, 79-94. [2] Barr, G., Anderson, R.E., Owall, A. and Jakobsson, J.G. (2001) Being awake intermittently during propofol-induced hypnosis: A study of BIS, explicit and implicit memory. Acta Anaesthesiologica Scandinavica, 45, 834-838. [3] Semba, K., Adachi, N. and Arai, T. (2005) Facilitation of serotonergic activity and amnesia in rats caused by intravenous anesthetics. Anesthesiology, 102, 616-623. [4] Baeg, E.H., Kim, Y.B., Kim, H.T., Mook-Jung, I. and Jung, M.W. (2001) Fast spiking and regular spiking neural correlates of fear conditioning in the medial prefrontal cortex of the rat. Cerebral Cortex, 11, 441-451. doi:10.1093/cercor/11.5.441 [5] Lansner, A. (2009) Associative memory models: From the cell-assembly theory to biophysically detailed cortex simulations. Trends in Neurosciences, 32, 178-186. doi:10.1016/j.tins.2008.12.002 [6] Fuster, J.M. (1997) The prefrontal cortex. 3rd Edition, Raven Press, New York. [7] Funahashi, S., Bruce, C.J. and Goldman-Rakic, P.S. (1989) Mnemonic coding of visual space in the monkey’s dorsolateral prefrontal cortex. Journal of Neurophysiology, 61, 331-349. [8] Miller, E.K., Erickson, C.A. and Desimone, R. (1996) Neural mechanisms of visual working memory in prefrontal cortex of the macaque. Journal of Neuroscience, 16, 5154-5167. [9] Funahashi, S. (2001) Neuronal mechanisms of executive control by the prefrontal cortex. Neuroscience Research, 39, 147-165. doi:10.1016/S0168-0102(00)00224-8 [10] Miller, E.K. and Cohen, J.D. (2001) An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167-202. doi:10.1146/annurev.neuro.24.1.167 [11] Wang, X.J. (2001) Synaptic reverberation underlying mnemonic persistent activity. Trends in Neurosciences, 24, 455-463. doi:10.1016/S0166-2236(00)01868-3 [12] Mitzdorf, U. (1987) Properties of the evoked potential generators: Current source-density analysis of visually evoked potentials in the cat cortex. International Journal of Neuroscience, 33, 33-59. doi:10.3109/00207458708985928 [13] Logothetis, N.K. (2003) The underpinnings of the BOLD functional magnetic resonance imaging signal. Journal of Neuroscience, 23, 3963-3971. [14] Fries, P., Reynolds, J.H., Rorie, A.E. and Desimone, R. (2001) Modulation of oscillatory neuronal synchronization by selective visual attention. Science, 291, 1560-1563. doi:10.1126/science.1055465 [15] Pesaran, B., Pezaris, J.S., Sahani, M., Mitra, P.P. and Andersen, R.A. (2002) Temporal structure in neuronal activity during working memory in macaque parietal cortex. Nature Neuroscience, 5, 805-811. doi:10.1038/nn890 [16] Siegel, M. and Konig, P. (2003) A functional gamma-band defined by stimulus-dependent synchronization in area 18 of awake behaving cats. Journal of Neuroscience, 23, 4251-4260. [17] Gail, A., Brinksmeyer, H.J. and Eckhorn, R. (2004) Perception-related modulations of local field potential power and coherence in primary visual cortex of awake monkey during binocular rivalry. Cerebral Cortex, 14, 300-313. doi:10.1093/cercor/bhg129 [18] Henrie, J.A. and Shapley, R. (2005) LFP power spectra in V1 cortex: The graded effect of stimulus contrast. Journal of Neurophysiology, 94, 479-490. doi:10.1152/jn.00919.2004 [19] Rickert, J., Oliveira, S.C., Vaadia, E., Aertsen, A., Rotter, S. and Mehring, C. (2005) Encoding of movement direction in different frequency ranges of motor cortical local field potentials. Journal of Neuroscience, 25, 8815-8824. doi:10.1523/JNEUROSCI.0816-05.2005 [20] Scherberger, H., Jarvis, M.R. and Andersen, R.A. (2005) Cortical local field potential encodes movement intentions in the posterior parietal cortex. Neuron, 46, 347-354. doi:10.1016/j.neuron.2005.03.004 [21] Taylor, K., Mandon, S., Freiwald, W.A. and Kreiter, A.K. (2005) Coherent oscillatory activity in monkey area v4 predicts successful allocation of attention. Cerebral Cortex, 15, 1424-1437. doi:10.1093/cercor/bhi023 [22] Womelsdorf, T., Fries, P., Mitra, P.P. and Desimone, R. (2006) Gamma-band synchronization in visual cortex predicts speed of change detection. Nature, 439, 733-736. doi:10.1038/nature04258 [23] Nicolelis, M.A., Ghazanfar, A.A., Faggin, B.M., Votaw, S. and Oliveira, L.M. (1997) Reconstructing the engram: Simultaneous, multisite, many single neuron recordings. Neuron, 18, 529-537. [24] De Coteau, W.E., Thorn, C., Gibson, D.J., Courtemanche, R., Mitra, P., Kubota, Y. and Graybiel, A.M. (2007) Oscillations of local field potentials in the rat dorsal striatum during spontaneous and instructed behaviors. Journal of Neurophysiology, 97, 3800-3805. doi:10.1152/jn.00108.2007 [25] Courtemanche, R. and Lamarre, Y. (2005) Local field potential oscillations in primate cerebellar cortex: Synchronization with cerebral cortex during active and passive expectancy. Journal of Neurophysiology, 93, 2039-2052. [26] Murthy, V.N. and Fetz, E.E. (1996) Oscillatory activity in sensorimotor cortex of awake monkeys: Synchronization of local field potentials and relation to behavior. Journal of Neurophysiology, 76, 3949-3967. [27] Dressler, I., Fritzsche, T., Cortina, K., Pragst, F., Spies, C. and Rundshagen, I. (2007) Psychomotor dysfunction after remifentanil/propofol anaesthesia. European Journal of Anaesthesiology, 24, 347-354. doi:10.1017/S0265021506001530 [28] Kaoua, N.B., Veron, A.L., Lespinet, V.C., Claverie, B. and Sztark, F. (2002) Time course of cognitive recovery after propofol anaesthesia: A level of processing approach. Journal of Clinical and Experimental Neuropsychology, 24, 713-719. [29] Sanou, J., Goodall, G., Capuron, L., Bourdalle-Badie, C. and Maurette, P. (1996) Cognitive sequelae of propofol anaesthesia. NeuroReport, 7, 1130-1132. doi:10.1097/00001756-199604260-00005 [30] Manahan-Vaughan, D., von Dorothea, H., Winter, C., Juckel, G. and Heinemann, U. (2008) A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats. Hippocampus, 18, 125-134. doi:10.1002/hipo.20367 [31] Simon, W., Hapfelmeier, G., Kochs, E., Zieglgansberger, W. and Rammes, G. (2001) Isoflurane blocks synaptic plasticity in the mouse hippocampus. Anesthesiology, 94, 1058-1065. doi:10.1097/00000542-200106000-00021 [32] Mehring, C., Rickert, J., Vaadia, E., Cardosa, de Oliveira, S., Aertsen, A. and Rotter, S. (2003) Inference of hand movements from local field potentials in monkey motor cortex. Nature Neuroscience, 6, 1253-1254. doi:10.1038/nn1158 [33] Toshiyuki, H. and Yasushi, M. (2005) Dynamically modulated spike correlation in monkey inferior temporal cortex depending on the feature configuration within a whole object. Journal of Neuroscience, 25, 10299-10307. doi:10.1523/JNEUROSCI.3036-05.2005