ABSTRACT Encephalopathy, extrapyramidal features, neurodegenerative diseases, and peripheral neuropathy are commonly encountered in presentations of occupational neurotoxic syndromes. Epidemiological findings have suggested the role of pesticides, solvents and metals on the onset and progression of neurological diseases. The aim of this review is to present clinical manifestations of occupational and environmental neurologic disorders, to discuss toxic’s implications of these conditions, and to give indications about occupational branches and main jobs concerned. Better to know and categorize the clinical manifestation of neurologic disorders and toxics implicated, will improve the clinical management of occupational neurologic diseases. We performed a research of studies, case reports and review, particularly among most recent, available into Pub Med databases about occupational and environmental neurologic disorders and main toxics incriminated.
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Caroline, M. and Frederic, D. (2012) Nervous system disorders induced by occupational and environmental toxic exposure. Open Journal of Preventive Medicine, 2, 272-278. doi: 10.4236/ojpm.2012.23039.
 Prince, T.S. and Spengler, S.E. (2000) Severe headache associated with occupational exposure to Stoddard solvent. Occupational Medicine, 51, 136-138.
 Bour, H. and McA Ledingham, I. (1968) Carbon monoxide poisoning, vol. 24. Progress in Brain Research, 122, 283-283. doi:10.1001/archinte.1968.00300080091023
 Ellingsen, D.G., Kusraeva, Z., Bast-Pettersen, R., Zibarev, E., Chashchin, M., Thomassen, Y. and Chashchin, V. (2011) A follow-up of neurobehavioral functions in welders exposed to manganese. 13th International Neurotoxicology Association Meeting and 11th International Symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health, Xi’an.
 Senanayake, N. and Sanmuganathan, P.S. (1995) Extrapyramidal manifestation complicating organophosphorus insecticide poisoning. Human & Experimental Toxicology, 14, 600-604.
 Sinczuk-Walczak, H. (2009) Nervous system disorders induced by occupational exposure to arsenic and its inorganic compounds: A literature review. Medycyna Pracy, 60, 519-522.
 Kutlu, G., Gomcell, Y.B., Sonmez, T. and Inan, L.E. (2009) Peripheral neuropathy and visual evoked potential changes in workers exposed to n-hexane. Journal of Clinical Neuroscience, 16, 1296-1299.
 Van Valen, E., Wekking, E., van der Laan, G., Sprangers, M. and van Dijk, F. (2009) The course of chronic solvent induced encephalopathy: A systematic review. Neuro-Toxicology, 30, 1172-1186.
 Yücel, M., Takagi, M. Walterfang, M. and Lubman. D.I. (2008) Toluene misuse and long-term harms: A systematic review of the neuropsychological and neuroimaging literature. Neuroscience & Behavioral Rewiews, 32, 910- 926.
 Ascherio, A., Chen, H., Weisskopf, M., O’Reilly, E., McCullough, M., Calle, E., Schwarzschild, M. and Thun, M. (2006) Pesticide exposure and risk for Parkinson’s disease. Annals of Neurology, 60, 197-203.
 Tanner, C.M., Kamel, F., Ross, G.W., Hoppin, J.A. Goldman, S.M., Korell, M., Marras, C., Bhudhikanok, G.S., Kasten, M., Chade, A.R., Comyns, K., Richards, M.B., Meng, C., Priestley, B., Fernandez, H.H., Cambi, F., Umbach, D.M., Blair, A., Sandler, D.P. and Langston, J.W. (2011) Rotenone, paraquat, and Parkinson’s disease. Environmental Health Perspectives, 119, 886-872.
 Mutter, J., Curth, A., Naumann, J., Deth, R. and Walach, H. (2010) Does inorganic Mercury play a role in Alz- heimer’s disease? A systematic review and an integrated molecular mechanism. Journal of Alzheimer’s Disease, 22, 357-374.
 Bouchard, M., Mergler, D., Baldwin, M., Panisset, M. and Roels, H.A. (2007) Neuropsychiatric symptoms and past manganese exposure in a ferro-alloy plant. Neuro-Toxicology, 28, 290-297.
 Calne, D.B., Chu, N.S., Huang, C.C., Lu, C.S. and Olanow, W. (1994) Manganism and idiopathic Parkinsonism: Similarities and differences. Neurology, 44, 1583-1586.
 Guyton, A. and Hall, J. (1996) Textbook of medical physiology. 9th Edition, Saunders, Philadelphia.
 McMillian, D.E. (1999) A brief history of the neurobehavioral toxicity of manganese: Some unanswered questions. NeuroToxicology, 20, 499-507.
 Huang, C.-C. (2007) Med J. March.