OJSTA  Vol.1 No.2 , July 2012
Improved Solid-Phase Peptide Synthesis of Wild-Type and Phosphorylated Phospholamban Using a Pseudoproline Dipeptide
ABSTRACT
In this study, we report that the insertion of a pseudoproline dipeptide for the solid-phase peptide synthesis of wild-type Phospholamban protein (WT-PLB) has two important advantages. First, it disrupts the formation of different secondary structures, which is responsible for poor couplings during the preparation of highly aggregated sequences. Second, it enhances the purities and solubility of crude products leading to easier HPLC purification.

Cite this paper
S. Abu-Baker and G. Lorigan, "Improved Solid-Phase Peptide Synthesis of Wild-Type and Phosphorylated Phospholamban Using a Pseudoproline Dipeptide," Open Journal of Synthesis Theory and Applications, Vol. 1 No. 2, 2012, pp. 9-12. doi: 10.4236/ojsta.2012.12002.
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