ABSTRACT Bacterial pathogens and drug resistance are different in hospitals of each country. In this study we determined bacterial path- ogens and drug sensitivity in the neonatal ward and neonatal intensive care unit (NICU) in Ekbatan hospital in Hamedan. This cross-sectional descriptive study was done on 1150 hospitalized neonates in neonatal and NICU wards of Ekbatan hospital of the Hamadan university of medical sciences from September 2004 to September 2006. Blood, cerebrospinal fluid (CSF), urine, stool, eye excretion, synovial fluid, umbilical secretion and ascitic fluid were evaluated. Positive cultures were evaluated for antibiotic resistance with disk diffusion test methed. All of the data in questionnaires was analyzed with SPSS 13. Cultures including blood, urine, CSF , stool, eye excretion, synovial fluid, umbilical secretion and ascitic fluid was done in 417 neonates (833 cultures). These cultures were including: urine, 323 cases (38.8%) blood 293 cases (35.2%), CSF 180 cases (21.6%) , stool 17 cases (2%), eye secretion 16 cases (1.9%) and other secretions (synovial, umbilical, etc) 4 cases (0.5%). The cultures were positive in 105 cases (25.2%). 60 male neonates (57.1%) and 45 female neonates (42.9%) were culture positive. The most common microorganisms were E coli 66.7% (70 cases), Klebsiella 10.5% (11 cases). Drug resistance was high in these microorganisms. The most common microorganisms were Ecoli and klebsiella. Drug resistance was high in the isolated microorganisms.
Cite this paper
nullMonsef, A. and Eghbalian, F. (2010) Antibiotic sensitivity pattern of common bacterial pathogens in NICU and neonatal ward in Hamedan province of Iran. Health, 2, 625-629. doi: 10.4236/health.2010.26094.
 Behrman, R.E., Kliegman, R.M. and Jenson, H.B. (2007) Nelson textbook of pediatrics. 17th Edition, Saunders, Philadelphia.
 Feigin, R.D., Chery, J.D., Demmier, G.J. and Kapian, S.L. (2004) Textbook of pediatric infectious diseases. 5th Edition, Saunders, Philadelphia.
 Helio, S., Sader, A., Gales, C., et al. (2001) Pathogen frequency and resistance patterns in Brazilian hospitals: Summary of results from three years of the SENTRY antimicrobial surveillance program. The Brazilian Journal of Infectious Diseases, 5(4), 200-214.
 Brooks, G., Jawet, E., Butel, J., Morse, S., et al. (2001) Adelberg’s medical microbiology. 22nd Edition, McGrawHill, New York.
 Zaleznik, D.F. (2005) Hospital-acquired and intravascular device-related infections. In. Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L. and Jameson, J.L., Harrison’s principles of internal medicine, 16th Edition, McGraw-Hill, New York.
 Hawkes, C.A. (2000) Antibiotic resistance: A clinicians perspective. Mil Medicine, 165 (7), 43-45.
 Steven, M.O. (2000) Mechanisms of bacterial antibiotic resistance. In. Mandel, G.L., Principles and practice of infectious disease, 5th Edition, Churchill Livingstone, London.
 Klugman, K.P. and Mahdi, S.A. (1999) Emergence of drug resistance. Infectious Disease Clinics of North America, 13(3), 637-646.
 Pavia, M., Nobile, C. and Salpietro, L. (2000) Vancomycin resistance and antibiotic susceptibility of enterococci in raw meat. Journal of Food Protection, 63(7), 912-915.
 Binsztein, N., Picandet, A. and Notario, R. (1999) Antimicrobial resistance among species of salmonella, shigella, Escherichia, and aeromonas isolated from children with diarrhea in 7 Argentinean centers. Revista Latinoamericana de Microbiología, 41(3), 121-126.
 Yalaz, M., Cetin, H., Akisu, M., Aydemir, S. and Tunger, A. (2006) Neonatal nosocomial sepsis in a level-III NICU: Evaluation of the causative agents and antimicrobial susceptibilities. Turkish Journal of Pediatrics, 48(1), 13-18.
 Aurangzeb, B. and Hameed, A. (2003) Neonatal sepsis in hospital- born babies: bacterial isolates and antibiotic susceptibility patterns. Journal of College of Physicians and Surgeons Pakistan, 13(11), 629-632.
 Collee, J., Duguide, J. and Fraser, A. (1989) Practical medical microbiology. 13th Edition, Churchill Livingstone, New York.
 Bedford, H., Louvois, J., Halket, S., et al. (2001) Meningitis in infancy in England and Wales: follow up at age 5 years. British Medical Journal, 323(7312), 533-536.
 Eghbalian, F. and Yousefi, R. (2005) Determining the frequency of the bacterial agents in urinary tract infection in hospitalized patients under 18 years old. Journal of Army university of medical sciences of the I.R.Iran, 3(3), 636-639.
 Wenger, J., Hightower, A., Facklam, R., et al. (1990) Bacterial meningitis in the United States. Journal of Infectious Diseases, 162(6), 1316-1323.