ABSTRACT This study aimed to characterize energy expenditure patterns using the triaxial accelerometer and to identify the association of energy expenditure with clinical parameters in patients with systemic lupus erythematosus (SLE). Estimates of energy expenditures represented by total activity calorie (TA), physical activity calorie (PA), total activity calorie per body weight (TABW), and physical activity calorie per body weight (PABW) of 49 female SLE patients were assessed using the RT3 triaxial accelerometer (StayHealthy, Monrovia, CA) in a sevenday period. SLE patients in the highest body mass index (BMI) tertile showed significantly lower values of TABW compared to those in the lowest tertile, while SLE patients in the lowest TABW tertile showed significantly higher body weight, waist circumference, BMI, SLE disease activity index (SLEDAI), dosage of prednisone, and blood pressure. There was a high prevalence of metabolic syndrome and SLE patients with metabolic syndrome showed significantly lower TABW. In addition, both TABW and PABW significantly but negatively correlated with SLEDAI. In conclusion, the RT3 accelerometer is suitable for evaluating total and physical activity-related energy expenditure in patients with SLE. TABW measured by the triaxial accelerometer is inversely related with body weight status and disease activity in SLE patients. This suggests that estimates of energy expenditure by the tri-axial accelerometer may be applied in the management of SLE.
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nullTso, T. , Huang, W. and Chang, C. (2010) Estimates of energy expenditure using the RT3 accelerometer in patients with systemic lupus erythematosus. Health, 2, 603-608. doi: 10.4236/health.2010.26089.
 D’Cruz, D.P., Khamashta, M.A. and Hughes, G.R. (2007) Systemic lupus erythematosus. Lancet, 369(9561), 587- 596.
 Vu, T.V. and Escalante, A. (1999) A comparison of the quality of life of patients with systemic lupus erythematosus with and without end-stage renal disease. Journal of Rheumatology, 26(12), 2595-2601.
 Forte, S., Carlone, S., Vaccaro, F., Onorati, P., Manfredi, F., Serra, P. and Palange, P. (1999) Pulmonary gas exchange and exercise capacity in patients with systemic lupus erythematosus. Journal of Rheumatology, 26(12), 2591-2594.
 Tench, C., Bentley, D., Vleck, V., McCurdie, I., White, P. and D’Cruz, D. (2002) Aerobic fitness, fatigue, and physical disability in systemic lupus erythematosus. Journal of Rheumatology, 29(3), 474-481.
 Brown, W.J., Burton N.W. and Rowan P.J. (2007) Up- dating the evidence on physical activity and health in women. American Journal of Preventive Medicine, 33(5), 404-411.
 Lagerros Y.T. and Lagiou P. (2007) Assessment of physical activity and energy expenditure in epidemiol- ogical research of chronic diseases. European Journal of Epidemiology, 22(6), 353-362.
 DeVoe, D., Gotshall, R. and McArthur, T. (2003) Comparison of the RT3 research tracker and tritrac R3D accelerometers. Percept Mot Skills, 97(2), 510-518.
 Powell, S.M. and Rowlands, A.V. (2004) Intermonitor variability of the RT3 accelerometer during typical physical activities. Medicine and Science in Sports and Exercise, 36(2), 324-330.
 Rowlands, A.V., Thomas, P.W., Eston, R.G. and Topping, R. (2004) Validation of the RT3 tri-axial accelerometer for the assessment of physical activity. Medicine and Science in Sports and Exercise, 36(3), 518-524.
 Chu, E.Y., McManus, A.M. and Yu, C.C. (2007) Calibration of the RT3 accelerometer for ambulation and non-ambulation in children. Medicine and Science in Sports and Exercise, 39(11), 2085- 2091.
 De Vries, S.I., Bakker, I., Hopman-Rock, M., Hirasing, R.A. and Van Mechelen, W. (2006) Clinimetric review of motion sensors in children and adolescents. Journal of Clinical Epidemiology, 59(7), 670-680.
 Jacobi, D., Perrin, A.E., Grosman, N., Dore, M.F., Normand, S., Oppert, J.M. and Simon, C. (2007) Physical activity-related energy expenditure with the RT3 and TriTrac accelerometers in overweight adults. Obesity, 15 (4), 950-956.
 DiNallo, J.M., Le, Masurier, G.C., Williams, N.I. and Downs, D.S. (2008) Walking for health in pregnancy: assessment by indirect calorimetry and accelerometry. Research Quarterly for Exercise and Sport, 79(1), 28-35.
 Klassen, L., Schachter, C. and Scudds, R. (2008) An exploratory study of two measures of free-living physical activity for people with multiple sclerosis. Clinical Rehabilitation, 22(3), 260-271.
 Orrell, A., Doherty, P., Miles, J. and Lewin, R. (2007) Development and validation of a very brief questionnaire measure of physical activity in adults with coronary heart disease. European Journal of Cardiovascular Prevention and Rehabilitation, 14(5), 615-623.
 Tan, E.M., Cohen, A.S., Fries, J.F., Masi, A.T., McShane, D.J., Rothfield, N.F., Schaller, J.G., Talal, N. and Winchester, R.J. (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis and Rheumatism, 25(11), 1271-1277.
 Bombardier, C., Gladman, D.D., Urowitz, M.B., Caron, D., Chang, C.H. and the Committee on Prognosis Studies in SLE (1992) Derivation of the SLEDAI: A disease activity index for lupus patients. Arthritis and Rheumatism, 35(6), 630-640.
 Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clinical Chemistry, 18(6), 499-502.
 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Journal of the American Medical Association, 285, 2486-2497.
 Chang, D.M., Lan, J.L., Lin, H.Y. and Luo, S.F. (2002) Dehydroepiandrosterone treatment of women with mild- to-moderate systemic lupus erythematosus. Arthritis and Rheumatism, 46(11), 2924-2927.
 Faulkner, G., Cohn, T. and Remington, G. (2006) Validation of a physical activity assessment tool for individuals with schizophrenia. Schizophrenia Research, 82(3), 225- 231.
 De Carvalho, M.R.P., Sato, E.I., Tebexreni, A.S., Heidecher, R.T.C., Schenkman, S. and Barros Neto, T.L. (2005) Effects of supervised cardio-vascular training program on exercise tolerance, aerobic capacity, and quality of life in patients with systemic lupus erythematosus. Arthritis and Rheumatism, 53(6), 838-844.
 Ramsey-Goldman, R., Schilling, E.M., Dunlop, D., Langman, C., Greenland, P., Thomas, R.J. and Chang, R.W. (2000) A pilot study on the effects of exercise in patients with systemic lupus erythematosus. Arthritis Care and Research, 13(5), 262-269.
 Tench, C.M., McCarthy, J., McCurdie, I., White, P.D. and D’Cruz, D.P. (2003) Fatigue in systemic lupus erythematosus: A randomized controlled trial of exercise. Rheumatology, 42(9), 1050-1054.
 Clarke-Jenssen, A.C., Fredriksen, P.M., Lilleby, V. and Mengshoel, A.M. (2005) Effects of supervised aerobic exercise in patients with systemic lupus erythematosus: A pilot study. Arthritis and Rheumatism, 53(2), 308-312.
 Oeser, A., Chung, C.P., Asanuma, Y., Avalos, I. and Stein, C.M. (2005) Obesity is an independent contributor to functional capacity and inflammation in systemic lupus erythematosus. Arthritis and Rheumatism, 52(11), 3651- 3659.
 Kipen, Y., Briganti, E.M., Strauss, B.J.G., Littlejohn, G.O. and Morand, E.F. (1999) Three-year follow-up of body composition changes in pre-menopausal women with systemic lupus erythematosus. Rheumatology, 38(1), 59- 65.
 Chung, C.P., Avalos, I., Oeser, A., Gebretsadik, T., Shin- tani, A., Raggi, P. and Stein, C.M. (2007) High prevalence of the metabolic syndrome in patients with systemic lupus erythematosus: Association with disease characteristics and cardio-vascular risk factors. Annals of Rheumatic Disease, 66(2), 208-214.
 Sabio, J.M., Zamora-Pasadas, M., Jimenez-Jaimez, J., Albadalejo, F., Vargas-Hitos, J., Rodriguez del Aguila, M.D.M., Hidalgo-Tenorio, C., Gonzalez-Gay, M.A. and Alonso, J.J. (2008) Metabolic syndrome in patients with systemic lupus erythematosus from Southern Spain. Lupus, 17(9), 849-859.
 Ekelund, U., Brage, S., Franks, P.W., Hennings, S., Emms, S. and Wareham, N.J. (2005) Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-aged healthy Caucasians: The Medical Research Council Ely Study. Diabetes Care, 28(5), 1195-1200.