JCPT  Vol.2 No.3 , July 2012
Optimum Kinetic Parameters of Mefenamic Acid Crystallization by PBM
ABSTRACT
Mefenamic acid (MA) is a high-dose, anti-inflammatory, analgesic agent that is widely prescribed for pain related to menstrual disorders. It has some negative properties, such as a high hydrophobicity with a propensity to stick to surfaces, and possess great problems during granulation and tableting. Crystallization kinetics was investigated for mefenamic acid. Availability of data on the kinetics of crystal growth is very important for the development and operation of industrial crystallisation processes. The experiments for the measurement of crystal growth kinetics were carried out using the desupersaturation curve technique based on the measurement of the solution concentration versus time in a seeded isothermal batch experiment. To predict the optimum parameters (b, kb, g, kg) for the nucleation and growth kinetics from the desupersaturation curve obtained, the Population Balance Modelling was used and solved by the method of moments. The initial values for the optimisation problem were estimated by using the approach developed by Garside et al. (1982) [1].

Cite this paper
S. Cesur and C. Yaylaci, "Optimum Kinetic Parameters of Mefenamic Acid Crystallization by PBM," Journal of Crystallization Process and Technology, Vol. 2 No. 3, 2012, pp. 81-95. doi: 10.4236/jcpt.2012.23011.
References
[1]   Garside, J., Evaluation of crystal growth kinetics from a desupersaturation curve using initial derivatives. Chemical Engineering Science, 37, 1625-1628, (1982).

[2]   Cesur, S., S. Gokbel, "Crystallization of mefenamic acid and polymorphs", Crystal Research and Technology, Wiley InterScience, Vol.7/2008, page 720-728, DOI: 10.1002/crat.200711119 (2008).

[3]   Gokbel, S., Crystallisation Kinetics of Mefenamic Acid and Polymorphisim. Master of Science Thesis, Ege University Graduate School of Applied and Natural Sciences, Izmir, Turkey, (2006).

[4]   Gokbel, S. and S. Cesur, "1024-Crystallization kinetics of mefenamic acid and polymorphism",CHISA-2006, 17th International Congress of Chemical and Process Engineering, 27-31 August, Praha, Czech Republic, oral presentation, full paper in CD, (2006).

[5]   Bhadra, S., Kumar, M., Jain, S., Agrawal, S., and Agrawal, G.P., Spherical crystallisation of mefenamic acid. Pharmaceutical Technology, 66-76, (2004).

[6]   Panchagnula, R., Sundaramurthy, P., Pillai, O., Agrawal, S. Raj, Y. A., Solid state characterization of mefenamic acid. Journal of Pharmaceutical Sciences, 93(4), 1019-1029, (2004).

[7]   Adam, A., Schrimpl, L., Schmidt, P.C., Some physicochemical properties of mefenamic acid. Drug Development and Industrial Pharmacy, 26(5), 477-487, (2000).

[8]   Romero, S., Escalera, B., and Bustamante, P., Solubility behavior of polymorphs I and II of mefenamic acid in solvent mixtures. International Journal of Pharmaceutics, 178, 193-202, (1999).

[9]   Cesur S., Gokbel S., Yaylaci C., (Reference #221) "Optimum Crystallization Kinetic Parameters of Mefenamic Acid", 18th International Symposium on Industrial Crystallization, ISIC18, , Zurich, Switzerland, Poster Presentation, 12-17 September (2011).

[10]   Monnier, O., Fevotte, G., Hoff, C., Klein, J. P., Model identification of batch cooling crystallisations through calorimetry and image analysis. Chemical Engineering Science, 52, 1125–1139, (1997).

[11]   Qiu, Y., Rasmuson, A. C., Estimation of crystallisation kinetics from batch cooling experiments. AIChE J., 40, 799–812, (1994).

[12]   Jones, A. G., Budz, J., Mullin, J. W., Batch crystallisation and solid–liquid separation of potassium sulphate. Chemical Engineering Science, 42619–629, (1987).

[13]   Miller, S. M., Rawlings, J. W., Model identification and control strategies for batch cooling crystallizers. AIChE J., 40, 1312–1327, (1994).

[14]   Qui, Y., Rasmuson, A.C., Nucleation and growth of succinic acid in a batch cooling crystallizer. AIChE J., 37(9), 1293-1304, (1991(a)).

[15]   Qui, Y., Rasmuson, A.C., Crystal growth rate parameters from isothermal desupersaturation experiments. Chemical Engineering Science, 46(7), 1659-1667, (1991(b)).

[16]   Bohlin, M., Rasmuson, A.C., Modeling of growth rate dispersion in batch cooling crystallisation. AIChE J., 38(12), 1853-1863, (1992).

[17]   Doki, N., Kubota, N., Sato, A., Yokota, M., Hamada, O., Masumi, F., Scale up experiments on seeded batch cooling crystallisation of potassium alum. AIChE J., 45, 2527–2533, (1999).

[18]   Mohameed, H. A., Abu-Jdayil, B., Al Khateeb, M., Effect of cooling rate on unseeded batch crystallisation of KCl. Chemical Engineering and Processing, 41, 297-302, (2002).

[19]   Rohani, S., Tadayon, A., Bennett, M. K., Estimation of nucleation and growth kinetics of ammonium sulfate from transients of a cooling batch seeded crystallizer. Industrial and Engineering Chemistry Research, 41(24), 6181-6193, (2002).

[20]   Mohameed, H.A., Abdel-Jabbar, N., Takrouri, K., and Nasr, A., Model-based optimal cooling strategy for batch crystallisation processes. Chemical Engineering Research and Design, 81(5), 578-584, (2003).

[21]   Hu, Q., Rohani, S., Wang, D. X., Jutan, A., Nonlinear kinetic parameter estimation for batch cooling seeded crystallisation. AIChE J., 50(8), 1786-1794, (2004).

[22]   Rohani, S., Hu, Q., Wang, D.X., Jutan, A., Nonlinear kinetic parameter estimation for batch cooling seeded crystallisation. AIChE J., 50(8), 1786-1794, (2004).

[23]   Liu, Y., Wan, J. K., Wei, H. Y., Determination of crystallisation kinetics in solution. Journal of Crystal Growth, 271(1-2), 238-244, (2004).

[24]   Hu, Q., Rohani, S., Jutan, A., Modelling and optimisation of seeded batch crystallizers. Computers and Chemical Engineering, 29(4), 911-918, (2005).

[25]   Mohameed, H.A., Abu Jdayil, B., Takrouri, K., Separation of paraxylene from xylene mixture via crystallisation Chemical Engineering and Processing, 46(1), 25-36, (2007).

[26]   Mullin, J. W Crystallization, 4rd Ed., Butterworth Heinemann, Oxford, p. 181-284., (2001).

[27]   Nyvlt, J., Sohnel, O., Matuchova, M., Broul, M., The kinetics of industrial crystallisation, Elsevier, Amsterdam, (1985).

[28]   Tavare, N.S., Batch crystallizers: review. Chemical Engineering Comm., 61, 259-318, (1987).

[29]   Nyvlt, J., Kinetics of crystallisation in solution. Journal of Crystal Growth, 3-4, 377-383, (1968).

[30]   Park, K., Evans, J.M.B., and Myerson, A.S., Determination of solubility of polymorphs using differential scanning calorimetry. Crystal Growth and Design, 1(5), EST 4-7, (2003).

[31]   Myerson, A. S., Ginde, R., Crystals, Crystal Growth and Nucleation, in: Myerson, A. S. (Ed.), Handbook of Industrial Crystallisation, 2nd Ed., Butterworth Heinemann, London, p. 33-63, (2002).

 
 
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