JMMCE  Vol.10 No.8 , June 2011
Synthesis and Characterization of Hydroxyapatite Powder by Sol-Gel Method for Biomedical Application
ABSTRACT
Hydroxyapatite (HA) is effectively used as a bioimplant material because it closely resembles bone apatite and exhibits good biocompatibility. This paper describe synthesis technique of HA powder by sol-gel method. The product was sintered twice at two different temperatures 400°C to 750°C to improve its crystallinity. The final powder sintered at two temperatures was characterized by X-ray analysis, Scanning electron microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR) to reveal its phase content, morphology and types of bond present within it. Thermal analysis (TG–DTA) was carried out to investigate the thermal stability of the powder.

Cite this paper
K. Agrawal, G. Singh, D. Puri and S. Prakash, "Synthesis and Characterization of Hydroxyapatite Powder by Sol-Gel Method for Biomedical Application," Journal of Minerals and Materials Characterization and Engineering, Vol. 10 No. 8, 2011, pp. 727-734. doi: 10.4236/jmmce.2011.108057.
References
[1]   W. Weng, G. Shen, G. Han, 2000, “Low temperature preparation of hydroxyapatite coatings on titanium alloy by a sol-gel route”, Materials Science Letters, Vol. 19, pp. 2187- 2188.

[2]   K. Cheng, W. Weng, G. Han, P. Du, G. Shen, J. Yang, J.M.F. Ferreira, 2003, “The effect of triethanolamine on the formation of sol–gel derived fluoroapatite/hydroxyapatite solid solution”, Journal of Materials Chemistry and Physics, Vol. 78, pp. 767-771.

[3]   R.E. Riman, W.L. Suchanek, K. Byraopa, C-W. Chen, P. Shuk, C.S. Oakes, 2002, “Solution synthesis of hydroxyapatite designer particulates”, Solid State Ionics, Vol. 151, pp. 393- 402.

[4]   L-Y. Huang, K-W. Xu, J. Lu, 2000, “A study of the process and kinetics of electrochemical deposition and the hydrothermal synthesis of hydroxyapatite coatings”, Journal of Materials Science: Materials in Medicine, Vol. 11, pp. 667-673.

[5]   W. Weng, S. Zhang, K. Cheng, H. Qu, P. Du, G. Shen, J. Yuan, G. Han, 2003, “Sol– gel preparation of bioactive apatite films”, Surface and Coatings Technology, Vol. 167, pp. 292-296.

[6]   W. Weng, G. Han, P. Du, G. Shen, 2002, “The effect of citric acid addition on the formation of sol–gel derived hydroxyapatite”, Materials Chemistry and Physics, Vol. 74, pp. 92-97.

[7]   D. Choi, K. Marra, P.N. Kumta, 2004, “Chemical synthesis of hydroxyapatite/poly ( caprolactone) composite”, Materials Research Bulletin, Vol. 39, pp. 417-432.

[8]   W. Weng, J.L. Baptista, 1998, “Alkoxide route for preparing hydroxyapatite and its coatings”, Biomaterials, Vol. 19, pp. 125-131.

[9]   K. Cheng, W. Weng, G. Han, P. Du, G. Shen, J. Yang, J.M.F. Ferreira, 2003, “Sol–gel derived fluoridated hydroxyapatite films”, Materials Research Bulletin, Vol. 38, pp. 89-97.

[10]   K. Cheng, G. Shen, W. Weng, G. Han, J.M.F. Ferreira, J. Yang, 2001, “Synthesis of hydroxyapatite /fluoroapatite solid solution by a sol-gel method”, Materials Letters, Vol. 51, pp. 37- 41.

[11]   W. Weng, G. Han, P. Du, G. Shen, J. Yang, 2002, “The effect of citric acid addition on sol–gel preparation of apatite films”, Materials Chemistry and Physics, Vol. 77, pp. 578-582.

[12]   V. Shiny, P. Ramesh, M.C. Sunny, H.K. Varma, 2000, “Extrusion of hydroxyapatite to clinically significant shapes”, Materials Letters, Vol. 46, pp. 142-146.

[13]   T. Kokubo, H.M. Kim, M. Kawashita, 2003, “Novel bioactive materials with different mechanical properties”, Biomaterials, Vol. 24, pp. 2161-2175.

[14]   L.J. Jha, S.M. Best, J.C. Knoles, I. Rehman, J.D. Santos, W. Bonfield, 1997, “Preparation and characterization of fluoride-substituted apatites”, Journal of Materials Science: Materials in Medicine, Vol. 8, pp. 185-191.

[15]   Y.C. Tsui, C. Doyle, T.W. Clyne, 1998, “Plasma sprayed hydroxyapatite coatings on titanium substrates Part 1: Mechanical properties and residual stress levels”, Biomaterials, Vol. 19, pp. 2015-2029.

[16]   W. Weng, J.L. Baptista, 1997, “A new synthesis of hydroxyapatite”, Journal of the European Ceramic Society, Vol. 17, pp. 1151-1156.

[17]   Dean-Mo Liu, T. Troczynski, Wenjea J. Tseng, 2001, “Water-based sol-gel synthesis of hydroxyapatite: process development”, Biomaterials, Vol. 22, pp. 1721-1730.

[18]   W. Suchanek, M. Yoshimura, 1998, “Processing and properties of hydroxyapatitebased biomaterials for use as hard tissue replacement implants”, Journal of Materials Research, Vol. 13, pp. 94-117.

[19]   J.C. Elliott, 1994, “Structure and Chemistry of the Apatites and Other Calcium Orthophosphates”, Elsevier Science, The Netherlands

[20]   M. Toriyama, A. Ravaglioli, A. Krajewski, G. Gelotti, A. Piancastelli, 1997, “Synthesis of hydroxyapatite-based powders by mechano-chemical method and their sintering”, Journal of the European Ceramic Society, Vol. 16, pp. 429-436.

[21]   M. Otsuka, Y. Matsuda, J. Hsu, J. Fox, W. Higuchi, 1994, “Mechanochemical synthesis of bioactive material: Effect of environmental conditions on the phase transformation of calcium phosphates during grinding”, Bio-Medical Materials and Engineering, Vol. 4, pp. 357-362.

[22]   U. Partenfelder, A. Engel, C. Russel, 1993, “A pyrolytic route for the formation of hydroxyapatite/fluoroapatite solid solutions”, Journal of Materials Science: Materials in Medicine, Vol. 4, pp. 292-295.

[23]   C.J. Brinker, G.W. Scherer, 1990, “Sol–Gel Science”, Academic Press, Boston, pp. 787.

[24]   Haddow DB, James PF, Van Noort R, 1998, “Sol-gel derived calcium phosphate coatings for biomedical applications”, Journal of Sol-Gel Science and Technology, Vol. 13, pp. 261-265.

[25]   Chai CS, Ben-Nissan B, Pyke S, Evans L, 1995, “Sol-gel derived hydroxyapatite coatings for biomedical applications”, Materials and Manufacturing Processes, Vol. 10, pp. 205-216.

[26]   Il-Seok kim, Prashant N.Kumata, “Sol-gel synthesis and characterization of nanostructured hydroxyapatite powder”, Materials science and engineering B, Vol. 111, pp. 232-236, 2004.

[27]   W. Weng, J.L. Baptista, 1998, “Sol-gel derived porous hydroxyapatite coatings”, Journal of materials science: materials in medicine”, Vol. 9, pp. 159-163.

[28]   LeGeros, R.Z.,“Calcium Phosphate in Oral Biology and Medicine”, Karger: Basel, 1991.

[29]   Tas, A.C, 2000, “Synthesis of biomimetic Ca hydroxyapatite powders at 37℃ in synthetic body fluids”, Biomaterials, Vol. 21, pp. 1429.

 
 
Top