ABSTRACT Calcium hydrogen phosphate dihydrate (CHPD, CaHPO4· 2H2O) or brushite is found quite frequently in urinary calculi (stones). Crystallization of brushite has been carried out in sodium metasilicate (SMS) gel with and without adding ‘Sr’ as additive. In pure system, dicalcium phosphate anhydrous (DCPA, CaHPO4) or monetite and hydroxyapatite (HA, Ca5(PO4)3(OH)) grew along with brushite. The presence of Sr suppressed the formation of HA and enhanced the number and size of monetite crystals and changed the morphology of brushite crystals from needle shape to octopus-like shape. The samples were characterized by powder & single crystal X-ray diffraction (XRD), scanning electron microscopy (SEM), Xray fluorescence spectroscopy (XRF), Fourier transform infrared spectroscopy (FTIR) and thermal analyses (TG-DTA).
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K. Suguna and C. Sekar, "Role of Strontium on the Crystallization of Calcium Hydrogen Phosphate Dihydrate (CHPD)," Journal of Minerals and Materials Characterization and Engineering, Vol. 10 No. 7, 2011, pp. 625-636. doi: 10.4236/jmmce.2011.107048.
 Ryu, H.S., Youn, H.J., Sun Hong, K., Chang, B.S., Lee, C.K., Chung, S.S., 2002, “An improvement in sintering property of ?-tricalcium phosphate by addition of calcium phosphate.” Biomaterials, vol.23, pp. 909-914.
Tadayyon, A., Arifuzzaman, S.M., Rohani, S., 2003, “Reactive Crystallization of Brushite under Steady State and Transient Conditions: Modeling and Experiment.” Ind. Eng. Chem. Res., vol. 42, pp. 6774-6785.
Pak, C.Y.C., Eanes, E.D., Ruskin, B., 1971, “Spontaneous Precipitation of Brushite in Urine: Evidence that Brushite is the Nidus of Renal Stones Originating as Calcium Phosphate.” Proceedings of the National Academy of Sciences of the United States of America, vol. 68, pp. 1456-1460.
Moroz, T.N., Palchik, N.A., Dar, A.V., 2009, “Microelemental and mineral compositions of pathogenic biomineral concrements: SRXFA, X-ray powder diffraction and vibrational spectroscopy data.” Nuclear Instruments and Methods in Physics Research Section A:Accelerators, Spectrometers, Detectors &Associated Equipment, vol. 603, pp. 141-143.
Suresh, P., Kanchana, G., Sundaramoorthi, P., 2009, “Growth and Characterization Studies of MnHP Single Crystal in Silica Gel Medium.” J. Minerals Materials Characterization Engineering, vol. 8, pp. 349-357.
Lundager Madsen, H.E., 2008, “Influence of foreign metal ions on crystal growth and morphology of brushite (CaHPO4, 2H2O) and its transformation to octacalcium phosphate and apatite.” J. Cryst. Growth, vol. 310, pp. 2602-2612.
Sekar, C., Kanchana, P., Nithyaselvi, R., Girija, E.K., 2009, “Effect of fluorides (KF and NaF) on the growth of dicalcium phosphate dihydrate (DCPD) crystal.” Mater. Chem. Phys. vol. 115, pp. 21-27.
Sivakumar, G.R., Narayana Kalkura, S., Ramasamy, P., 1999, “Effect of magnesium on the crystallization and hardness of dicalcium phospahate dihydrate.” Mater. Chem. Phys. vol. 57, pp. 238-243.
Legeros, R.Z., 1972, “Brushite crystals grown by diffusion in silica gel and in solution.”
J. Cryst. Growth, vol. 13-14, pp. 476-480.
Pors Nielsen, S., 2004, “The biological role of strontium.” Bone, vol. 35, pp. 583-588.
Verberckmoes, S. C., De Broe, M.E., D' Haese, P.C., 2003, “Dose-dependent effects of
strontium on osteoblast function & mineralization.” Kidney Int. vol. 64, pp. 534–543.
Bazin, D., Carpentier, X., Brocheriou, I., Dorfmuller, P., Aubert, S., Chappard, C.,Thiaudiere, D., Reguer,S., Waychunas,G., Jungers, P., Daudon, M., 2009, “Revisiting the localization of Zn2+ cations sorbed on pathological apatite calcifications made through X-ray absorption spectroscopy .” Biochimie. vol.91, pp. 1294 -1300.
Kalkura, S.N., Vaidyan, V.K., Kanakavel M., Ramasamy, P., 1993, “Crystallization of uric acid.” J. Cyst. Growth, vol. 132, pp. 617-620.
Joshi, V.S., Joshi, M.J., 2003, “FTIR spectroscopic, thermal and growth morphological studies of calcium hydrogen phosphate dihydrate crystals.” Cryst. Res. Technol., vol. 38, pp. 817-821.
Imai, H., Terada, T., Miura T., Yamabi, S., 2002, “Self-organized formation of porous aragonite with silicate.” J. Cryst. Growth, vol. 244, pp. 200-205.
Bigi, A., Gazzano, M., Ripamonti, A., Roveri, N., 1988, “Effect of foreign ions on the conversion of brushite and octacalcium phosphate into hydroxyapatite.” J. Inorg. Biochem., vol. 32, pp. 251-257.
Hamdan Alkhraisat, M., Tamimi Marino, F., Rueda Rodriguez, C., Blanco Jerez, L., Lopez Cabarcos, E., 2008, “Combined effect of strontium and pyrophosphate on the properties of brushite cements.” Acta Biomaterialia, vol. 4, pp. 664-670.
Boanini, E., Gazzano, M., Bigi, A., 2010, “Ionic substitutions in calcium phosphates synthesized at low temperature.” Acta Biomaterialia, vol. 6, pp. 1882- 1894.
Sauer, G.R., Zunic, W.B., Durig, J.R., Wuthier, R.E., 1994, “Fourier transform raman spectroscopy of synthetic and biological calcium phosphates.” Calcif. Tissue. Int. vol.54, pp. 414-420.
Xu, J., Butler, I.S., Gilson, D.F.R., 1999, “FT-Raman and high-pressure infrared spectroscopic studies of dicalcium phosphate dihydrate (CaHPO4?2H2O) and anhydrous dicalcium phosphate (CaHPO4).” Spectrochim. Acta Part A, vol. 55, pp. 2801-2809.
Petrov, I., Soptrajanov, B., Fuson, N., Lawson, J.R., 1967, “Infra-red investigation of dicalcium phosphates.” Spectrochim. Acta. A, vol. 23, pp. 2637-2646.
Beevers, C.A., 1958, “The crystal structure of dicalcium phosphate dihydrate, CaHPO4.2H2O.” Acta Cryst., vol.11, pp. 273-277.
Berry, E.E., Baddiel, C.B., 1967, “ The infra-red spectrum of dicalcium phosphate dihydrate(brushite).” Spectrochim. Acta. A, vol. 23, pp. 2089-2097.