Opsoclonus-Myoclonus Syndrome Post-Vaccination and Viral Illness

Amanda  L. Piquet; Milind  Kothari; David  Ermak; Aiesha  Ahmed

doi:10.4236/ijcm.2012.34060

Amanda L. Piquet^*, Milind Kothari, David Ermak, Aiesha Ahmed

Abstract: Opsoclonus-myoclonus syndrome is a rare condition with dyskinesia of eye movements and myoclonic movements of the trunk and limbs. It is linked to malignancies, infections and other conditions. We present a case of post-vaccination opsoclonus-myoclonus syndrome. We believe that our patient also experienced a viral illness post-vaccination and prior to the development of opsoclonus-myoclonus. The vaccination in combination with the viral illness potentiated the immune mechanism thought to be noted in this condition. This was supported by her recovery after receiving immunotherapy.

Keywords: Opsoclonus; Myoclonus; Ataxia; Immunotherapy

Cite this paper: A. L. Piquet, M. Kothari, D. Ermak and A. Ahmed, "Opsoclonus-Myoclonus Syndrome Post-Vaccination and Viral Illness," International Journal of Clinical Medicine, Vol. 3 No. 4, 2012, pp. 304-306. doi: 10.4236/ijcm.2012.34060.

References

[1] A. Wong, “An Update on Opsoclonus,” Current Opinion in Neurology, Vol. 20, No. 1, 2007, pp. 25-31. doi:10.1097/WCO.0b013e3280126b51

[2] S. J. Groiss, M. Siebler and A. Schnitzler, “Full Recovery of Adult Onset Opsoclonus Myoclonus Syndrome after Early Immunotherapy: A Case Report,” Movement Disorders, Vol. 26, No. 10, 2011, pp. 1805-1807. doi:10.1002/mds.23854

[3] A. Kirsten, S. Beck, V. Fuhlhuber, M. Kaps, T. Kreutz, M. Korfei, S. Schmitt, K. T. Preissner and F. Blaes, “New Autoantibodies in Pediatric Opsoclonus Myoclonus Syndrome,” Annals of the New York Academy of Sciences, Vol. 1110, 2007, pp. 256-260. doi:10.1196/annals.1423.027

[4] L. Raffaghello, M. Conte, E. De Grandis and V. Pistoia, “Immunological Mechanisms in Opsoclonus-Myoclonus Associated Neuroblastoma,” European Journal of Paediatric Neurology, Vol. 13, No. 3, 2009, pp. 219-223. doi:10.1016/j.ejpn.2008.04.012

[5] N. Kanjanasut, K. Phanthumchinda and R. Bhidayasiri, “HIV-Related Opsoclonus-Myoclonus-Ataxia Syndrome: Report on Two Cases,” Clinical Neurology and Neurosurgery, Vol. 112, No. 7, 2010, pp. 572-574. doi:10.1016/j.clineuro.2010.03.024

[6] K. B. Digre, “Opsoclonus in Adults. Report of Three Cases and Review of the Literature,” Archives of Neurology, Vol. 43, No. 11, 1986, pp. 1165-1175. doi:10.1001/archneur.1986.00520110055016

[7] A. Alshekhlee, B. Sultan and K. Chandar, “Opsoclonus Persisting during Sleep in West Nile Encephalitis,” Archives of Neurology, Vol. 63, No. 9, 2006, pp. 1324-1326. doi:10.1001/archneur.63.9.1324

[8] L. Peter, J. Jung, C. Tilikete, P. Ryvlin and F. Mauguiere, “Opsoclonus-Myoclonus as a Manifestation of Lyme Disease,” Journal of Neurology, Neurosurgery & Psychiatry, Vol. 77, No. 9, 2006, pp. 1090-1091. doi:10.1136/jnnp.2006.091728

[9] V. Medrano, C. Royo-Villanova, J. J. Flores-Ruiz, A. P. Sempere and S. Mola-Caballero de Roda, “Parainfectious Opsoclonus-Myoclonus Syndrome Secondary to Varicella-Zoster Virus Infection,” Revista de Neurologia, Vol. 41, No. 8, 2005, pp. 507-508.

[10] L. Bataller, F. Graus, A. Saiz and J. J. Vilchez, “Clinical Outcome in Adult Onset Idiopathic or Paraneoplastic Opsoclonus-Myoclonus,” Brain, Vol. 124, No. 2, 2001, pp. 437-443. doi:10.1093/brain/124.2.437

[11] J. E. McCarthy and J. Filiano, “Opsoclonus Myoclonus after Human Papilloma Virus Vaccine in a Pediatric Patient,” Parkinsonism & Related Disorders, Vol. 15, No. 10, 2009, pp. 792-794. doi:10.1016/j.parkreldis.2009.04.002

[12] F. Lapenna, L. Lochi, M. de Mari, G. Iliceto and P. Lamberti, “Post-Vaccinic Opsoclonus-Myoclonus Syndrome: A Case Report,” Parkinsonism & Related Disorders, Vol. 6, No. 4, 2000, pp. 241-242. doi:10.1016/S1353-8020(00)00020-1

[13] K. Bhatia, P. D. Thompson and C. D. Marsden, “‘Isolated’ Postinfectious Myoclonus,” Journal of Neurology, Neurosurgery & Psychiatry, Vol. 55, No. 11, 1992, pp. 1089-1091. doi:10.1136/jnnp.55.11.1089