Opsoclonus-Myoclonus Syndrome Post-Vaccination and Viral Illness
Affiliation(s)
Department of Neurology, The Pennsylvania State University Hershey Medical Center, Hershey, PA, US..
Department of Neurology, The Pennsylvania State University Hershey Medical Center, Hershey, PA, US..
ABSTRACT
Opsoclonus-myoclonus syndrome is a rare condition with dyskinesia of eye movements and myoclonic movements of the trunk and limbs. It is linked to malignancies, infections and other conditions. We present a case of post-vaccination opsoclonus-myoclonus syndrome. We believe that our patient also experienced a viral illness post-vaccination and prior to the development of opsoclonus-myoclonus. The vaccination in combination with the viral illness potentiated the immune mechanism thought to be noted in this condition. This was supported by her recovery after receiving immunotherapy.
Opsoclonus-myoclonus syndrome is a rare condition with dyskinesia of eye movements and myoclonic movements of the trunk and limbs. It is linked to malignancies, infections and other conditions. We present a case of post-vaccination opsoclonus-myoclonus syndrome. We believe that our patient also experienced a viral illness post-vaccination and prior to the development of opsoclonus-myoclonus. The vaccination in combination with the viral illness potentiated the immune mechanism thought to be noted in this condition. This was supported by her recovery after receiving immunotherapy.
Cite this paper
A. L. Piquet, M. Kothari, D. Ermak and A. Ahmed, "Opsoclonus-Myoclonus Syndrome Post-Vaccination and Viral Illness," International Journal of Clinical Medicine, Vol. 3 No. 4, 2012, pp. 304-306. doi: 10.4236/ijcm.2012.34060.
A. L. Piquet, M. Kothari, D. Ermak and A. Ahmed, "Opsoclonus-Myoclonus Syndrome Post-Vaccination and Viral Illness," International Journal of Clinical Medicine, Vol. 3 No. 4, 2012, pp. 304-306. doi: 10.4236/ijcm.2012.34060.
References
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[1] A. Wong, “An Update on Opsoclonus,” Current Opinion in Neurology, Vol. 20, No. 1, 2007, pp. 25-31. doi:10.1097/WCO.0b013e3280126b51 [2] S. J. Groiss, M. Siebler and A. Schnitzler, “Full Recovery of Adult Onset Opsoclonus Myoclonus Syndrome after Early Immunotherapy: A Case Report,” Movement Disorders, Vol. 26, No. 10, 2011, pp. 1805-1807. doi:10.1002/mds.23854 [3] A. Kirsten, S. Beck, V. Fuhlhuber, M. Kaps, T. Kreutz, M. Korfei, S. Schmitt, K. T. Preissner and F. Blaes, “New Autoantibodies in Pediatric Opsoclonus Myoclonus Syndrome,” Annals of the New York Academy of Sciences, Vol. 1110, 2007, pp. 256-260. doi:10.1196/annals.1423.027 [4] L. Raffaghello, M. Conte, E. De Grandis and V. Pistoia, “Immunological Mechanisms in Opsoclonus-Myoclonus Associated Neuroblastoma,” European Journal of Paediatric Neurology, Vol. 13, No. 3, 2009, pp. 219-223. doi:10.1016/j.ejpn.2008.04.012 [5] N. Kanjanasut, K. Phanthumchinda and R. Bhidayasiri, “HIV-Related Opsoclonus-Myoclonus-Ataxia Syndrome: Report on Two Cases,” Clinical Neurology and Neurosurgery, Vol. 112, No. 7, 2010, pp. 572-574. doi:10.1016/j.clineuro.2010.03.024 [6] K. B. Digre, “Opsoclonus in Adults. Report of Three Cases and Review of the Literature,” Archives of Neurology, Vol. 43, No. 11, 1986, pp. 1165-1175. doi:10.1001/archneur.1986.00520110055016 [7] A. Alshekhlee, B. Sultan and K. Chandar, “Opsoclonus Persisting during Sleep in West Nile Encephalitis,” Archives of Neurology, Vol. 63, No. 9, 2006, pp. 1324-1326. doi:10.1001/archneur.63.9.1324 [8] L. Peter, J. Jung, C. Tilikete, P. Ryvlin and F. Mauguiere, “Opsoclonus-Myoclonus as a Manifestation of Lyme Disease,” Journal of Neurology, Neurosurgery & Psychiatry, Vol. 77, No. 9, 2006, pp. 1090-1091. doi:10.1136/jnnp.2006.091728 [9] V. Medrano, C. Royo-Villanova, J. J. Flores-Ruiz, A. P. Sempere and S. Mola-Caballero de Roda, “Parainfectious Opsoclonus-Myoclonus Syndrome Secondary to Varicella-Zoster Virus Infection,” Revista de Neurologia, Vol. 41, No. 8, 2005, pp. 507-508. [10] L. Bataller, F. Graus, A. Saiz and J. J. Vilchez, “Clinical Outcome in Adult Onset Idiopathic or Paraneoplastic Opsoclonus-Myoclonus,” Brain, Vol. 124, No. 2, 2001, pp. 437-443. doi:10.1093/brain/124.2.437 [11] J. E. McCarthy and J. Filiano, “Opsoclonus Myoclonus after Human Papilloma Virus Vaccine in a Pediatric Patient,” Parkinsonism & Related Disorders, Vol. 15, No. 10, 2009, pp. 792-794. doi:10.1016/j.parkreldis.2009.04.002 [12] F. Lapenna, L. Lochi, M. de Mari, G. Iliceto and P. Lamberti, “Post-Vaccinic Opsoclonus-Myoclonus Syndrome: A Case Report,” Parkinsonism & Related Disorders, Vol. 6, No. 4, 2000, pp. 241-242. doi:10.1016/S1353-8020(00)00020-1 [13] K. Bhatia, P. D. Thompson and C. D. Marsden, “‘Isolated’ Postinfectious Myoclonus,” Journal of Neurology, Neurosurgery & Psychiatry, Vol. 55, No. 11, 1992, pp. 1089-1091. doi:10.1136/jnnp.55.11.1089