IJOC  Vol.2 No.2 , June 2012
Synthesis and Antitumor Activity of the Thiazoline and Thiazine Multithioether
ABSTRACT
A series of novel multithioether derivatives were synthesized by the combination of thiazoline and thiazine with dibro- mides and their structures were characterized by IR, 1H NMR, MS and elemental analysis. The synthesized derivatives were tested for antitumor activity.

Cite this paper
W. Wang, B. Zhao, C. Xu and W. Wu, "Synthesis and Antitumor Activity of the Thiazoline and Thiazine Multithioether," International Journal of Organic Chemistry, Vol. 2 No. 2, 2012, pp. 117-120. doi: 10.4236/ijoc.2012.22018.
References
[1]   A. Adams and N. De Kimpe, “Chemistry of 2-acetyl-1- pyr-roline, 6-Acetyl-1,2,3,4-tetrahydropyridine, 2-Acetyl-2- thiazoline, and 5-Acetyl-2,3-dihydro-4H-thiazine:?Extraordinary Maillard Flavor Compounds,” Chemical Reviews, Vol. 106, No. 6, 2006, pp. 2299-2319. doi:10.1021/cr040097y

[2]   D. M. Du, S. F. Lu, T. Fang and J. X. Xu, “Asymmetric Henry Reaction Catalyzed by C2-Symmetric Tridentate Bis(oxazoline) and Bis(thiazoline) Complexes:?Metal-Controlled Reversal of Enantioselectivity,” Journal of Organic Chemistry, Vol. 70, No. 9, 2005, pp. 3712-3715. doi:10.1021/jo050097d

[3]   Z. Jin, “Muscarine, Imidazole, Oxazole, and Thiazole Alkaloids,” Natural Product Reports, Vol. 20, No. 6, 2003, pp. 584-605. doi:10.1039/b304142p

[4]   J. R. Lewis, “Amaryllidaceae, Sceletium, Imidazole, Oxazole, Thiazole, Peptide and Mis-cellaneous Alkaloids,” Natural Product Reports, Vol. 19, No. 2, 2002, pp. 223- 258. doi:10.1039/b007741k

[5]   S. F. Lu, D. M. Du, J. X. Xu and S. W. Zhang, “Asymmetric Michael Addition of Nitroalkanes to Nitroalkenes Catalyzed by C2-Symmetric Tridentate Bis(oxazoline) and Bis(thiazoline) Zinc Complexes,” Journal of the American Chemical Society, Vol. 128, No. 23, 2006, pp. 7418- 7419. doi:10.1021/ja0604008

[6]   M. Melchior, K. H. Thompson, J. M. Jong, et al., “Vana- dium Complexes as Insulin Mimetic Agents: Coordination Chemistry and in Vivo Studies of Oxovanadium(IV) and Dioxovanadate(V) Complexes Formed from Naturally Occurring Chelating Oxazolinate, Thiazolinate, or Picolinate Units,” Inorganic Chemistry, Vol. 38, No. 10, 1999, pp. 2288-2293. doi:10.1021/ic981231y

[7]   S. T. A. Shah, K. M. Khan, A. M. Heinrich, et al., “An Alternative Approach towards the Syntheses of Thioethers and Thioesters Using CsF-Celite in Acetonitrile,” Tetra- hedron Letters, Vol. 43, No. 46, 2002, pp. 8281-8283. doi:10.1016/S0040-4039(02)02028-2

[8]   E. Shuter, H. R. Hoveyda, V Karunaratne, et al., “Bis (ligand) Rhenium(V) and Technetium(V) Complexes of Two Naturally Occurring Binding Moieties (Oxazoline and Thiazoline),” Inorganic Chemistry, Vol. 35, No. 2, 1996, pp. 368-372. doi:10.1021/ic9507528

[9]   B. Zhao, Y. Q. Feng and S. S. Zhang, “Novel Synthesis and Characterization of 1,3-Bis(2-dihydrothiazolyl) thia-alkoxy-p-tert-butylcalix[4]arenes,” Synthetic Communications, Vol. 37, No. 20, 2007, pp. 3479-3484. doi:10.1080/00397910701555212

[10]   M. Jain, P. Khanna and A. Saxena, “Synthesis of Some Novel Bis-spiro[indole-pyrazolinyl-thiazolidine]-2,4’- diones,” Synthetic Communications, Vol. 36, 2006, pp. 1863-1872. doi:10.1080/00397910600602560

[11]   A. Dandia, M. Saha and B. Rani, “Microwave-Induced Synthesis of Spiro[indoline-3,2’-[1,3]thiazinane]-2,4’- diones,” Journal of Chemical Research, Synopses, Vol. 7, 1998, pp. 360-361. doi:10.1039/a706678c

[12]   X. Zhai, J. Li, L. He, et al., “Synthesis and in Vitro Cytotoxicity of Novel 1,4-Disubstituted Phthalazines,” Chinese Chemical Letters, Vol. 19, No. 1, 2008, pp. 29-32. doi:10.1016/j.cclet.2007.11.018

 
 
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