IJOC  Vol.2 No.2 , June 2012
Three-Component Coupling Catalyzed by Phosphine: Preparation of α-Amino γ-Oxo Acid Derivatives
ABSTRACT
The three-component coupling reaction of ethyl propiolate (1), phthalimide (2), and aldehyde (3) catalyzed by tripheny- lphosphine, was developed. A solution of an equivalent amount of 1 and 2 in benzaldehyde (3a) in the presence of 30 mol% of PPh3 was heated at 100?C for 48 h to give N-(1-ethoxycarbonyl-3-oxo-3-phenylpropyl)phthalimide (4a) in 83% yield. This reaction was thought to proceed via vinylphosphonium salt formed from the reaction of ethyl propiolate (1) with triphenylphosphine in situ.

Cite this paper
Y. Oe, T. Inoue, H. Kishimoto, M. Sasaki, T. Ohta and I. Furukawa, "Three-Component Coupling Catalyzed by Phosphine: Preparation of α-Amino γ-Oxo Acid Derivatives," International Journal of Organic Chemistry, Vol. 2 No. 2, 2012, pp. 111-116. doi: 10.4236/ijoc.2012.22017.
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