JCDSA  Vol.2 No.2 , June 2012
Dramatic Improvement of Long Lasting Post-Inflammatory Hyperpigmentation by Oral and Topical Tranexamic Acid
Abstract: Post-inflammatory hyperpigmentation is common problem, but its treatment still remains challenging. Tranexamic acid has been used to treat or prevent excessive bleeding loss in various medical conditions. There have been some reports of the effect of oral and topical tranexamic acid for treatment of pigmented disorder. Herein we report on a case of female patient who showed improvement of PIH after oral and topical tranexamic acid administration.
Cite this paper: J. Kyung Kim, S. Eun Chang, C. Hyun Won, M. Woo Lee, J. Ho Choi and K. Chan Moon, "Dramatic Improvement of Long Lasting Post-Inflammatory Hyperpigmentation by Oral and Topical Tranexamic Acid," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 2 No. 2, 2012, pp. 62-63. doi: 10.4236/jcdsa.2012.22014.

[1]   N. L. Lacz, J. Vafaie, N. I. Kihiczak and R. A. Schwartz, “Postinflammatory Hyperpigmentation: A Common but Troubling Condition,” International Journal of Dermatology, Vol. 43, No. 5, 2004, pp. 362-365. doi:10.1111/j.1365-4632.2004.02267.x

[2]   K. Maeda and M. Naganuma, “Topical trans-4-aminomethylcyclohexanecarboxylic acid prevents ultraviolet radiation induced pigmentation,” Journal of Photochemistry and Photobiology, Vol. 47, No. 2, 1998, pp. 130-141.

[3]   J. H. Lee, J. G. Park, S. H. Lim, J. Y. Kim, K. Y. Ahn, M. Y. Kim and Y. M. Park, “Localized Intradermal Microinjection of Tranexamic Acid for Treatment of Melasma in Asian Patients: A Preliminary Clinical Trial,” Dermatologic Surgery, Vol. 32, No 5, 2006, pp. 626-631. doi:10.1111/j.1524-4725.2006.32133.x

[4]   The Minister of Health, Labour and Welfare, “The Japanese Pharmacopoeia,” 14th Edition, Hirokawa Publishing, Tokyo, 2002.

[5]   K. Maeda and Y. Tomita, “Mechanism of the Inhibitory Effect of Tranexamic Acid on Melanogenesis in Cultured Human Melanocytes in the Presence of KeratinocyteConditioned Medium,” Journal of Health Science, Vol. 53, No. 4, 2007, pp. 389-396. doi:10.1248/jhs.53.389

[6]   A. Manosroi, K. Podjanasoonthon and J. Manosroi, “Development of Novel Topical Tranexamic Acid Liposome Formulations,” International Journal of Pharmaceutics, Vol. 235, No. 1, 2002, pp. 61-70. doi:10.1016/S0378-5173(01)00980-2