OJST  Vol.2 No.2 , June 2012
External apical root resorption and the release of interleukin-6 in the gingival crevucular fluid induced by a self-ligating system
ABSTRACT
The aim of this study was to investigate the amount of external apical root resorption (EARR) and the release of interleukin (IL)-6 in the gingival crevicular fluid (GCF) in subjects treated with a low-force low-friction system. Sixty patients were assigned to two groups of thirty patients for each: one group received treatment with self-ligating brackets and the other with conventional ligated edgewise brackets. All patients were treated with extraction of the maxillary first premolars. The EARR of the maxillary central incisors was evaluated on the periapical radiographs and cephalograms, taken before and after orthodontic treatment. The GCF was also collected non-invasively from the mesial and distal sides of central incisors by using filter paper strips before and after orthodontic treatment. Enzyme-linked immunosorbent assay (ELISA) kits were used to determine the IL-6 levels in the GCF samples. A significant difference was found in the amount of EARR between the patients with self-ligating brackets and conventional brackets. The mean amount of EARR was significantly lower for self-ligating brackets than conventional brackets (p < 0.05). The GCF levels of IL-6 for the patients with self-ligating brackets appliance were significantly lower than for those with the conventional brackets (p < 0.05). These results show that the mean amount of EARR and the GCF levels of IL-6 were significantly lower in the patients treated using low-force low-friction appliances than conventional brackets. Therefore, self-ligating brackets may be a useful system for reducing inflammation and EARR.

Cite this paper
Kawashima-Ichinomiya, R. , Yamaguchi, M. , Tanimoto, Y. , Asano, M. , Yamada, K. , Nakajima, R. , Fujita, S. and Kasai, K. (2012) External apical root resorption and the release of interleukin-6 in the gingival crevucular fluid induced by a self-ligating system. Open Journal of Stomatology, 2, 116-121. doi: 10.4236/ojst.2012.22021.
References
[1]   Krishnan, V. and Davidovitch, Z. (2006) Cellular, molecular, and tissue-level reactions to orthodontic force. American Journal of Orthodontics and Dentofacial Orthopedics, 129, e1-e32. doi:10.1016/j.ajodo.2005.10.007

[2]   Meikle, M.C. (2006) The tissue, cellular, and molecular regulation of orthodontic tooth movement: 100 years after Carl Sandstedt. European Journal of Orthodontics, 28, 221-240. doi:10.1093/ejo/cjl001

[3]   Alhashimi, N., Frithiof, L., Brudvik, P., et al. (2001) Orthodontic tooth movement and de novo synthesis of pro-inflammatory cytokines. American Journal of Orthodontics and Dentofacial Orthopedics, 119, 307-312. doi:10.1067/mod.2001.110809

[4]   Ba?aran, G., Ozer, T., Kaya, F.A., et al. (2006) Inter-leukins 2, 6, and 8 levels in human gingival sulcus during orthodontic treatment. American Journal of Orthodontics and Dentofacial Orthopedics, 130, e1-e6.

[5]   Hayashi, N., Yamaguchi. M., Nakajima, R., et al. (2012) T-helper 17 cells mediate the osteo/odontoclastogenesis induced by excessive orthodontic forces. Oral Diseases, in press. doi:10.1111/j.1601-0825.2011.01886.x

[6]   Yamaguchi, M., Ozawa, Y., Mishima, H., et al. (2008) Substance P increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption. American Journal of Orthodontics and Dentofacial Orthopedics, 133, 690-698. doi:10.1016/j.ajodo.2006.03.043

[7]   Damon, D.H. (1998) The Damon low-friction bracket: A biologically compatible straight-wire system. Journal of Clinical Orthodontics, 32, 670-680.

[8]   Berger, J.L. (1990) The influence of the SPEED bracket’s self-ligating design on force levels in tooth movement: A comparative in vitro study. American Journal of Orthodontics and Dentofacial Orthopedics, 97, 219-228. doi:10.1016/S0889-5406(05)80055-1

[9]   Sims, A.P., Waters, N.E., Birnie, D.J., et al. (1993) A comparison of the forces required to produce tooth movement in vitro using two self-ligating brackets and a pre-adjusted bracket employing two types of ligation. European Journal of Orthodontics, 5, 377-385.

[10]   Yamaguchi, M., Takizawa, T., Nakajima, R., et al. (2009) The damon system and release of substance p in gingival crevicular fluid during orthodontic tooth movement in adults. World Journal of Orthodontics, 10, 141-146.

[11]   Kocadereli, I., Yesil, T.N., Veske, P.S., et al. (2011) Apical root resorption: A prospective radiographic study of maxillary incisors. European Journal of Dentistry, 5, 318-323.

[12]   Brin, I. and Bollen, A.M. (2011) External apical root resorption in patients treated by serial extractions followed by mechanotherapy. American Journal of Orthodontics and Dentofacial Orthopedics, 139, e129-e134. doi:10.1016/j.ajodo.2010.08.015

[13]   Yamaguchi, M., Yoshii, M. and Kasai, K. (2006) Relationship between substance P and interleukin-1beta in gingival crevicular fluid during orthodontic tooth movement in adults. European Journal of Orthodontics, 28, 241-246. doi:10.1093/ejo/cji100

[14]   Weltman, B., Vig, K.W., Fields, H.W., Shanker, S., Kaizar, E.E., et al. (2010) Root resorption associated with ortho- dontic tooth movement: a systematic review. American Journal of Orthodontics and Dentofacial Orthopedics, 37, 462-476. doi:10.1016/j.ajodo.2009.06.021

[15]   Segal, G.R., Schiffman, P.H. and Tuncay, O.C. (2004) Meta analysis of the treatment-related factors of external apical root resorption. Orthodontics and Craniofacial Re- search, 7, 71-78. doi:10.1111/j.1601-6343.2004.00286.x

[16]   Sameshima, G.T. and Sinclair, P.M. (2004) Characteristics of patients with severe root resorption. Orthodontics and Craniofacial Research, 7, 108-114. doi:10.1111/j.1601-6343.2004.00284.x

[17]   Fox, N. (2005) Longer orthodontic treatment may result in greater external apical root resorption. Evidence-Based Dentistry, 6, 21. doi:10.1038/sj.ebd.6400304

[18]   Harris, D.A., Jones, A.S. and Darendeliler, M.A. (2006) Physical properties of root cementum: Part 8. Volumetric analysis of root resorption craters after application of controlled intrusive light and heavy orthodontic forces: A microcomputed tomography scan study. American Journal of Orthodontics and Dentofacial Orthopedics, 130, 639-647. doi:10.1016/j.ajodo.2005.01.029

[19]   Chan, E. and Darendeliler M.A. (2006) Physical properties of root cementum: Part 7. Extent of root resorption under areas of compression and tension. American Journal of Orthodontics and Dentofacial Orthopedics, 129, 504-510. doi:10.1016/j.ajodo.2004.12.018

[20]   Barbagallo, L.J., Jones, A.S., Petocz, P., et al. (2008) Physical properties of root cementum: Part 10. Comparison of the effects of invisible removable thermoplastic appliances with light and heavy orthodontic forces on premolar cementum. A microcomputed-tomography study. American Journal of Orthodontics and Dentofacial Orthopedics, 133, 218-227. doi:10.1016/j.ajodo.2006.01.043

[21]   Costopoulos, G. and Nanda, R. (1996) An evaluation of root resorption incident to orthodontic intrusion. American Journal of Orthodontics and Dentofacial Orthope- dics, 109, 543-548. doi:10.1016/S0889-5406(96)70140-3

[22]   Parker, R.J. and Harris, E.F. (1998) Directions of orthodontic tooth movements associated with external apical root resorption of the maxillary central incisor. American Journal of Orthodontics and Dentofacial Orthopedics, 114, 677-683. doi:10.1016/S0889-5406(98)70200-8

[23]   Han, G., Huang, S., Von den Hoff, J.W., et al. (2005) Root resorption after orthodontic intrusion and extrusion: An intraindividual study. Angle Orthodontist, 75, 912-918.

[24]   Weiland, F. (2003) Constant versus dissipating forces in orthodontics: The effect on initial tooth movement and root resorption. European Journal of Orthodontics, 25, 335-342. doi:10.1093/ejo/25.4.335

[25]   Brezniak, N. and Wasserstein, A. (2002) Orthodontically induced inflammatory root resorption. Part II: The clinical aspects. Angle Orthodontist, 72, 180-184.

[26]   Brezniak, N. and Wasserstein, A. (1993) Root resorption after orthodontic treatment: Part 1. Literature review. American Journal of Orthodontics and Dentofacial Orthopedics, 103, 62-66. doi:10.1016/0889-5406(93)70106-X

[27]   Pandis, N., Nasika, M., Polychronopoulou, A., et al. (2008) External apical root resorption in patients treated with conventional and self-ligating brackets. American Journal of Orthodontics and Dentofacial Orthopedics, 134, 646- 651. doi:10.1016/j.ajodo.2007.01.032

[28]   McNab, S., Battistutta, D., Taverne, A., Symons, A.L., et al. (2000) External apical root resorption following orthodontic treatment. Angle Orthodontist, 70, 227-232.

[29]   Scott, P., DiBiase, A.T., Sherriff, M., Cobourne, M.T., et al. (2008) Alignment efficiency of Damon3 self-ligating and conventional orthodontic bracket systems: A ran-domized clinical trial. American Journal of Orthodontics and Dentofacial Orthopedics, 34, e1-e8.

[30]   Chen, S.S., Greenlee, G.M., Kim, J.E., et al. (2010) Systematic review of self-ligating brackets. American Journal of Orthodontics and Dentofacial Orthopedics, 137, e1-e18. doi:10.1016/j.ajodo.2009.11.009

[31]   Damon, D.H. (1998) The rationale, evolution and clinical application of the self-ligating bracket. Clinical Orthodontics and Research, 1, 52-61.

[32]   Griffiths, H.S., Sherriff, M. and Ireland, A.J. (2005) Resistance to sliding with 3 types of elastomeric modules. American Journal of Orthodontics and Dentofacial Orthopedics, 127, 670-675. doi:10.1016/j.ajodo.2004.01.025

[33]   Kim, T.K., Kim, K.D. and Baek, S.H. (2008) Comparison of frictional forces during the initial leveling stage in various combinations of self-ligating brackets and archwires with a custom-designed typodont system. American Journal of Orthodontics and Dentofacial Orthopedics, 133, e15-e24. doi:10.1016/j.ajodo.2007.08.013

[34]   Budd, S., Daskalogiannakis, J. and Tompson, B.D. (2008) A study of the frictional characteristics of four comercially available self-ligating bracket systems. European Journal of Orthodontics, 30, 645-653. doi:10.1093/ejo/cjn058

[35]   Uematsu, S., Mogi, M. and Deguchi, T. (1996) Inter-leukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, epidermal growth factor, and beta 2-microglobulin levels are elevated in gingival crevicular fluid during human orthodontic tooth movement. Journal of Dental Research, 75, 562-567. doi:10.1177/00220345960750010801

[36]   George, A. and Evans, C.A. (2009) Detection of root resorption using dentin and bone markers. Orthodontics and Craniofacial Research, 12, 229-235. doi:10.1111/j.1601-6343.2009.01457.x

[37]   Koyama, Y., Mitsui, N., Suzuki, N., et al. (2008) Effect of compressive force on the expression of inflammatory cy- tokines and their receptors in osteoblastic Saos-2 cells. Archives of Oral Biology, 53, 488-496. doi:10.1016/j.archoralbio.2007.12.004

[38]   Lee, Y.H, Nahm, D.S, Jung, Y.K., et al. (2007) Differential gene expression of periodontal ligament cells after loading of static compressive force. Journal of Periodon- tology, 78, 446-452. doi:10.1902/jop.2007.060240

[39]   Van Gastel, J., Teughels, W., Quirynen, M., et al. (2011) Longitudinal changes in gingival crevicular fluid after placement of fixed orthodontic appliances. American Journal of Orthodontics and Dentofacial Orthopedics, 139, 735-744. doi:10.1016/j.ajodo.2009.10.043

[40]   Wright, N., Modarai, F., Cobourne, M.T., Dibiase, A.T., et al. (2011) Do you do Damon?? What is the current evidence base underlying the philosophy of this appliance system? Journal of Orthodontics, 38, 222-230. doi:10.1179/14653121141479

[41]   Pandis, N., Nasika, M., Polychronopoulou, A., Eliades, T., et al. (2008) External apical root resorption in patients treated with conventional and self-ligating brackets. American Journal of Orthodontics and Dentofacial Or- thopedics, 134, 646-651. doi:10.1016/j.ajodo.2007.01.032

[42]   Scott, P., DiBiase, A.T., Sherriff, M., Cobourne, M.T., et al. (2008) Alignment efficiency of Damon3 self-ligating and conventional orthodontic bracket systems: A ran- domized clinical trial. American Journal of Orthodontics and Dentofacial Orthopedics, 134, e1-e8. doi:10.1016/j.ajodo.2008.04.018

 
 
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